New Insights into Layered Graphene Materials as Substrates to Regulate Synthesis of Ni–P Nanomaterials for Electrocatalytic Oxidation of Methanol and Water

The doping ring-core nickel phosphide/graphene nanomaterial is obtained by H2 reduction of the flower-like nickel phosphates/graphene oxide (NiPOGO) and sea urchin-like nickel phosphates/chemically converted graphene (NiPOG) substrates. The obtained structure of nickel phosphates depends on the influence of different kinds of oxygen-containing groups on the graphene substrate. The substrate can also affect the particle size and distribution of nickel phosphate nanoparticles. The substrate can adjust the particle size, distribution, and exposed growth direction of nickel phosphide. These materials with high activity are employed as electrochemical catalysts for methanol oxidation reactions, which is ∼7 times that of pure nickel phosphide, and there is a very small Tafel slope of 47 mV decade–1 in the water oxidation reaction. Our results highlight that the substrate structure is essential to catalytic materials for electrochemical oxidation of methanol and water

RESEARCH ON THE MAIN METHODS OF CORE STRENGTH TRAINING IN SPRINTERS

ABSTRACT Introduction With the development of increasingly competitive sports, coaches began experimenting with new methods for training athletes. Although among the most explored training methods is core strength training, a set of muscle groups that stabilize the trunk and hips, there are few studies on the effectiveness of this training dedicated to sprinters. Objective This paper investigates the training method of sprinters based on core strength training, studying the method and its influence on athletes’ performance. Methods Sixteen athletes with similar technical levels and physical fitness were selected, and professional coaches were invited to test the training samples. The athletes were randomly assigned to the experimental and control group (8 in each). The experimental group received core strength training for eight weeks, while the control group received general training. Results Off-core training affected the ankle joint angle of the support leg and the ankle joint angle of the swing leg (P </div

Additional file 1 of Association between obesity and short- and medium-term mortality in critically ill patients with atrial fibrillation: a retrospective cohort study

Supplementary Material

Additional file 1 of Relationship between red blood cell distribution width-to-albumin ratio and outcome of septic patients with atrial fibrillation: a retrospective cohort study

Additional file 1: Table S1. Factors related to in-hospital mortality in red blood cell distribution width-to-albumin ratio by univariate analysis

Additional file 2 of Relationship between red blood cell distribution width-to-albumin ratio and outcome of septic patients with atrial fibrillation: a retrospective cohort study

Additional file 2: Table S2. Multivariate Cox regression analyses of the association between different red blood cell distribution width-to-albumin ratio levels and in-hospital mortality after excluding patients with hepatorenal syndrome before intensive care unit admission

Data_Sheet_2_Case Report: A Novel Missense Variant in the SIPA1L3 Gene Associated With Cataracts in a Chinese Family.XLSX

The signal-induced proliferation-associated 1-like 3 (SIPA1L3) gene that encodes a putative Rap GTPase-activating protein (RapGAP) has been associated with congenital cataract and eye development abnormalities. However, our current understanding of the mutation spectrum of SIPA1L3 associated with eye defects is limited. By using whole-exome sequencing plus Sanger sequencing validation, we identified a novel heterozygous c.1871A > G (p.Lys624Arg) variation within the predicted RapGAP domain of SIPA1L3 in the proband with isolated juvenile-onset cataracts from a three-generation Chinese family. In this family, the proband's father and grandmother were also heterozygous for the c.1871A > G variation and affected by cataracts varying in morphology, severity, and age of onset. Sequence alignment shows that the Lys 624 residue of SIPA1L3 is conserved across the species. Based on the resolved structure of Rap1–Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap·GTP. We reasoned that arginine substitution of lysine 624 might have an impact on the SIPA1L3-Rap·GTP interaction, thereby affecting the regulatory function of SIPA1L3 on Rap signaling. Collectively, our finding expands the mutation spectrum of SIPA1L3 and provides new clues to the molecular mechanisms of SIPA1L3-related cataracts. Further investigations are warranted to validate the functional alteration of the p.Lys624Arg variant of SIPA1L3.</p

Enabling Reversible MnO₂/Mn²⁺ Transformation by Al³⁺ Addition for Aqueous Zn–MnO₂ Hybrid Batteries

Aqueous rechargeable Zn–manganese dioxide (Zn–MnO2) hybrid batteries based on dissolution–deposition mechanisms exhibit ultrahigh capacities and energy densities due to the two-electron transformation between MnO2/Mn2+. However, the reported Zn–MnO2 hybrid batteries usually use strongly acidic and/or alkaline electrolytes, which may lead to environmental hazards and corrosion issues of the Zn anodes. Herein, we propose a new Zn–MnO2 hybrid battery by adding Al3+ into the sulfate-based electrolyte. The hybrid battery undergoes reversible MnO2/Mn2+ transformation and exhibits good electrochemical performances, such as a high discharge capacity of 564.7 mAh g–1 with a discharge plateau of 1.65 V, an energy density of 520.8 Wh kg–1, and good cycle life without capacity decay upon 2000 cycles. Experimental results and theoretical calculation suggest that the aquo Al3+ with Brønsted weak acid nature can act as the proton-donor reservoir to maintain the electrolyte acidity near the electrode surface and prevent the formation of Zn4(OH)6(SO4)·0.5H2O during discharging. In addition, Al3+ doping during charging introduces oxygen vacancies in the oxide structure and weakens the Mn–O bond, which facilitates the dissolution reaction during discharge. The mechanistic investigation discloses the important role of Al3+ in the electrolyte, providing a new fundamental understanding of the promising aqueous Zn–MnO2 batteries

Data_Sheet_1_Case Report: A Novel Missense Variant in the SIPA1L3 Gene Associated With Cataracts in a Chinese Family.XLSX

The signal-induced proliferation-associated 1-like 3 (SIPA1L3) gene that encodes a putative Rap GTPase-activating protein (RapGAP) has been associated with congenital cataract and eye development abnormalities. However, our current understanding of the mutation spectrum of SIPA1L3 associated with eye defects is limited. By using whole-exome sequencing plus Sanger sequencing validation, we identified a novel heterozygous c.1871A > G (p.Lys624Arg) variation within the predicted RapGAP domain of SIPA1L3 in the proband with isolated juvenile-onset cataracts from a three-generation Chinese family. In this family, the proband's father and grandmother were also heterozygous for the c.1871A > G variation and affected by cataracts varying in morphology, severity, and age of onset. Sequence alignment shows that the Lys 624 residue of SIPA1L3 is conserved across the species. Based on the resolved structure of Rap1–Rap1GAP complex, homology modeling implies that the Lys 624 residue is structurally homologous to the Lys 194 of Rap1GAP, a highly conserved lysine residue that is involved in the interface between Rap1 and Rap1GAP and critical for the affinity to Rap·GTP. We reasoned that arginine substitution of lysine 624 might have an impact on the SIPA1L3-Rap·GTP interaction, thereby affecting the regulatory function of SIPA1L3 on Rap signaling. Collectively, our finding expands the mutation spectrum of SIPA1L3 and provides new clues to the molecular mechanisms of SIPA1L3-related cataracts. Further investigations are warranted to validate the functional alteration of the p.Lys624Arg variant of SIPA1L3.</p

Presentation_1_Tree-based, two-stage risk factor analysis for postoperative sepsis based on Sepsis-3 criteria in elderly patients: A retrospective cohort study.pdf

BackgroundSepsis remains the leading cause of postoperative death in elderly patients and is defined as organ dysfunction with proven or suspected infection according to Sepsis-3 criteria. To better avoid potential non-linear associations between the risk factors, we firstly used a tree-based analytic methods to explore the putative risk factors of geriatric sepsis based on the criteria in the study.MethodsData of 7,302 surgical patients aged ≥ 65 years at the Third Affiliated Hospital of Sun Yat-sen University from January 2015 to September 2020 were collected. An analytic method that combined tree-based analysis with the method of Mantel-Haenszel and logistic regression was adopted to assess the association between 17 putative risk factors and postoperative sepsis defined by the Sepsis-3 guideline by controlling 16 potential confounding factors.ResultsAmong the 16 potential covariates, six major confounders were statistically identified by the tree-based model, including cerebrovascular diseases, preoperative infusion of red blood cells, pneumonia, age ≥ 75, malignant tumor and diabetes. Our analysis indicated that emergency surgery increases the risk of postoperative sepsis in elderly patients by more than six times. The type of surgery is also a crucial risk factor for sepsis, particularly transplantation and neurosurgery. Other risk factors were duration of surgery > 120 min, administration of steroids, hypoalbuminemia, elevated creatinine, blood urea nitrogen, hematocrit, platelets, glucose, white blood cell count, abnormal neutrophil-to-lymphocyte ratio and elevated hsCRP-to-albumin ratio.ConclusionsOur study uses an effective method to explore some risk factors for postoperative sepsis in elderly by adjusting many potential confounders and it can provide information for intervention design.</p

Cumulative effect analyses of rs3737884 and rs16850797 in <i>ADIPOR1</i> associated with risk of T2D, CAD and T2D with CAD.

<p>Risk alleles are rs3737884, G and rs16850797, C, respectively. CAD, coronary artery disease; T2D, type 2 diabetes; T2D+CAD, T2D with CAD; OR, odds ratios; CI, confidence interval. OR values are calculated using those carrying one or no risk alleles as the reference group. OR and <i>P</i> values are obtained by Pearson’s χ²; <i>P</i>_trend, <i>P</i>-value for trend is obtained by performing a χ² test for linear trend in EpiInfo version 6; All OR, <i>P</i> and <i>P</i>_trend values are unadjusted for gender, age and body mass index; Statistical significances are considered as <i>P</i>≤0.05. ^aNumbers of patients with T2D vary because of missing genotype data.</p