The \u27Child\u27 Remembers

Matthew 18:1-6

Can Managers Adapt to New Relationships and Roles Under NFMA?

5 pages

Can Managers Adapt to New Relationships and Roles Under NFMA?

5 pages

A Late Seventeenth-Century Reader of Sir John Suckling

Although Bodleian MS Eng. misc. c. 34 has been briefly discussed in relation to its Shakespearean extracts, this miscellany has been overlooked as a key example of seventeenth-century reader-response, particularly in relation to early modern plays and, as this article demonstrates, Suckling’s literary works. P.D.’s miscellany is a significant document not only because it offers concrete evidence (extracts, summary, and commentaries) of how Suckling was read in the seventeenth century, but also because it contextualizes this response to Suckling alongside commentary about other playwrights. These extracts from Suckling’s works show what drew readers to his work: his wit, his turns of phrase, and even his cavalier attitude. P.D.’s summary presents /Aglaura/ from the standpoint of an early modern reader and shows the depth of that reader’s engagement with the play’s byzantine intricacies. These commentaries reveal the opinions of a thoughtful reader who carefully considered Suckling’s poems, plays, and epistles. The extracts, summary, and commentaries in Bodleian MS Eng. misc. c. 34 offer one early modern approach to Suckling as a literary figure by both re-presenting selected words of the poet-playwright and preserving one reader’s response in his own words

Defining The Effect Of Environmental Perturbation On The Male Germline

Periconceptional environment, according to the Developmental Origins of Health and Disease (DOHaD) theory, influences offspring phenotype, primarily via epigenetic mechanisms. Although the paternal component in humans is poorly understood, both maternal and paternal peri-conceptional environment are now believed to contribute to this phenomenon. Manipulation of the early embryo for treating human infertility, is suspected of contributing to offspring abnormalities through epigenetic mechanisms. To directly address the effects of common assisted reproductive technology procedures on the offspring epigenome, the DNA methylation profiles of newborns conceived naturally, or through the use of intrauterine insemination (IUI), or in vitro fertilization (IVF) using Fresh or Cryopreserved (Frozen) embryo transfer, were compared. In addition to a reduction of epigenetic aberrations in the IVF conceptions using cryopreservation, metastable epialleles also exhibited altered methylation with fertility status. ART, embryo nutrition, and fertility status are thus suggested to have a lasting epigenetic effect of on the developing embryo. While the paternal contribution to the human embryo is uncertain, sperm deliver a collection of proteins and RNA to the zygote. To identify the entire cadre of intergenic spermatozoal RNAs, RNA Element (RE) discovery algorithm (REDa) was developed and applied to a spectrum of germline, embryonic, and somatic tissues. This highlighted extensive transcription throughout the human genome and yielded previously unidentified human RNAs. Human spermatogenesis was found to exhibit extensive intergenic transcription and pervasive repetitive sequence expression. By analyzing the collection of novel and annotated spermatozoal RNAs in sperm samples from the Mesalamine and Reproductive Health Study (MARS), the effect of endocrine disruptor exposure on human sperm RNA profiles was determined. Sperm RNA profiles among men and their relationship to di-butyl phthalate (DBP) was longitudinally assessed across binary (high or background) DBP crossover exposures. Numerous changes in the composition of sperm RNA elements were detected during the acute and recovery phases, which suggest that exposure to, or removal from high DBP, produces effects that require longer than one spermatogenic cycle to resolve, if at all. Overall, chronic phthalate exposure influences the male germline, and acts on the dynamic RNA expression during human spermiogenesis

The Benefits of Professional Public Land Management

13 pages (includes illustration). Contains references

Some observations on Zyryan word stress, past and present

I wish to present some comments on the position of stress in the Zyryan word in neutral surroundings, i.e. when it is unaffected by, for example, sentential stress. First thought, I shall briefly consider extant evidence of word stress placement in the past, after which I shall go on to describe some experiments to determine the extent to which stress alights on the initial syllable in Zyryan nowadays and the results. I shall also make brief mention of the possible acoustical composition of the language

The Benefits of Professional Public Land Management

13 pages (includes illustration). Contains references