Development of particle flow algorithms based on Neural Network techniques for the IDEA calorimeter at future colliders

IDEA (Innovative Detector for an Electron-positron Accelerator) is an innovative general-purpose detector concept, designed to study electron-positron collisions at future e+e− circular colliders. The detector will be equipped with a dual read-out calorimeter able to measure separately the hadronic component and the electromagnetic component of the showers initiated by the impinging hadrons. Particle flow algorithms (PFAs) have become the paradigm of detector design for the high energy frontier and this work focuses on a project to build a particle flow algorithm for the IDEA detector using Machine Learning (ML) techniques. ML is used for particle reconstruction and identification profiting of the high granularity of the fiber-based dual-readout calorimeter. Neural Networks (NN) are built for electron reconstruction inside the calorimeter. The performance of several NN architectures is shown, with particular attention to the layer setup and the activation function choices. The performance is evaluated on the energy resolution function of the reconstructed particles. The algorithm is trained using both parallel CPUs and GPU, and the time performance and the memory usage of the two approaches are systematically compared

SV-IV Peptide1–16 reduces coagulant power in normal Factor V and Factor V Leiden

Native Factor V is an anticoagulant, but when activated by thrombin, Factor X or platelet proteases, it becomes a procoagulant. Due to these double properties, Factor V plays a crucial role in the regulation of coagulation/anticoagulation balance

Low-protein diets for chronic kidney disease patients: The Italian experience

Nutritional treatment has always represented a major feature of CKD management. Over the decades, the use of nutritional treatment in CKD patients has been marked by several goals. The first of these include the attainment of metabolic and fluid control together with the prevention and correction of signs, symptoms and complications of advanced CKD. The aim of this first stage is the prevention of malnutrition and a delay in the commencement of dialysis. Subsequently, nutritional manipulations have also been applied in association with other therapeutic interventions in an attempt to control several cardiovascular risk factors associated with CKD and to improve the patient's overall outcome. Over time and in reference to multiple aims, the modalities of nutritional treatment have been focused not only on protein intake but also on other nutrients

Towards a Muon Collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work.Comment: 118 pages, 103 figure

Towards a muon collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work

Towards a muon collider

A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work