Depolarized Holography with Polarization-multiplexing Metasurface

The evolution of computer-generated holography (CGH) algorithms has prompted significant improvements in the performances of holographic displays. Nonetheless, they start to encounter a limited degree of freedom in CGH optimization and physical constraints stemming from the coherent nature of holograms. To surpass the physical limitations, we consider polarization as a new degree of freedom by utilizing a novel optical platform called metasurface. Polarization-multiplexing metasurfaces enable incoherent-like behavior in holographic displays due to the mutual incoherence of orthogonal polarization states. We leverage this unique characteristic of a metasurface by integrating it into a holographic display and exploiting polarization diversity to bring an additional degree of freedom for CGH algorithms. To minimize the speckle noise while maximizing the image quality, we devise a fully differentiable optimization pipeline by taking into account the metasurface proxy model, thereby jointly optimizing spatial light modulator phase patterns and geometric parameters of metasurface nanostructures. We evaluate the metasurface-enabled depolarized holography through simulations and experiments, demonstrating its ability to reduce speckle noise and enhance image quality

Actuation-Augmented Biohybrid Robot by Hyaluronic Acid-Modified Au Nanoparticles in Muscle Bundles to Evaluate Drug Effects

Biohybrid robots, which comprise soft materials with biological components, have the potential to sense, respond, and adapt to changing environmental loads dynamically. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. In the actuation part, however, since a muscle cell-based biohybrid robot is limited in that the driving force is weak, it is difficult to evaluate drug and toxicological effects by distinguishing changes in the biohybrid robot’s motion. To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles. The motion of the fabricated biohybrid robot was improved due to the enhanced differentiation and the improved electrical conductivity of muscle bundles by HA-AuNPs. In addition, the fabricated biohybrid robot exhibited huge changes in motion with respect to the addition of positive and negative inotropic drugs. The proposed biohybrid robot has the potential for neuromuscular disease drug screening by incorporating nervous tissues such as motor neuron organoids and brain organoids

Actuation-Augmented Biohybrid Robot by Hyaluronic Acid-Modified Au Nanoparticles in Muscle Bundles to Evaluate Drug Effects

Biohybrid robots, which comprise soft materials with biological components, have the potential to sense, respond, and adapt to changing environmental loads dynamically. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. In the actuation part, however, since a muscle cell-based biohybrid robot is limited in that the driving force is weak, it is difficult to evaluate drug and toxicological effects by distinguishing changes in the biohybrid robot’s motion. To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles. The motion of the fabricated biohybrid robot was improved due to the enhanced differentiation and the improved electrical conductivity of muscle bundles by HA-AuNPs. In addition, the fabricated biohybrid robot exhibited huge changes in motion with respect to the addition of positive and negative inotropic drugs. The proposed biohybrid robot has the potential for neuromuscular disease drug screening by incorporating nervous tissues such as motor neuron organoids and brain organoids

Actuation-Augmented Biohybrid Robot by Hyaluronic Acid-Modified Au Nanoparticles in Muscle Bundles to Evaluate Drug Effects

Biohybrid robots, which comprise soft materials with biological components, have the potential to sense, respond, and adapt to changing environmental loads dynamically. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. In the actuation part, however, since a muscle cell-based biohybrid robot is limited in that the driving force is weak, it is difficult to evaluate drug and toxicological effects by distinguishing changes in the biohybrid robot’s motion. To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles. The motion of the fabricated biohybrid robot was improved due to the enhanced differentiation and the improved electrical conductivity of muscle bundles by HA-AuNPs. In addition, the fabricated biohybrid robot exhibited huge changes in motion with respect to the addition of positive and negative inotropic drugs. The proposed biohybrid robot has the potential for neuromuscular disease drug screening by incorporating nervous tissues such as motor neuron organoids and brain organoids

Actuation-Augmented Biohybrid Robot by Hyaluronic Acid-Modified Au Nanoparticles in Muscle Bundles to Evaluate Drug Effects

Biohybrid robots, which comprise soft materials with biological components, have the potential to sense, respond, and adapt to changing environmental loads dynamically. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. In the actuation part, however, since a muscle cell-based biohybrid robot is limited in that the driving force is weak, it is difficult to evaluate drug and toxicological effects by distinguishing changes in the biohybrid robot’s motion. To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles. The motion of the fabricated biohybrid robot was improved due to the enhanced differentiation and the improved electrical conductivity of muscle bundles by HA-AuNPs. In addition, the fabricated biohybrid robot exhibited huge changes in motion with respect to the addition of positive and negative inotropic drugs. The proposed biohybrid robot has the potential for neuromuscular disease drug screening by incorporating nervous tissues such as motor neuron organoids and brain organoids

Actuation-Augmented Biohybrid Robot by Hyaluronic Acid-Modified Au Nanoparticles in Muscle Bundles to Evaluate Drug Effects

Biohybrid robots, which comprise soft materials with biological components, have the potential to sense, respond, and adapt to changing environmental loads dynamically. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. In the actuation part, however, since a muscle cell-based biohybrid robot is limited in that the driving force is weak, it is difficult to evaluate drug and toxicological effects by distinguishing changes in the biohybrid robot’s motion. To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles. The motion of the fabricated biohybrid robot was improved due to the enhanced differentiation and the improved electrical conductivity of muscle bundles by HA-AuNPs. In addition, the fabricated biohybrid robot exhibited huge changes in motion with respect to the addition of positive and negative inotropic drugs. The proposed biohybrid robot has the potential for neuromuscular disease drug screening by incorporating nervous tissues such as motor neuron organoids and brain organoids

Actuation-Augmented Biohybrid Robot by Hyaluronic Acid-Modified Au Nanoparticles in Muscle Bundles to Evaluate Drug Effects

Biohybrid robots, which comprise soft materials with biological components, have the potential to sense, respond, and adapt to changing environmental loads dynamically. Instead of humans and other living things, biohybrid robots can be used in various fields such as drug screening and toxicity assessment. In the actuation part, however, since a muscle cell-based biohybrid robot is limited in that the driving force is weak, it is difficult to evaluate drug and toxicological effects by distinguishing changes in the biohybrid robot’s motion. To overcome this limitation, we introduced hyaluronic acid-modified gold nanoparticles (HA-AuNPs) into a muscle bundle-based biohybrid robot that moves forward in response to electrical stimulation. To enhance the actuation of muscle bundles, HA-AuNPs were embedded into the muscle bundles. The motion of the fabricated biohybrid robot was improved due to the enhanced differentiation and the improved electrical conductivity of muscle bundles by HA-AuNPs. In addition, the fabricated biohybrid robot exhibited huge changes in motion with respect to the addition of positive and negative inotropic drugs. The proposed biohybrid robot has the potential for neuromuscular disease drug screening by incorporating nervous tissues such as motor neuron organoids and brain organoids

High-contrast, speckle-free, true 3D holography via binary CGH optimization

Holography is a promising approach to implement the three-dimensional (3D) projection beyond the present two-dimensional technology. True 3D holography requires abilities of arbitrary 3D volume projection with high-axial resolution and independent control of all 3D voxels. However, it has been challenging to implement the true 3D holography with high-reconstruction quality due to the speckle. Here, we propose the practical solution to realize speckle-free, high-contrast, true 3D holography by combining random-phase, temporal multiplexing, binary holography, and binary optimization. We adopt the random phase for the true 3D implementation to achieve the maximum axial resolution with fully independent control of the 3D voxels. We develop the high-performance binary hologram optimization framework to minimize the binary quantization noise, which provides accurate and high-contrast reconstructions for 2D as well as 3D cases. Utilizing the fast operation of binary modulation, the full-color high-framerate holographic video projection is realized while the speckle noise of random phase is overcome by temporal multiplexing. Our high-quality true 3D holography is experimentally verified by projecting multiple arbitrary dense images simultaneously. The proposed method can be adopted in various applications of holography, where we show additional demonstration that realistic true 3D hologram in VR and AR near-eye displays. The realization will open a new path towards the next generation of holography

High-Performance Protonic Ceramic Electrochemical Cells

Protonic ceramic electrochemical cells (PCECs) have attracted considerable attention owing to their ability to reversibly convert chemical fuels into electricity at low temperatures below 600 °C. However, extreme sintering conditions during conventional convection-based heating induce critical problems for PCECs such as nonstoichiometric electrolytes and microstructural coarsening of the electrodes, leading to performance deterioration. Therefore, we fabricated PCECs via a microwave-assisted sintering process (MW-PCEC). Owing to the ultrafast ramping rate (∼50 °C/min) with bipolar rotation and the resistive heating nature of microwave-assisted sintering, undesirable cation diffusion and grain growth were effectively suppressed, thus producing PCECs with stoichiometric electrolytes and nanostructured fuel electrodes. The MW-PCEC achieved electrochemical performance in both in fuel cell (0.85 W cm–2) and in electrolysis cell (1.88 A cm–2) modes at 600 °C (70% and 254% higher than the conventionally sintered PCEC, respectively) demonstrating the effectiveness of using an ultrafast sintering technique to fabricate high-performance PCECs