Implementing the multimodel generalized beta estimator in stata and its application

The multimodel generalized beta estimator (MGBE) described by von Hippel, Scarpino and Hola (2014) provides researchers with an improved way to estimate inequality from binned incomes. To extend the application of MGBE, the mgbe command is developed in Stata. In this report, the implementation and performance of mgbe are discussed.Statistic

A One Health overview, facilitating advances in comparative medicine and translational research.

Table of contentsA1 One health advances and successes in comparative medicine and translational researchCheryl StroudA2 Dendritic cell-targeted gorilla adenoviral vector for cancer vaccination for canine melanomaIgor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. CurielA3 Viroimmunotherapy for malignant melanoma in the companion dog modelJeffrey N. Bryan, David Curiel, Igor Dmitriev, Elena Kashentseva, Hans Rindt, Carol Reinero, Carolyn J. HenryA4 Of mice and men (and dogs!): development of a commercially licensed xenogeneic DNA vaccine for companion animals with malignant melanomaPhilip J. BergmanA5 Successful immunotherapy with a recombinant HER2-expressing Listeria monocytogenes in dogs with spontaneous osteosarcoma paves the way for advances in pediatric osteosarcomaNicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha, Margie Huebner, Yvonne PatersonA6 Human clinical development of ADXS-HER2Daniel O'ConnorA7 Leveraging use of data for both human and veterinary benefitLaura S. TremlA8 Biologic replacement of the knee: innovations and early clinical resultsJames P. StannardA9 Mizzou BioJoint Center: a translational success storyJames L. CookA10 University and industry translational partnership: from the lab to commercializationMarc JacobsA11 Beyond docking: an evolutionarily guided OneHealth approach to drug discoveryGerald J. Wyckoff, Lee Likins, Ubadah Sabbagh, Andrew SkaffA12 Challenges and opportunities for data applications in animal health: from precision medicine to precision husbandryAmado S. GuloyA13 A cloud-based programmable platform for healthHarlen D. HaysA14 Comparative oncology: One Health in actionAmy K. LeBlancA15 Companion animal diseases bridge the translational gap for human neurodegenerative diseaseJoan R. Coates, Martin L. Katz, Leslie A. Lyons, Gayle C. Johnson, Gary S. Johnson, Dennis P. O'BrienA16 Duchenne muscular dystrophy gene therapyDongsheng DuanA17 Polycystic kidney disease: cellular mechanisms to emerging therapiesJames P. CalvetA18 The domestic cat as a large animal model for polycystic kidney diseaseLeslie A. Lyons, Barbara GandolfiA19 The support of basic and clinical research by the Polycystic Kidney Disease FoundationDavid A. BaronA20 Using naturally occurring large animal models of human disease to enable clinical translation: treatment of arthritis using autologous stromal vascular fraction in dogsMark L. WeissA21 Regulatory requirements regarding clinical use of human cells, tissues, and tissue-based productsDebra A. WebsterA22 Regenerative medicine approaches to Type 1 diabetes treatmentFrancis N. KaranuA23 The zoobiquity of canine diabetes mellitus, man's best friend is a friend indeed-islet transplantationEdward J. RobbA24 One Medicine: a development model for cellular therapy of diabetesRobert J. Harman

Boston University Concert Choir: "An Evening of American Song," March 1, 1992

This is the concert program of the Boston University Concert Choir performance on Sunday, March 1, 1992 at 7:30 p.m., at the Concert Hall, 855 Commonwealth Avenue. Works performed were Memories: A) Very Pleasant; B) Rather Sad by Charles Ives, Green Finch and Linnet Bird by Stephen Sondheim, Lullaby by Giancarlo Menotti, The Daisies by Samuel Barber, Rain Has Fallen by S. Barber, The Bird by Jon Duke, "Candide's Lament" from "Candide" by Leonard Bernstein, Sweet Suffolk Owl by Richard Hundley, "Laurie's Song" from "The Tender Land" by Aaron Copland, "Plum Pudding" from "Four Recipes" by L. Bernstein, Sam Was a Man by Vincent Persichetti, Sure on This Shining Night by S. Barber, Glory to God n the Highest by Randall Thompson, The Lobster Quadrille, The Lullaby of the Duchess, and Father William fron "Alice in Wonderland" by Irving Fine, The Road Note Taken and Choose Something Like a Star from "Frostiana" by R. Thompson, and Circus BAnd by C. Ives. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund

Duan Lolat culture during the times capital city of Jakarta

The capital city of Jakarta is one of the places that most people in Indonesia want to visit, including people from West Southeast Maluku ethnicity, Maluku Province. Not a few migrants from West Southeast Maluku who live in Jakarta when returning to their hometowns invite their relatives to try their luck in the capital city of Jakarta. They come to settle down while still preserving the customs and culture of the people of West Southeast Maluku better known as the Tanimbar Islands. The purpose of this paper is to reveal the duan lolat culture that is still preserved by migrant communities from the Tanimbar islands even though they have migrated to the capital city of Jakarta and its surroundings. One of them is the value of kinship called Duan Lolat. The research was conducted using the historical method. The sources used were written sources such as literature studies, documents, and interviews with traditional leaders and Tanimbar people in Jakarta. The results of this study show that Duan and Lolat are social statuses derived from marital relationships, and marriage is the basis for determining the social status of Duan and Lolat. In marriage, the party who gives the daughter will in turn become Duan, while the party who receives the daughter will become Lolat. After marriage, the female family becomes Duan while the male family, the offspring of the married couple, becomes Lolat from the female family. The institutionalization of the Duan Lolat value occurs throughout human life, starting from birth, marriage, house construction, to death

Modeling and simulation of fructo-oligosaccharides production

It is foreseen that Systems Biology will have a great impact not only in Metabolic Engineering and Drug Discovery efforts, but also in Bioprocess development and optimization. In fact, the computational tools developed in this area made possible to simulate a biochemical process with a mathematical model comprising dynamical equations based on first principles as well as empirical kinetic equations and parameters that can be estimated from experimental data. Fructo-oligosaccharides (FOS) have become important as healthy food ingredients because of their beneficial characteristics to the health of human (Lee, 1999). They can be obtained biotechnologically using the enzyme Betafructofuranosidase, produced by some fungi. The main purpose of this work was to develop a mathematical model able to simulate the formation of FOS in a bioreactor, in order to perform a faster optimization of the FOS production process, allowing to identify which parameters can influence the final amount of FOS. An empirical model presented by Kow Jen Duan et al (1994) was used to obtain the first set of reactions. Several hydrolysis equations were added in order to achieve a general mathematical model of the occurring enzymatic reactions. After the reformulation of the Kow Jen Duan model, the kinetic parameters were determined from experimental data using the System Biology toolbox [2] with the Simulated Annealing method for curve fitting. Several experiments in bioreactors were performed with two different FOS producing fungi for that purpose. The time evolution of 7 state variables (Sucrose, Glucose, Fructose, 1-Kestose, Nystose, 1-Fructosyl Nystose and Biomass) was considered. After parameter fitting, several simulations were performed in MatLab and the simulation results were compared with experimental data, exhibiting a very satisfactory correlation for both fungal cultures. Correlation coefficients of 0.9980 - 0.9549 between simulated and experimental data were obtained. This model will be used to optimize the production process, using an optimization tool that has been developed in our research group

Emotional Attachment and Its Limits: Mengzi, Gaozi and the Guodian Discussions

Mengzi maintained that both benevolence (ren 仁) and rightness (yi 義) are naturally-given in human nature. This view has occupied a dominant place in Confucian intellectual history. In Mencius 6A, Mengzi's interlocutor, Gaozi, contests this view, arguing that rightness is determined by (doing what is fitting, in line with) external circumstances. I discuss here some passages from the excavated Guodian texts, which lend weight to Gaozi's view. The texts reveal nuanced considerations of relational proximity and its limits, setting up requirements for moral action in scenarios where relational ties do not play a motivational role. I set out yi's complexity in these discussions, highlighting its implications for (i) the nei-wai debate; (ii) the notion of yi as "rightness," or doing the right thing; and (iii) how we can understand the connection between virtue and right action in these early Confucian debates. This material from the excavated texts not only provides new perspectives on a longstanding investigation of human nature and morality, it also challenges prevailing views on Warring States Confucian intellectual history. In the well-known debate between Mengzi and Gaozi in Mencius 6A, Mengzi maintained that both ren and yi are naturally-given 1 in human nature. The figure 1 To say that ren and yi are naturally-given is not to say that they are fully-developed from the start. I use the phrase "naturally-given" throughout the paper to indicate where a particular capacity or resource (ren or yi) may be found, rather than its final polished state

Baroque Chamber Music Concert, April 30, 1992

This is the concert program of the Baroque Chamber Music Concert on Thursday, April 30, 1992 at 8:30 p.m., at the Marshall Room, 855 Commonwealth Avenue. Works performed were QUartet in G minor by Georg Phillipp Telemann, Trio Sonata in D minor by George Frideric Handel, Cantata, "Ich Suchte des Nachts" by Dietrich Buxtehude, If Music Be The Food of Love by Henry Purcell, Lamento d'Arianna by Claudio Monteverdi, O come sei gentile by C. Monteverdi, and Quartet in G major by G. P. Telemann. Digitization for Boston University Concert Programs was supported by the Boston University Humanities Library Endowed Fund