2 research outputs found
Relative Frequency Histograms of Distances from Human CNVs to the Nearest Centromere or Telomere
<p>Relative frequency histograms (striped blue bars) are compared to their expected distributions if CNVs were distributed randomly within the genome (grey bars); these expected distributions are fitted to Gaussian distributions (grey lines). Red lines represent 99.9999% prediction confidence intervals from the fitted curves.</p
Relative Frequencies of the Ratio of <i>K<sub>A</sub></i> to <i>K<sub>S</sub></i> for Human–Mouse 1:1 Orthologous Genes
<div><p>(A) <i>K<sub>A</sub>/K<sub>S</sub></i> ratios for all human–mouse orthologue pairs (median <i>K<sub>A</sub>/K<sub>S</sub> =</i> 0.094).</p><p>(B) <i>K<sub>A</sub>/K<sub>S</sub></i> ratios for orthologue pairs of human genes that are completely encompassed in human CNVs (median <i>K<sub>A</sub>/K<sub>S</sub> =</i> 0.112).</p><p>(C) <i>K<sub>A</sub>/K<sub>S</sub></i> ratios for orthologue pairs of mouse genes completely encompassed in mouse CNVs (median <i>K<sub>A</sub>/K<sub>S</sub> =</i> 0.081). A Kolmogorov-Smirnov test between (A) and (B) demonstrates that <i>K<sub>A</sub>/K<sub>S</sub></i> values are significantly higher, on average, for human genes completely encompassed in human CNVs than for all human–mouse orthologue pairs (<i>p</i> = 1.7 Ă— 10<sup>−2</sup>). On the other hand, genes completely encompassed in mouse CNVs exhibit significantly lower <i>K<sub>A</sub>/K<sub>S</sub></i> values than all human–mouse orthologue pairs (<i>p</i> = 3.3 Ă— 10<sup>−3</sup>).</p></div