Feed consumption of rats during chronic toxicity test^*.

<p>*Values represent the mean for each group.</p

Histological examination during chronic toxicity test: A–B.

<p>Panels A1–A3 for liver and panels B1–B3 for kidneys tissues. <b>Control (×40), QIG3 6 mo (×40), QIG3 7mo (×40)</b>.</p

Biochemistry parameters in chronic toxicity test.

<p>Values are mean ± SD. *P<0.05 for difference from controls.</p

Body weight changes during chronic toxicity test: A–B.

<p>Panel A for male rats. Panel B for female rats.</p

Scale for tissue sample pathology grading.

<p>Scale for tissue sample pathology grading.</p

Histological and body weight changes in mucosal irritation test: A–C.

<p>Panels A1–A3 show photomicrographs of the colon sections (×10).Panels B1–B3 show photomicrographs of the anus sections (×40). Panel C shows body weight changes.</p

Hematologic measures during the chronic toxicity test.

<p>Values are mean ± SD. *P<0.05 for difference from controls.</p

Standard for Grading pathologic change in mucosal tissue samples.

<p>Standard for Grading pathologic change in mucosal tissue samples.</p

Histological samples from the MTD test: A–C.

<p>Panels A1–A2 show normal liver. Panels B1–B2 show normal kidney and Panels C1–C2 show normal colon tissues. <b>Control (×40), QIG3 (×40)</b>.</p

Signs of acute toxicity test.

<p>Signs of acute toxicity test.</p