Epidemiologic characterization of 30 confirmed cases of human infection with avian influenza A(H7N9) virus in Hangzhou, China

BACKGROUND: We examined the clinical and epidemiological characteristics of 30 cases of human infection with avian influenza A(H7N9) virus in Hangzhou and investigated their external environments to provide evidence for contact tracing and disease prevention and control. METHODS: The cases confirmed from April 1 through May 1, 2013 were studied. Field epidemiologic surveys were conducted to collect the clinical and epidemiologic data. Case-related and environmental specimens were collected for etiologic detection. RESULTS: Thirty cases of human infection with avian influenza A(H7N9) virus were confirmed in Hangzhou from April 1 through May 1, 2013, including one pregnant woman and three deaths. The median age of the patients was 62 years (range: 38–86 years). Twenty-three of the patients were men (76.67%). The median duration between disease onset and occurrence of respiratory failure and confirmed diagnosis was 5 and 6 days, respectively. Maximum medical observation of 666 close contacts of the patients revealed no irregularity. Of 314 external environmental specimens, the overall positive detection rate of H7N9 nucleic acid was 28.98%. Eight districts of Hangzhou city had positive detections in the external environments, the highest rate being in Yuhang District (78.13%). Statistical analysis of the specimen collection locations indicates a significant difference between the case-linked locations and the non-case locations (χ( 2 ) = 16.563, p < 0.05) in terms of H7N9 viral nucleic acid detection rate. No epidemiologic link has been found among the 30 cases. CONCLUSIONS: Most of the infected were retired individuals aged 60 years or older. Men made the majority. The cases are sporadic at present, with no evidence of human-to-human transmission. Exposures to poultry and live poultry markets may be important sources of infection

Baryonium, tetra-quark state and glue-ball in large N_c QCD

From the large-N_c QCD point of view, baryonia, tetra-quark states, hybrids, and glueballs are studied. The existence of these states is argued for. They are constructed from baryons. In N_f=1 large N_c QCD, a baryonium is always identical to a glueball with N_c valence gluons. The ground state 0^{-+} glueball has a mass about 2450 MeV. f_0(1710) is identified as the lowest 0^{++} glueball. The lowest four-quark nonet should be f_0(1370), a_0(1450), K^*_0(1430) and f_0(1500). Combining with the heavy quark effective theory, spectra of heavy baryonia and heavy tetra-quark states are predicted. 1/N_c corrections are discussed.Comment: 16 pages, 3 figure

Design and Implementation of Service-Oriented Expert System

In recent years, the Internet technologies are well developed and the Internet is filled with all kinds of information. Since the data storage is increasingly distributed and data formats are more diverged, data collection and integration for providing value- added services have gradually become important topics. In this study, we propose the Service-Oriented Expert System (SOES) based on Service Component Architecture (SCA) which can make the services on different platforms turn into a common service component on the Internet, concatenate all the service components by combining with the Enterprise Service Bus (ESB), and use both expert rules and data mining techniques to perform the data classification. The SOES is applied to analyze the annual financial information derived from electronic industry in the Taiwan Economic Journal (TEJ) during 2006 to 2008 for discovering the financial crisis enterprises. The experiment results show that using expert rules and decision tree to find the financial crisis enterprise is higher performance

A QoS-Based Services Selected Method in Service-Oriented Architectures Using Ant Colony System - A Case Study of Airflights

Semantic web is becoming more and more popular these days, and it’s an opportune moment to look at the field’s current state and future opportunities. However, most researchers focus on only one single service recommend from semantic web inference. In some situations, the Multi-Services which are combined many complex services from various service providers are better than single service. The designed Multi-Services Semantic Search System (MS4), which provides the cooperation web-based platform for all related mobile users and service providers, could strengthen the ability of Multi-Services suggestion. In this research, MS4 chooses the adaptable airflight as a case study. MS4 is a five-components system composed of the Mobile Users (MUs), UDDI Registries (UDDIRs), Service Providers (SPs), Semantic Web Services Server (SWSS), and Database Server (DS). Using SOA, OWL-S to build semantic web environment to inference user’s requirements and search various web services which are published in UDDI through the communication networks include internet and 3G/GPRS/GSM mobile networks. In this airline case, we propose the Adaptive Airflights Inference Module (AAIM) combined QoS-Based Services Selected Method (QBSSM) using Ant Colony System (ACS) to reference the adaptable airflights to MUs

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.

Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed as a breast cancer predisposition gene, with greater effects for the ER-negative and triple-negative breast cancer (TNBC) subtypes. We tested the three recurrent protein-truncating variants FANCM:p.Arg658*, p.Gln1701*, and p.Arg1931* for association with breast cancer risk in 67,112 cases, 53,766 controls, and 26,662 carriers of pathogenic variants of BRCA1 or BRCA2. These three variants were also studied functionally by measuring survival and chromosome fragility in FANCM -/- patient-derived immortalized fibroblasts treated with diepoxybutane or olaparib. We observed that FANCM:p.Arg658* was associated with increased risk of ER-negative disease and TNBC (OR = 2.44, P = 0.034 and OR = 3.79; P = 0.009, respectively). In a country-restricted analysis, we confirmed the associations detected for FANCM:p.Arg658* and found that also FANCM:p.Arg1931* was associated with ER-negative breast cancer risk (OR = 1.96; P = 0.006). The functional results indicated that all three variants were deleterious affecting cell survival and chromosome stability with FANCM:p.Arg658* causing more severe phenotypes. In conclusion, we confirmed that the two rare FANCM deleterious variants p.Arg658* and p.Arg1931* are risk factors for ER-negative and TNBC subtypes. Overall our data suggest that the effect of truncating variants on breast cancer risk may depend on their position in the gene. Cell sensitivity to olaparib exposure, identifies a possible therapeutic option to treat FANCM-associated tumors

Executable Knowledge Base for Virtual Chat System

A virtual chat system enables the end user to interact with knowledge base by chatting with a virtual assistant. Besides knowledge article, a virtual assistant can also perform automation flows such as restart a virtual machine, reset the password for a PC. In many virtual chat systems, AIML (Artificial Intelligence Markup Language) is used to train the virtual agent to interact with human beings. It is also possible to integrate knowledge system and automation flow system with AIML interpreter to quickly empower virtual assistances with various domain knowledge. The disclosure provides a method to convert or link an automation flow to virtual agent understandable and executable format and enable them to perform and interact seamlessly with the users, the knowledge base system and the automation system

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A&gt;T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

High-Order Synchrosqueezed Chirplet Transforms for Multicomponent Signal Analysis

This study focuses on the analysis of signals containing multiple components with crossover instantaneous frequencies (IF). This problem was initially solved with the chirplet transform (CT). Also, it can be sharpened by adding the synchrosqueezing step, which is called the synchrosqueezed chirplet transform (SCT). However, we found that the SCT goes wrong with the high chirp modulation signal due to the wrong estimation of the IF. In this paper, we present the improvement of the post-transformation of the CT. The main goal of this paper is to amend the estimation introduced in the SCT and carry out the high-order synchrosqueezed chirplet transform. The proposed method reduces the wrong estimation when facing a stronger variety of chirp-modulated multi-component signals. The theoretical analysis of the new reassignment ingredient is provided. Numerical experiments on some synthetic signals are presented to verify the effectiveness of the proposed high-order SCT

Néel Spin Currents in Antiferromagnets

Ferromagnets are known to support spin-polarized currents that control various spin-dependent transport phenomena useful for spintronics. On the contrary, fully compensated antiferromagnets are expected to support only globally spin-neutral currents. Here, we demonstrate that these globally spin-neutral currents can represent the Néel spin currents, i.e., staggered spin currents flowing through different magnetic sublattices. The Néel spin currents emerge in antiferromagnets with strong intrasublattice coupling (hopping) and drive the spin-dependent transport phenomena such as tunneling magnetoresistance (TMR) and spin-transfer torque (STT) in antiferromagnetic tunnel junctions (AFMTJs). Using RuO2 and Fe4GeTe2 as representative antiferromagnets, we predict that the Néel spin currents with a strong staggered spin polarization produce a sizable fieldlike STT capable of the deterministic switching of the Néel vector in the associated AFMTJs. Our work uncovers the previously unexplored potential of fully compensated antiferromagnets and paves a new route to realize the efficient writing and reading of information for antiferromagnetic spintronics