Involucrar a las Generaciones Jóvenes (Generación Z y Generación Y) en los Centros Culturales.

La presente investigación se llevó a cabo en el Palacio Quintanar, un edificio renacentista del siglo XVI transformado en un dinámico centro multicultural en Segovia para abordar la falta de atractivo y compromiso de las generaciones jóvenes. Basado en mi experiencia de 15 años en la industria creativa de la pintura, este informe tiene como objetivo proporcionar un espacio en el que otros artistas puedan exhibir su talento. La cuestión principal definida por la tesis es que estos centros no son relevantes y sostenibles debido a la baja participación de las generaciones jóvenes. Para abordar esta situación, los objetivos de la investigación son implementar campañas de marketing estratégico y procesos de co-creación que inspiren la acción y que utilicen herramientas de comunicación efectivas. Desde un enfoque holístico, la investigación se centra no solo en incorporar un público joven, sino en promover la igualdad y la inclusión dentro de la comunidad cultural. La metodología de la interacción con la audiencia joven se basa en sus comportamientos y, posteriormente, se diseñará una acción específica para el Palacio Quintanar en particular. Esta elección representa la esencia del presente informe, especialmente en una ciudad como Segovia, donde la población tiende a ser mayor. Por lo tanto, el deseo, o más bien el objetivo, del estudio tiene como objetivo asegurar que los centros culturales sigan siendo relevantes y sostenibles a largo plazo, incluyendo a las generaciones más jóvenes.Máster en Comunicación con Fines Sociale

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population