49 research outputs found

    Children's health and indoor air quality in primary schools and homes in Portugal-Study design

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    The main aim of the research project "On the Contribution of Schools to Children's Overall Indoor Air Exposure" is to study associations between adverse health effects, namely, allergy, asthma, and respiratory symptoms, and indoor air pollutants to which children are exposed to in primary schools and homes. Specifically, this investigation reports on the design of the study and methods used for data collection within the research project and discusses factors that need to be considered when designing such a study. Further, preliminary findings concerning descriptors of selected characteristics in schools and homes, the study population, and clinical examination are presented. The research project was designed in two phases. In the first phase, 20 public primary schools were selected and a detailed inspection and indoor air quality (IAQ) measurements including volatile organic compounds (VOC), aldehydes, particulate matter (PM2.5, PM10), carbon dioxide (CO2), carbon monoxide (CO), bacteria, fungi, temperature, and relative humidity were conducted. A questionnaire survey of 1600 children of ages 8-9 years was undertaken and a lung function test, exhaled nitric oxide (eNO), and tear film stability testing were performed. The questionnaire focused on children's health and on the environment in their school and homes. One thousand and ninety-nine questionnaires were returned. In the second phase, a subsample of 68 children was enrolled for further studies, including a walk-through inspection and checklist and an extensive set of IAQ measurements in their homes. The acquired data are relevant to assess children's environmental exposures and health status.This work was supported by Fundação para Ciência e Tecnologia through the ARIA project (PTDC/DTP-SAP/1522/2012)

    Validation of the rat model of prostate cancer: correlating seminal vesicle lesions with dorsolateral prostate lesions

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    Background/aim: Lesions in the seminal vesicle are described in the most used protocols for prostate cancer (PCa) induction. This study aimed to characterize the lesions of seminal vesicles associated with a protocol of PCa induction in rats to contribute to better characterization of this model. Materials and methods: Forty-five male Wistar Unilever rats were randomly divided into two control groups: CONT1 (n=10) and CONT2 (n=10); and two PCa-induced groups: IND1 (n=10) and IND2 (n=15), sacrificed at 35 and 61 weeks, respectively. Animals from the induced groups were exposed to a multistep protocol for PCa induction. Animals, seminal vesicles and dorsolateral prostate were weighed. Seminal vesicles and dorsolateral prostate were submitted to histopathological and immunohistochemical analysis. Results: Animals in which PCa was induced had a lower mean body weight when compared with the control animals (p<0.05). The relative mean seminal vesicle weight was higher in groups with PCa when compared with control groups (p<0.05). Although the differences were not statistically significant, animals from the IND2 group developed more lesions than animals from the IND1 and CONT2 groups. It is worth noting that the animals from group IND2 developed papillary adenomas and carcinomas in situ, which were not observed in any other group. Similar to observations in seminal vesicles, animals from group IND2 developed more dorsolateral prostate lesions than animals from the IND1 group (p<0.05). Conclusion: We observed that the longer the exposure to testosterone was, the greater was the incidence of preneoplastic and neoplastic lesions in both the seminal vesicle and the prostate, suggesting that testosterone exposure affects the spectrum of developed lesions

    Characterisation and life cycle assessment of pervious concrete with recycled concrete aggregates

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    The search for environmental preservation and conservation of natural resources gives rise to new concepts and viable technical solutions on the path to sustainable development. In this context, this study‚Äôs main objective is to analyse the influence of recycled concrete aggregates (RCAs) on the development of pervious concrete, whose use as a floor covering represents an excellent device to mitigate the urban soil sealing phenomena. For this, mechanical and hydraulic tests were carried out, in addition to microstructural analyses and the assessment of its environmental performance. The results obtained were compared to reference studies also involving the incorporation of recycled aggregates. A pilot-scale case study was conducted, involving a parking space lined with pervious concrete moulded ‚Äúin situ‚ÄĚ. In laboratory tests, permeability coefficients and mechanical strengths compatible with the literature and above the normative limit for light traffic were found. The case study demonstrated higher permeability than in the laboratory, but the flexural strength was lower, being indicated only for pedestrian traffic. The environmental assessment showed that the RCA represents a positive contribution to the environmental performance of pervious concrete. Still, attention should be given to the recycled aggregate transport distance between the concrete plant and the RCA treatment plant.The authors acknowledge the support of Funda√ß√£o de Amparo √† Pesquisa de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Cient√≠fico e Tecnol√≥gico (CNPq); Coordena√ß√£o de Aperfei√ßoamento de Pessoal de N√≠vel Superior (CAPES); Pr√≥-Reitoria de P√≥s-Gradua√ß√£o e Pesquisa da Universidade Federal de Juiz de Fora (PROPP/UFJF); Pr√≥-Reitoria de Infraestrutura da Universidade Federal de Juiz de Fora (PROINFRA/UFJF); Petra Agregados; and Associa√ß√£o Brasileira de Cimento Portland (ABCP)

    DODAB:MO versus novel liposomes for protein delivery: comparing toxicity and encapsulation efficiency

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    UID/BIA/04050/2019, funded by national funds through the FCT IP, and project FUN2CYT: Harnessing the potential for biomedical applications of pleiotropic cytokines LIF and oncostatin M (PTDC/BTM-MAT/30568/2017, POCI-01-0145-FEDER-030568) supported by POCI through FEDER and FCT IPinfo:eu-repo/semantics/publishedVersio

    Utilização de nanopartículas de TIO2 para o desenvolvimento de pavimentos rodoviários com capacidade fotocatalítica

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    A utiliza√ß√£o de nanomateriais na ind√ļstria de constru√ß√£o rodovi√°ria representa uma op√ß√£o estrategicamente inovadora que visa a modifica√ß√£o dos materiais convencionais. Neste √Ęmbito, dotar a superf√≠cie dos pavimentos rodovi√°rios de capacidade fotocatal√≠tica contribuir√° para efetuar a despolui√ß√£o do ar e a redu√ß√£o da sujidade adsorvida nestas superf√≠cies, aumentando a seguran√ßa rodovi√°ria uma vez que minimiza a presen√ßa de √≥leos e gorduras adsorvidos pelas mesmas. Neste trabalho, misturas asf√°lticas convencionais foram modificadas pela adi√ß√£o de nanopart√≠culas de TiO2 atrav√©s de dois processos diferentes: inclus√£o em volume e por aspers√£o superficial de uma solu√ß√£o aquosa de nanopart√≠culas de TiO2. As misturas asf√°lticas foram caracterizadas quimicamente e a sua morfologia e capacidade fotocatal√≠tica foram avaliadas. Os resultados obtidos demonstram que a utiliza√ß√£o de nanopart√≠culas de TiO2 (aplicadas na superf√≠cie pela t√©cnica de aspers√£o) permitiu obter misturas asf√°lticas com elevada capacidade fotocatal√≠tica, j√° que o rendimento de fotodegrada√ß√£o foi superior a 50%.FEDE

    National Food, Nutrition and Physical Activity Survey of the Portuguese general population

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    The National Food, Nutrition and Physical Activity Survey of the Portuguese general population aimed to collect nationwide and regional data on dietary intake and physical activity, and their relation with health determinants, namely socioeconomic factors. Results from this project were obtained from a representative sample of the Portuguese population, aged between three months to 84 years of age, selected from the National Heath Registry, by multistage sampling (a sample size of 5068 individuals was estimated and 5811 participants with two dietary assessments were achieved). To accomplish the EFSA requirements, a minimum, of 260 individuals in each age group (130 by sex) was planned. Two face-to-face interviews were conducted at a health care centre or participant’s home. Dietary intake was obtained by two non-consecutive days of food diaries for children (<10 years old) and two non-consecutive 24-hours recalls for the older age groups, with a time interval between 8 and 15 days, complemented with a Food Propensity Questionnaire. An electronic platform based on a client-server architecture was used to manage the field work and to assist the data collection. The Electronic Assessment Tool for 24-hours recall (eAT24) allowed the collection of dietary data by an Automated Multiple-Pass Method for 24-hours. This interview-based dietary assessment instrument allowed obtaining a very detailed description and quantification of foods, recipes, and food supplements consumed in the course of the preceding day, and it had several adaptations, described in detail in this report. The survey outcomes support solid evidence-based information covering all age groups of the population, using harmonized methodologies at the European level, and will contribute to develop a national infrastructure for monitoring progress of specific targets supporting national and European policies and future interventions on diet, physical activity and food safety.info:eu-repo/semantics/publishedVersio