Additional file 1 of Developing and evaluating an interprofessional shared decision-making care model for patients with perinatal depression in maternal care in urban China: a study protocol

Supplementary Material

Table_1_A health economic analysis of an integrated diabetes care program in China: based on real-world evidence.DOCX

IntroductionAn integrated care program was set up in China to improve the collaboration between primary healthcare centers and hospitals on diabetes management. This study aims to evaluate the economic value of this program with real-world data and to examine whether it can be promoted in primary healthcare settings in China.MethodsThis integrated diabetes care program was implemented in Yuhuan City, China, to coordinate primary care and specialty care, treatment and prevention services, as well as the responsibilities of doctors and nurses. Cost-effectiveness analysis was used to compare the short-term economic value of this program (intervention group) versus usual diabetes management (control group). The cost data were collected from a societal perspective, while the effectiveness indicators pointed to the improvement of control rates of fasting blood glucose (FBG), systolic blood pressure (SBP), and diastolic blood pressure (DBP) levels after the 1 year intervention. In addition, cost-utility analysis was applied to evaluate the long-term value of the two groups. Patients’ long-term diabetes management costs and quality-adjusted life years (QALYs) were simulated by the United Kingdom Prospective Diabetes Study Outcomes Model 2.ResultsThe results showed that for 1% FBG, SPB, and DBP control rate improvement, the costs for the intervention group were 290.53, 124.39, and 249.15 Chinese Yuan (CNY), respectively, while the corresponding costs for the control group were 655.19, 610.43, and 1460.25 CNY. Thus, the intervention group’s cost-effectiveness ratios were lower than those of the control group. In addition, compared to the control group, the intervention group’s incremental costs per QALY improvement were 102.67 thousand CNY, which means that the intervention was cost-effective according to the World Health Organization’s standards.DiscussionIn conclusion, this study suggested that this integrated diabetes care program created short-term and long-term economic values through patient self-management support, primary care strengthening, and care coordination. As this program followed the principles of integrated care reform, it can be promoted in China. Also, its elements can provide valuable experience for other researchers to build customized integrated care models.</p

Data_Sheet_1_Analysis of Brain Functional Connectivity Neural Circuits in Children With Autism Based on Persistent Homology.PDF

Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder with a complex and unknown etiology. Statistics demonstrate that the number of people diagnosed with ASD is increasing in countries around the world. Currently, although many neuroimaging studies indicate that ASD is characterized by abnormal functional connectivity (FC) patterns within brain networks rather than local functional or structural abnormalities, the FC characteristics of ASD are still poorly understood. In this study, a Vietoris-Rips (VR) complex filtration model of the brain functional network was established by using resting-state functional magnetic resonance imaging (fMRI) data of children aged 6–13 years old [including 54 ASD patients and 52 typical development (TD) controls] from the Autism Brain Imaging Data Exchange (ABIDE) public database. VR complex filtration barcodes are calculated by using persistent homology to describe the changes in the FC neural circuits of brain networks. The number of FC neural circuits with different length ranges at different threshold values is calculated by using the barcodes, the different brain regions participating in FC neural circuits are discussed, and the connectivity characteristics of brain FC neural circuits in the two groups are compared and analyzed. Our results show that the number of FC neural circuits with lengths of 8–12 is significantly decreased in the ASD group compared with the TD control group at threshold values of 0.7, 0.8 and 0.9, and there is no significant difference in the number of FC neural circuits with lengths of 4–7 and 13–16 and lengths 16. When the thresholds are 0.7, 0.8, and 0.9, the number of FC neural circuits in some brain regions, such as the right orbital part of the superior frontal gyrus, the left supplementary motor area, the left hippocampus, and the right caudate nucleus, involved in the study is significantly decreased in the ASD group compared with the TD control group. The results of this study indicate that there are significant differences in the FC neural circuits of brain networks in the ASD group compared with the TD control group.</p

Additional file 2: Table S2. of GPCR and IR genes in Schistosoma mansoni miracidia

Sequences used for phylogenetic analysis in Fig. 4a. (XLSX 19 kb

Heterogeneously Integrated Laser on Silicon with Non-Volatile Wavelength Tuning

The von-Neumann bottleneck has constrained computing systems from efficiently operating on the increasingly large demand in data from networks and devices. Silicon (Si) photonics offers a powerful solution for this issue by providing a platform for high-bandwidth, energy-efficient interconnects. Furthermore, memristors have emerged as a fundamental building block for non-volatile data storage and novel computing architectures with powerful in-memory processing capabilities. In this paper, we integrate an Al2O3 memristor into a heterogeneous Si quantum dot microring laser to demonstrate the first laser with non-volatile optical memory. The memristor alters the effective optical modal index of the microring laser cavity by the plasma dispersion effect in the high resistance state (HRS) or Joule heating in the low resistance state (LRS), subsequently controlling the output wavelength of the laser in a non-volatile manner. This device enables a novel pathway for future optoelectronic neuromorphic computers and optical memory chips

Additional file 1: of Targeted migration of bone marrow mesenchymal stem cells inhibits silica-induced pulmonary fibrosis in rats

The findings for isolation and characterization in BMSCs. BMSCs exhibited a homogenous spindle-shaped morphology and expressed markers CD44, CD90, CD 11b, and CD45. Fat droplets and calcium were observed, indicating that cultured BMSCs had a strong ability to differentiate into adipogenic and osteogenic mesenchymal lineages. (DOCX 19 kb

Additional file 1: Table S1. of GPCR and IR genes in Schistosoma mansoni miracidia

TMHMM, Phobius and HMMer search results during the identification of putative GPCRs within the S. mansoni genome. (XLSX 98 kb

Table_1_Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China.docx

BackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer in local household registries diagnosed and treated for the first time in the investigating hospital were enrolled from 11 cities in North China between 2010 and 2017. Baseline characteristics and tumor-related information were extracted from the patients’ hospital medical record, clinical course records, and clinical examination. Some of the variables, such as smoking, alcohol consumption, medical history, and family history of cancer, were obtained from interviews with the enrolled patients. The statistical method used were the chi-square test and multi-factor logistic regression analysis. The time trend was statistically analyzed using Joinpoint regression models, and p values were calculated.ResultsA total of 23,674 lung cancer cases were enrolled. People in severely polluted cities were at higher risk for lung adenocarcinoma (p ConclusionsLung adenocarcinoma is the most common histological type of lung cancer in North China (Hebei Province), and the proportion of lung adenocarcinoma is increasing, especially among non-smokers. Lung adenocarcinoma is more common in women, severely polluted cities, individuals with no history of lung-related diseases, in the right lung, and in non-smokers. These can serve as a great guide in determining the accuracy of lung adenocarcinoma high-risk groups and lung cancer risk assessment models.</p

Presentation_1_Epidemiological characteristics and risk factors of lung adenocarcinoma: A retrospective observational study from North China.pptx

BackgroundThe main aim of the study was to determine the risk factors of lung adenocarcinoma and to analyze the variations in the incidence of lung adenocarcinoma according to time, sex, and smoking status in North China.MethodsPatients with lung cancer in local household registries diagnosed and treated for the first time in the investigating hospital were enrolled from 11 cities in North China between 2010 and 2017. Baseline characteristics and tumor-related information were extracted from the patients’ hospital medical record, clinical course records, and clinical examination. Some of the variables, such as smoking, alcohol consumption, medical history, and family history of cancer, were obtained from interviews with the enrolled patients. The statistical method used were the chi-square test and multi-factor logistic regression analysis. The time trend was statistically analyzed using Joinpoint regression models, and p values were calculated.ResultsA total of 23,674 lung cancer cases were enrolled. People in severely polluted cities were at higher risk for lung adenocarcinoma (p ConclusionsLung adenocarcinoma is the most common histological type of lung cancer in North China (Hebei Province), and the proportion of lung adenocarcinoma is increasing, especially among non-smokers. Lung adenocarcinoma is more common in women, severely polluted cities, individuals with no history of lung-related diseases, in the right lung, and in non-smokers. These can serve as a great guide in determining the accuracy of lung adenocarcinoma high-risk groups and lung cancer risk assessment models.</p

Ionotropic Receptors Identified within the Tentacle of the Freshwater Snail <i>Biomphalaria glabrata</i>, an Intermediate Host of <i>Schistosoma mansoni</i>

<div><p><i>Biomphalaria glabrata</i> (<i>B</i>. <i>glabrata</i>) is an air-breathing aquatic mollusc found in freshwater habitats across the Western Hemisphere. It is most well-known for its recognized capacity to act as a major intermediate host for <i>Schistosoma mansoni</i>, the human blood fluke parasite. Ionotropic receptors (IRs), a variant family of the ionotropic glutamate receptors (iGluR), have an evolutionary ancient function in detecting odors to initiate chemosensory signaling. In this study, we applied an array of methods towards the goal of identifying IR-like family members in <i>B</i>. <i>glabrata</i>, ultimately revealing two types, the iGluR and IR. Sequence alignment showed that three ligand-binding residues are conserved in most <i>Biomphalaria</i> iGluR sequences, while the IRs did exhibit a variable pattern, lacking some or all known glutamate-interactingresidues, supporting their distinct classification from the iGluRs. We show that <i>B</i>. <i>glabrata</i> contains 7 putative IRs, some of which are expressed within its chemosensory organs. To further investigate a role for the more ancient <i>IR25a</i> type in chemoreception, we tested its spatial distribution pattern within the snail cephalic tentacle by <i>in situ</i> hybridization. The presence of <i>IR25a</i> within presumptive sensory neurons supports a role for this receptor in olfactory processing, contributing to our understanding of the molecular pathways that are involved in <i>Biomphalaria</i> olfactory processing.</p></div