The relationship between visceral adiposity index and blood pressure levels in females.

<p>The relationship between visceral adiposity index and blood pressure levels in females.</p

The relationship between visceral adiposity index and blood pressure levels in males.

The relationship between visceral adiposity index and blood pressure levels in males.</p

The basic characteristics of the female participants.

<p>The basic characteristics of the female participants.</p

The basic characteristics of the male participants.

<p>The basic characteristics of the male participants.</p

Expression profiles of circulating miR-122, -140-3p, -720, -2861, and -3149 in swine AMI model.

<p>The myocardium unstained by Evans blue dye represented ischemic myocardium, and the triphenyltetrazolium chloride (TTC)-unstained white myocardium was identified as infarct zone, indicating the success of AMI model (A). Compared with the sham group, miR-122 plasma levels were up-regulated after 180 and 240 min of coronary occlusion (B), and miR-3149 plasma levels were elevated from 30 min to 240 min after myocardial ischemia (F). No significant differences of plasma levels of cTnI were detected within 240 min of myocardial infarction versus the sham group (G). Abbreviations: AMI-NVF = AMI without ventricular fibrillation, AMI-VF = AMI with ventricular fibrillation, ISCH = ischemia.</p

miRNA expression profile and classification performance for ACS versus non-ACS in the training data set including 394 ACS and 145 non-ACS patients.

<p>Abbreviations: AUC = area under the receiver operating characteristic curve; CI = confidence interval.</p><p>miRNA expression profile and classification performance for ACS versus non-ACS in the training data set including 394 ACS and 145 non-ACS patients.</p

Expression profiles of candidate miRNAs in non-CHD, SA, UA, and AMI patients in a cohort of human samples.

<p>The 7 candidate miRNAs were first evaluated with qRT-PCR using 111 samples including 21 non-CHD, 30 SA, 30 UA, and 30 AMI patients. miR-122 and -720 were significantly up-regulated in the AMI group compared with the non-CHD group (A and D), and miR-122, -140-3p, -144, -720, -2861, and -3149 were increased in the acute coronary syndrome (ACS, UA + AMI) group compared with the non-ACS (non-CHD + SA) group (A, B, C, D, F, and G). Abbreviations: CHD = coronary heart disease, SA = stable angina, UA = unstable angina, AMI = acute myocardial infarction.</p

Expression profiles of plasma miR-122, -140-3p, -720, -2861, and -3149 in ACS and non-ACS patients in the training data set.

<p>A total of 539 plasma samples were used for the training data set in deriving the miRNA panel for use in the classification of ACS and non-ACS. The expression levels of miR-122, -140-3p, -720, -2861, and -3149 were dramatically elevated in the ACS (UA + AMI) group compared with the non-ACS (non-CHD + SA) group (A to E). The determination values of these five plasma miRNAs were analyzed by ROC curves (F). Abbreviations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125430#pone.0125430.g001" target="_blank">Fig 1</a>.</p

Expression profiles of miR-122, -140-3p, -720, -2861, and -3149 in non-CHD, SA, UA, and AMI patients in another cohort of human samples.

<p>The expression profiles of miR-122, -140-3p, -720, -2861, and -3149 were further tested in 428 additional plasma samples, including 51 non-CHD, 43 SA, 257 UA, and 77 AMI patients with qRT-PCR. The results showed that plasma miR-122, -140-3p, -720, -2861, and -3149 were significantly up-regulated in the acute coronary syndrome (ACS, UA + AMI) group versus the non-ACS (non-CHD + SA) group (A to E); and miR-2861 and -3149 were up-regulated in the AMI group versus the non-CHD and SA groups (D and E). Abbreviations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0125430#pone.0125430.g001" target="_blank">Fig 1</a>.</p

–log₁₀<i>P</i> values for the associations of 39 SNPs in <i>SGK1</i>, <i>SGK2</i> and <i>SGK3</i> with blood pressure responses to low-sodium intervention (a) and high-sodium intervention (b).

<p>Labeled SNP was significant after Bonferroni correction. The horizontal dashed lines indicate the Bonferroni corrected significant level.</p