Revisiting On-Line Discussion as Practice for Reflective Thinking in Three Sequential Classes

In a previous study, the authors questioned the potential of an on-line environment for increasing productive reflection in three sequential education classes. Of their findings, the issue of consistency stood out as particularly perplexing, namely, why did students exhibit high level reflections sometimes, but not all the time, in an on-line environment? In this follow-up study, the authors question whether in-class reflections coupled with on-line prompts could yield consistently high level pre-service teacher reflections, as measured by individual and class progress over time. This study also examines perceived relationships between the length of a student\u27s reflection and its productivity, as well as a student\u27s depth of focus and productivity. Using the same scoring approach as our previous study, our discussion of the results examines the usefulness of on-line environments for promoting consistently high level pre-service teacher reflection

Using Technology to Develop Preservice Teachers\u27 Reflective Thinking

Developing high-level reflection skills proves troublesome for some preservice teachers. To examine the potential of an online environment for increasing productive reflection, students in three sequential undergraduate education classes responded to regular online prompts. We coded student comments for productive and unproductive reflection, knowledge integration, and analysis of the four aspects of teaching (learners and learning, subject matter knowledge, assessment and instruction ) as described by Davis, Bain, & Harrington (2001). We adapted a scoring approach recommended by Davis & Linn, (2000); Davis (2003) to analyze what aspects of teaching preservice teachers included, emphasized, and integrated when they reflected on their own beliefs about teaching. Discussion examines the utility of online environments for producing productive preservice teacher reflection

Stirring up trouble: Multi-scale mixing measures for steady scalar sources

The mixing efficiency of a flow advecting a passive scalar sustained by steady sources and sinks is naturally defined in terms of the suppression of bulk scalar variance in the presence of stirring, relative to the variance in the absence of stirring. These variances can be weighted at various spatial scales, leading to a family of multi-scale mixing measures and efficiencies. We derive a priori estimates on these efficiencies from the advection--diffusion partial differential equation, focusing on a broad class of statistically homogeneous and isotropic incompressible flows. The analysis produces bounds on the mixing efficiencies in terms of the Peclet number, a measure the strength of the stirring relative to molecular diffusion. We show by example that the estimates are sharp for particular source, sink and flow combinations. In general the high-Peclet number behavior of the bounds (scaling exponents as well as prefactors) depends on the structure and smoothness properties of, and length scales in, the scalar source and sink distribution. The fundamental model of the stirring of a monochromatic source/sink combination by the random sine flow is investigated in detail via direct numerical simulation and analysis. The large-scale mixing efficiency follows the upper bound scaling (within a logarithm) at high Peclet number but the intermediate and small-scale efficiencies are qualitatively less than optimal. The Peclet number scaling exponents of the efficiencies observed in the simulations are deduced theoretically from the asymptotic solution of an internal layer problem arising in a quasi-static model.Comment: 37 pages, 7 figures. Latex with RevTeX4. Corrigendum to published version added as appendix

The Physics of the B Factories

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C

An Extensive Evaluation of the Internet's Open Proxies

Open proxies forward traffic on behalf of any Internet user. Listed on open proxy aggregator sites, they are often used to bypass geographic region restrictions or circumvent censorship. Open proxies sometimes also provide a weak form of anonymity by concealing the requestor's IP address. To better understand their behavior and performance, we conducted a comprehensive study of open proxies, encompassing more than 107,000 listed open proxies and 13M proxy requests over a 50 day period. While previous studies have focused on malicious open proxies' manipulation of HTML content to insert/modify ads, we provide a more broad study that examines the availability, success rates, diversity, and also (mis)behavior of proxies. Our results show that listed open proxies suffer poor availability--more than 92% of open proxies that appear on aggregator sites are unresponsive to proxy requests. Much more troubling, we find numerous examples of malicious open proxies in which HTML content is manipulated to mine cryptocurrency (that is, cryptojacking). We additionally detect TLS man-in-the-middle (MitM) attacks, and discover numerous instances in which binaries fetched through proxies were modified to include remote access trojans and other forms of malware. As a point of comparison, we conduct and discuss a similar measurement study of the behavior of Tor exit relays. We find no instances in which Tor relays performed TLS MitM or manipulated content, suggesting that Tor offers a far more reliable and safe form of proxied communication

Adjuvant nab-Paclitaxel + Gemcitabine in Resected Pancreatic Ductal Adenocarcinoma: Results From a Randomized, Open-Label, Phase III Trial

PURPOSE: This randomized, open -label trial compared the efficacy and safety of adjuvant nabpaclitaxel + gemcitabine with those of gemcitabine for resected pancreatic ductal adenocarcinoma (ClinicalTrials.gov identifier: NCT01964430). METHODS: We assigned 866 treatment -naive patients with pancreatic ductal adenocarcinoma to nab-paclitaxel (125 mg/m2) + gemcitabine (1,000 mg/m(2)) or gemcitabine alone to one 30-40 infusion on days 1, 8, and 15 of six 28 -day cycles. The primary end point was independently assessed disease -free survival (DFS). Additional end points included investigator-assessed DFS, overall survival (OS), and safety. RESULTS: Two hundred eighty-seven of 432 patients and 310 of 434 patients completed nabpaclitaxel + gemcitabine and gemcitabine treatment, respectively. At primary data cutoff (December 31, 2018; median follow-up, 38.5 [interquartile range [IQR], 33.8-43 months), the median independently assessed DFS was 19.4 (nab-paclitaxel + gemcitabine) versus 18.8 months (gemcitabine; hazard ratio [HR], 0.88; 95% CI, 0.729 to 1.063; P =.18). The median investigator-assessed DFS was 16.6 (IQR, 8.4-47.0) and 13.7 (IQR, 8.3-44.1) months, respectively (HR, 0.82; 95% CI, 0.694 to 0.965; P=.02). The median OS (427 events; 68% mature) was 40.5 (IQR, 20.7 to not reached) and 36.2 (IQR, 17.7-53.3) months, respectively (HR, 0.82; 95% CI, 0.680 to 0.996; P =.045). At a 16 -month follow-up (cutoff, April 3, 2020; median follow-up, 51.4 months [IQR, 47.0-57.0]), the median OS (511 events; 81% mature) was 41.8 (nab-paclitaxel + gemcitabine) versus 37.7 months (gemcitabine; HR, 0.82; 95% CI, 0.687 to 0.973; P =.0232). At the 5 -year follow-up (cutoff, April 9, 2021; median follow-up, 63.2 months [IQR, 60.1-68.7]), the median OS (555 events; 88% mature) was 41.8 versus 37.7 months, respectively (HR, 0.80; 95% CI, 0.678 to 0.947; P =.0091). Eighty-six percent (nab-paclitaxel + gemcitabine) and 68% (gemcitabine) of patients experienced grade >= 3 treatment -emergent adverse events. Two patients per study arm died of treatment -emergent adverse events. CONCLUSION: The primary end point (independently assessed DFS) was not met despite favorable OS seen with nab-paclitaxel + gemcitabine

Gene Expression Profiles of Human Dendritic Cells Interacting with Aspergillus fumigatus in a Bilayer Model of the Alveolar Epithelium/Endothelium Interface

The initial stages of the interaction between the host and Aspergillus fumigatus at the alveolar surface of the human lung are critical in the establishment of aspergillosis. Using an in vitro bilayer model of the alveolus, including both the epithelium (human lung adenocarcinoma epithelial cell line, A549) and endothelium (human pulmonary artery epithelial cells, HPAEC) on transwell membranes, it was possible to closely replicate the in vivo conditions. Two distinct sub-groups of dendritic cells (DC), monocyte-derived DC (moDC) and myeloid DC (mDC), were included in the model to examine immune responses to fungal infection at the alveolar surface. RNA in high quantity and quality was extracted from the cell layers on the transwell membrane to allow gene expression analysis using tailored custom-made microarrays, containing probes for 117 immune-relevant genes. This microarray data indicated minimal induction of immune gene expression in A549 alveolar epithelial cells in response to germ tubes of A. fumigatus. In contrast, the addition of DC to the system greatly increased the number of differentially expressed immune genes. moDC exhibited increased expression of genes including CLEC7A, CD209 and CCL18 in the absence of A. fumigatus compared to mDC. In the presence of A. fumigatus, both DC subgroups exhibited up-regulation of genes identified in previous studies as being associated with the exposure of DC to A. fumigatus and exhibiting chemotactic properties for neutrophils, including CXCL2, CXCL5, CCL20, and IL1B. This model closely approximated the human alveolus allowing for an analysis of the host pathogen interface that complements existing animal models of IA