8 research outputs found

    Optimizing Blue Persistent Luminescence in (Sr<sub>1−δ</sub>Ba<sub>δ</sub>)<sub>2</sub>MgSi<sub>2</sub>O<sub>7:</sub>Eu<sup>2+</sup>,Dy<sup>3+</sup> via Solid Solution for Use in Point-of-Care Diagnostics

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    Inorganic persistent luminescent phosphors are an excellent class of optical reporters for enabling sensitive point-of-care diagnostics, particularly with smartphone-based biosensing devices in testing formats such as the lateral flow assay (LFA). Here, the development of persistent phosphors for this application is focused on the solid solution (Sr<sub>1−δ</sub>Ba<sub>δ</sub>)<sub>2</sub>MgSi<sub>2</sub>O<sub>7</sub>:Eu<sup>2+</sup>,Dy<sup>3+</sup> (δ = 0, 0.125, 0.25, 0.375), which is prepared using a high-temperature solid-state reaction as confirmed by synchrotron X-ray powder diffraction. The substitution of barium for strontium enables control over the Eu<sup>2+</sup> 5d-orbital crystal field splitting (CFS) as a tool for tuning the emission wavelength while maintaining luminescence lifetimes >9 min across the composition range. Thermoluminescence measurements of the solid solution provide evidence that trap states contribute to the persistent lifetimes with the trap depths also remaining constant as a function of composition. Time-gated luminescence images of these compounds are captured on a smartphone arranged in a layout to mimic a point-of-care test and demonstrate the viability of using these materials as optical reporters. Moreover, comparing the blue-emitting (Sr<sub>0.625</sub>Ba<sub>0.375</sub>)<sub>2</sub>MgSi<sub>2</sub>O<sub>7:</sub>Eu<sup>2+</sup>,Dy<sup>3+</sup> and the green-emitting SrAl<sub>2</sub>O<sub>4</sub>:Eu<sup>2+</sup>,Dy<sup>3+</sup> in a single LFA-type format shows these two compounds can be detected and resolved simultaneously, thereby permitting the development of a multiplexed LFA

    Additional file 1: of Interventions to reduce readmissions: can complex adaptive system theory explain the heterogeneity in effectiveness? A systematic review

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    Intervention description. Characteristics of included studies of care transition interventions, as described in Penney, et al., Interventions to Reduce Readmissions: Can complex adaptive system theory explain the heterogeneity in effectiveness? A systematic review. (DOCX 45 kb

    Additional file 2: of Interventions to reduce readmissions: can complex adaptive system theory explain the heterogeneity in effectiveness? A systematic review

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    Complexity scoring. Ratings of eligible studies by complex adaptive system characteristics (CAS), interdependencies, and project success, as described in Penney, et al., Interventions to Reduce Readmissions: Can complex adaptive system theory explain the heterogeneity in effectiveness? A systematic review. (DOCX 44 kb
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