True muonium resonant production at e + e − colliders with standard crossing angle

True muonium (TM) (mu (+) mu (-)) is the heaviest and smallest bound state not containing hadrons, after TM (tau (+ )tau( -)) and mu-tauonium (mu( +/-) tau (sic)). One of the proposed methods to observe the spin 1 fundamental state of TM, which has the smallest lifetime among TM spin 1 states, was to build an e (+) e( -) collider with a large crossing angle (theta similar to 30(degrees)) in order to provide TM with a large boost and detect its decay vertex in e + e -. The following paper will instead show that TM excited states can be observed in relatively large quantities ( O (10)/month) at a e (+) e (-) collider with standard crossing angle, after setting their center-of-mass energy to the TM mass (similar to 2m mu = 211.4 MeV)

True muonium resonant production at e+e−e^+e^- colliders with standard crossing angle

True muonium ($\mu^+\mu^-$) is the heaviest and smallest bound state not involving quantum chromodynamics, after true tauonium ($\tau^+\tau^-$) and mu-tauonium ($\mu^\pm\tau^\mp$). Unlike atoms containing $\tau$ particles, the muon lifetime is long enough to allow observation of true muonium (TM) decays and transitions. One of the proposed methods to observe the spin 1 fundamental state of TM, which has the smallest lifetime among TM spin 1 states, was to build an $e^+e^-$ collider with a large crossing angle ($\theta \sim 30^\circ$) in order to provide TM with a large boost and detect its decay vertex in $e^+ e^-$. The following paper will instead show that TM excited states ($n\geq2$) can be observed in relatively large quantities ($\mathcal{O}$(10)/month) at a feasible $e^+e^-$ collider with standard crossing angles, after setting their center-of-mass energy to the TM mass ($\sim2m_{\mu}=211.4$ MeV)

Crilin: A Semi-Homogeneous Calorimeter for a Future Muon Collider

Calorimeters, as other detectors, have to face the increasing performance demands of the new energy frontier experiments. For a future Muon Collider the main challenge is given by the Beam Induced Background that may pose limitations to the physics performance. However, it is possible to reduce the BIB impact by exploiting some of its characteristics by ensuring high granularity, excellent timing, longitudinal segmentation and good energy resolution. The proposed design, the Crilin calorimeter, is an alternative semi-homogeneous ECAL barrel for the Muon Collider based on Lead Fluoride Crystals (PbF2) with a surface-mount UV-extended Silicon Photomultipliers (SiPMs) readout with an optimized design for a future Muon Collider

Proteasome-mediated degradation of keratins 7, 8, 17 and 18 by mutant KLHL24 in a foetal keratinocyte model: Novel insight in congenital skin defects and fragility of epidermolysis bullosa simplex with cardiomyopathy

Epidermolysis bullosa simplex (EBS) with cardiomyopathy (EBS-KLHL24) is an EBS subtype caused by dominantly inherited, gain-of-function mutations in the gene encoding for the ubiquitin-ligase KLHL24, which addresses specific proteins to proteasomal degradation. EBS-KLHL24 patients are born with extensive denuded skin areas and skin fragility. Whilst skin fragility rapidly ameliorates, atrophy and scarring develop over time, accompanied by life-threatening cardiomyopathy. To date, pathogenetic mechanisms underlying such a unique disease phenotype are not fully characterized. The basal keratin 14 (K14) has been indicated as a KLHL24 substrate in keratinocytes. However, EBS-KLHL24 pathobiology cannot be determined by the mutation-enhanced disruption of K14 alone, as K14 is similarly expressed in foetal and postnatal epidermis and its protein levels are preserved both in vivo and in vitro disease models. In this study, we focused on foetal keratins as additional KLHL24 substrates. We showed that K7, K8, K17 and K18 protein levels are markedly reduced via proteasome degradation in normal foetal keratinocytes transduced with the mutant KLHL24 protein (Delta N28-KLHL24) as compared to control cells expressing the wild-type form. In addition, heat stress led to keratin network defects and decreased resilience in Delta N28-KLHL24 cells. The KLHL24-mediated degradation of foetal keratins could contribute to congenital skin defects in EBS-KLHL24. Furthermore, we observed that primary keratinocytes from EBS-KLHL24 patients undergo accelerated clonal conversion with reduced colony forming efficiency (CFE) and early replicative senescence. Finally, our findings pointed out a reduced CFE in Delta N28-KLHL24-transduced foetal keratinocytes as compared to controls, suggesting that mutant KLHL24 contributes to patients' keratinocyte clonogenicity impairment

Results of the 2022 ECFA Early-Career Researchers Panel survey on career prospects and diversity

This document presents the outcomes of a comprehensive survey conducted among early career researchers (ECRs) in academic particle physics. Running from September 24, 2022, to March 3, 2023, the survey gathered responses from 759 ECRs employed in 39 countries. The study aimed to gain insights into the career prospects and experiences of ECRs while also delving into diversity and sociological aspects within particle physics research. The survey results are presented in a manner consistent with the survey choices. The document offers insights for the particle physics community, and provides a set of recommendations for enhancing career prospects, fostering diversity, and addressing sociological dimensions within this field.Comment: Editors: Julia Allen, Kate\v{r}ina Jarkovsk\'a, Aleksandra Lelek, Holly Pacey, Guillaume Pietrzyk and G\'eraldine R\"aube

Measurement of proton, deuteron, triton, and α particle emission after nuclear muon capture on Al, Si, and Ti with the AlCap experiment

Background: Heavy charged particles after nuclear muon capture are an important nuclear physics background to the muon-To-electron conversion experiments Mu2e and COMET, which will search for charged lepton flavor violation at an unprecedented level of sensitivity. Purpose: The AlCap experiment aimed to measure the yield and energy spectra of protons, deuterons, tritons, and α particles emitted after the nuclear capture of muons stopped in Al, Si, and Ti in the low-energy range relevant for the muon-To-electron conversion experiments. Methods: Individual charged particle types were identified in layered silicon detector packages and their initial energy distributions were unfolded from the observed energy spectra. Results: The proton yields per muon capture were determined as Yp(Al)=26.64(28stat.)(77syst.)×10-3 and Yp(Ti)=26.48(35)(80)×10-3 in the energy range 3.5-20.0 MeV, and as Yp(Si)=52.5(6)(18)×10-3 in the energy range 4.0-20.0 MeV. Detailed information on yields and energy spectra for all observed nuclei are presented in the paper. Conclusions: The yields in the candidate muon stopping targets, Al and Ti, are approximately half of that in Si, which was used in the past to estimate this background. The reduced background allows for less shielding and a better energy resolution in these experiments. It is anticipated that the comprehensive information presented in this paper will stimulate modern theoretical calculations of the rare process of muon capture with charged particle emission and inform the design of future muon-To-electron conversion experiments.</p

Mu2e Crystal Calorimeter Readout Electronics: Design and Characterisation

The Mu2e experiment at Fermi National Accelerator Laboratory will search for the charged-lepton flavour-violating neutrinoless conversion of negative muons into electrons in the Coulomb field of an Al nucleus. The conversion electron with a monoenergetic 104.967 MeV signature will be identified by a complementary measurement carried out by a high-resolution tracker and an electromagnetic calorimeter, improving by four orders of magnitude the current single-event sensitivity. The calorimeter—composed of 1348 pure CsI crystals arranged in two annular disks—has a high granularity, 10% energy resolution and 500 ps timing resolution for 100 MeV electrons. The readout, based on large-area UV-extended SiPMs, features a fully custom readout chain, from the analogue front-end electronics to the digitisation boards. The readout electronics design was validated for operation in vacuum and under magnetic fields. An extensive radiation hardness certification campaign certified the FEE design for doses up to 100 krad and 1012 n1MeVeq/cm2 and for single-event effects. A final vertical slice test on the final readout chain was carried out with cosmic rays on a large-scale calorimeter prototype