Measurement of VZ production cross sections in Z -> bb decay channels in pp collisions at 8 TeV

We present a measurement of the WZ and ZZ production cross sections in proton-proton collisions at 8 TeV in final states where one Z boson decays to b-tagged jets, while the other gauge boson, either W or Z, is detected through its leptonic decay. The results are based on data corresponding to an integrated luminosity of 18.9 /fb collected with the CMS detector at the Large Hadron Collider.Comment: LHCP 2014 Proceedin

Public Kaggle Competition "IceCube -- Neutrinos in Deep Ice"

The reconstruction of neutrino events in the IceCube experiment is crucial for many scientific analyses, including searches for cosmic neutrino sources. The Kaggle competition "IceCube -- Neutrinos in Deep ice" was a public machine learning challenge designed to encourage the development of innovative solutions to improve the accuracy and efficiency of neutrino event reconstruction. Participants worked with a dataset of simulated neutrino events and were tasked with creating a suitable model to predict the direction vector of incoming neutrinos. From January to April 2023, hundreds of teams competed for a total of $50k prize money, which was awarded to the best performing few out of the many thousand submissions. In this contribution I will present some insights into the organization of this large outreach project, and summarize some of the main findings, results and takeaways.Comment: Presented at the 38th International Cosmic Ray Conference (ICRC2023). See arXiv:2307.13047 for all IceCube contribution

A model independent parametrization of the optical properties of the refrozen IceCube drill holes

The IceCube Neutrino Observatory deployed 5160 digital optical modules (DOMs) in a cubic kilometer of deep, glacial ice below the geographic South Pole, recording the Cherenkov light of passing charged particles. While the optical properties of the undisturbed ice are nowadays well understood, the properties of the refrozen drill holes still pose a challenge. From camera observations, we expect a central, strongly scattering column shadowing a part of the DOMs' sensitive area. In MC simulation, this effect is commonly modeled as a modification to the DOMs' angular acceptance curve, reducing the forward sensitivity of the DOMs. The associated uncertainty is a dominant detector systematic for neutrino oscillation studies as well as high-energy cascade reconstructions. Over the years, several measurements and fits of the drill holes' optical properties and of the angular acceptance curve have been proposed, some of which are in tension. Here, we present a principle component analysis, which allows us to interpolate between all suggested scenarios, and thus provide a complete systematic variation within a unified framework at analysis level.Comment: Presented at the 38th International Cosmic Ray Conference (ICRC2023). See arXiv:2307.13047 for all IceCube contribution

How Many Dark Neutrino Sectors Does Cosmology Allow?

We present the very first constraints on the number of Standard Model (SM) copies with an additional Dirac right-handed neutrino. We show that solving the hierarchy problem within this framework induces in turn a severe hierarchy between the neutrino Yukawa couplings. By demanding the absence of such unnatural hierarchies, we are even able to rule out the theory

Invasive pulmonary aspergillosis complicating COVID-19 in the ICU - A case report.

It is not yet known, if critically ill COVID-19 patients are prone to fungal infections. We report a 69-year-old patient without typical risk factors for invasive pulmonary aspergillosis (IPA), who developed IPA two weeks after onset of symptoms. Our report shows that IPA may occur in critically ill COVID-19 patients

Sensitivity of the IceCube Upgrade to Atmospheric Neutrino Oscillations

IceCube DeepCore, the existing low-energy extension of the IceCube Neutrino Observatory, was designed to lower the neutrino detection energy threshold to the GeV range. A new extension, called the IceCube Upgrade, will consist of seven additional strings installed within the DeepCore fiducial volume. The new modules will have spacings of about 20 m horizontally and 3 m vertically, compared to about 40-70 m horizontally and 7 m vertically in DeepCore. It will be deployed in the polar season of 2025/26. This additional hardware features new types of optical modules with multi-PMT configurations, as well as calibration devices. This upgrade will more than triple the number of PMT channels with respect to current IceCube, and will significantly enhance its capabilities in the GeV energy range. However, the increased channel count also poses new computational challenges for the event simulation, selection, and reconstruction. In this contribution we present updated oscillation sensitivities based on the latest advancements in simulation, event selection, and reconstruction techniques.Comment: Presented at the 38th International Cosmic Ray Conference (ICRC2023). See arXiv:2307.13047 for all IceCube contribution

Towards a Cloud-native Tool for Model-based Systems Engineering of Spacecraft

The landscape of modeling tools for Model-based Systems Engineering is largely dominated by desktop applications. While these tools are highly advanced, their deployment is often challenging, especially if used by large teams. For each machine they are used on, installation and updating must be managed. Also, these applications often require considerable hardware resources. Transforming MBSE tools to use web and cloud technologies can alleviate these issues. We propose a cloud-native architecture as an example for transforming Eclipse-based tools. It is inspired by a set of requirements that have been identified by consulting several experienced domain experts. A prototype implementation shows that almost all of the must-be requirements can be fulfilled or partially fulfilled by utilizing existing cloud-native technologies. Finally, we con ducted performance measurements, which showed that the overhead of cloud technologies decrease with increasingly complex computations

IceCube -- Neutrinos in Deep Ice The Top 3 Solutions from the Public Kaggle Competition

During the public Kaggle competition "IceCube -- Neutrinos in Deep Ice", thousands of reconstruction algorithms were created and submitted, aiming to estimate the direction of neutrino events recorded by the IceCube detector. Here we describe in detail the three ultimate best, award-winning solutions. The data handling, architecture, and training process of each of these machine learning models is laid out, followed up by an in-depth comparison of the performance on the kaggle datatset. We show that on cascade events in IceCube above 10 TeV, the best kaggle solution is able to achieve an angular resolution of better than 5 degrees, and for tracks correspondingly better than 0.5 degrees. These performance measures compare favourably to the current state-of-the-art in the field

The AST/ALT (De-Ritis) ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients

The aspartat aminotransferase (AST)/alanin aminotransferase (ALT) (De-Ritis) ratio (AAR) is an easily applicable blood test. An elevated AAR on the one hand has been associated with an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD on the other hand is associated with an increase in cardiovascular disease, all-cause mortality, and diabetes. As the AAR is also elevated in case of muscular damage, we investigated AAR and its association with critical limb ischemia (CLI) in peripheral arterial occlusive disease (PAOD) patients. In our cross-sectional study, we included 1782 PAOD patients treated at our institution from 2005 to 2010. Patients with chronic alcohol consumption (>20 g/day) were excluded. AAR was calculated and the cohort was categorized into tertiles according to the AAR. An optimal cut-off value for the continuous AAR was calculated by applying a receiver operating curve analysis to discriminate between CLI and non-CLI. In our cohort, occurrence of CLI significantly increased with an elevation in AAR. As an optimal cut-off value, an AAR of 1.67 (sensitivity 34.1%, specificity 81.0%) was identified. Two groups were categorized, 1st group containing 1385 patients (AAR < 1.67) and a 2nd group with 397 patients (AAR > 1.67). CLI was more frequent in AAR > 1.67 patients (166 [41.9%]) compared to AAR < 1.67 patients (329 [23.8%]) (P < 0.001), as was prior myocardial infarction (28 [7.1%] vs 54 [3.9%], P = 0.01). Regarding inflammatory parameters, C-reactive protein (median 8.1 mg/L [2.9–28.23] vs median 4.3 mg/L [2.0–11.5]) and fibrinogen (median 427.5 mg/dL [344.25–530.0] vs 388.0 mg/dL [327.0–493.0]) also significantly differed in the 2 patient groups (both P < 0.001). Finally, an AAR > 1.67 was associated with an odds ratio (OR) of 2.0 (95% confidence interval [CI] 1.7–2.3) for CLI even after adjustment for other well-established vascular risk factors. An increased AAR is significantly associated with patients at high risk for CLI and other cardiovascular endpoints. The AAR is a broadly available and cheap marker, which might be useful to highlight patients at high risk for vascular endpoints