Observation of the post-tagging effect for entangled K mesons at KLOE

Novel quantum phenomena have been recently discussed in association to a peculiar time correlation between entangled neutral kaons produced at a φ-factory: the past state of the first decayed kaon, when it was still entangled before its decay, is post-tagged by the result and the time of the future observation on the other kaon decay. This surprising ``from future to past'' effect is fully observable. Preliminary results obtained on the analysis of data collected by the KLOE experiment at the DAΦNE collider are presented, showing experimental evidence of this new effect

Can future observation of the living partner post-tag the past decayed state in entangled neutral K-mesons?

Novel quantum phenomena have been recently discussed [1] in association to a peculiar time correlation between entangled neutral kaons produced at a φ-factory: the past state of the first decayed kaon, when it was still entangled before its decay, is post-tagged by the result and the time of the future observation on the other kan decay. This surprising "from future to past" effect is fully observable and leads to the unique experimental tag of the KS state, an unsolved problem since the discovery of CP violation. The first preliminary results obtained on the analysis of data collected by the KLOE experiment at the DAΦNE collider, and showing experimental evidence of this new effect are presented

Testing fundamental physical principles with entangled neutral KK mesons

The neutral kaon doublet is one of the most intriguing systems in nature. En- tangled pairs of neutral K mesons produced in ϕ -meson decays offer a unique possibility to perform important tests of fundamental discrete symmetries as well as of basic principles of quantum mechanics.This paper will focus on a novel method to perform direct T and CPT symmetry tests exploiting the Einstein-Podolsky-Rosen correlations of neutral kaon pairs produced at a ϕ -factory. The statistical significance of the test achievable with the KLOE-2 experiment at DAΦNE, the Frascati ϕ -factory, is also briefly discussed

A direct test of T, CP and CPT symmetries in transitions of neutral kaons with KLOE data

Direct tests of T, CP, CPT symmetries in transitions processes of neutral kaons are briefly reviewed. The exchange of in and out states required for a genuine test involving time-reversal is implemented exploiting the entanglement of pairs produced at a φ-factory. A data sample collected by the KLOE experiment at DAΦNE corresponding to an integrated luminosity of about 1.7 fb−1 is analysed to study the φ → KSKL → π+π− πeν and φ → KSKL → πeν 3π0 processes, and to perform the first direct tests of T and CPT symmetries in kaon transitions with a precision of few percent, and to observe CP violation with this novel method

AFLP analysis to assess genomic stability in Solanum regenerants derived from wild and cultivated species

The cultivated potato as well as its tuber-bearing relatives are considered model plants for cell and tissue culture, and therefore for exploiting the genetic variation induced by in vitro culture. The association between molecular stability and tissue culture in different genetic backgrounds and ploidy levels has already been explored. However, it still remains to be ascertained whether somaclonal variation differs between callus-derived chromosome- doubled and undoubled regenerants. Our research aimed at investigating, through amplified fragment length polymorphism (AFLP) markers, the genetic changes in marker- banding patterns of diploid and tetraploid regenerants obtained from one clone each of Solanum bulbocastanum Dunal and S. cardiophyllum Lindl (both 2n = 2x = 24) and tetraploids from cultivated S. tuberosum L. (2n = 4x = 48). Pairwise comparisons between the banding patterns of regenerants and parents allowed detecting considerable changes associated to in vitro culture both at diploid and tetraploid level. The percentages of polymorphic bands between diploid and tetraploid regenerants were, respectively, 57 and 69% in S. bulbocastanum and 58 and 63% in S. cardiophyllum. On average, the frequencies of lost parental fragments in regenerants were significantly higher than novel bands both in S. bulbocastanum (48 vs. 22%) and S. tuberosum (36 vs. 18%) regenerants. By contrast, in S. cardiophyllum, a similar incidence of the two events was detected (32 vs. 29%). Our results revealed that structural changes after tissue culture process strongly affected the genome of the species studied, but diploid and tetraploids regenerated plants responded equally

Interspecific somatic hybrids between Solanum bulbocastanum and S. tuberosum and their haploidization for potato breeding.

Protoplast fusion between incongruent Solanum bulbocastanum and S. tuberosum haploids was accomplished to produce hybrids combining elite traits from both parents. We identified 11 somatic hybrids out of 42 regenerants analyzed through ISSR markers. Some hybrids had loss or gain of fragments compared to the parents, likely due to rearrangements and deletions of chromosome segments after fusion, and/or to somaclonal variation during hybrid regeneration. Increased heterotic vigor for some traits as well as high diversity was observed as the effect of both ploidy and fusion combination. Microsporogenesis analysis indicated the occurrence of multivalent configurations and several meiotic abnormalities, such as chromosomes bridges and various spindle orientations. Since all hybrids were sterile, in vitro anther culture was employed for haploidization as a possible strategy to overcome barriers to hybridizations. Haploids were obtained from all the tetraploid S. bulbocastanum (+) S. tuberosum somatic hybrids tested, although with differences in both the number of embryos per 100 anthers cultured and the number of differentiated green plantlets. This is the first report on the successful production of haploid plants from S. bulbocastanum (+) S. tuberosum hybrids

Resistance to Ralstonia Solanacearum of sexual hybrids between Solanum commersonii and S. tuberosum

This research was carried out to study the levels of bacterial wilt resistance and genetic diversity of (near) pentaploid sexual hybrids between S. commersonii (2n = 2x = 24, 1EBN) and cultivated S. tuberosum. Following artificial inoculations with Ralstonia solanacearum, wilting degree was estimated on a scale from 0 to 4, and seven genotypes of 26 (27%) displaying a S. commersonii like behavior were identified. Latent bacterial colonizations were detected in roots of symptomless S. commersonii and hybrids, whereas no bacterial populations were detected within stems. This suggests that the movement and/or growth of the bacterium in the aerial part were strongly inhibited. A molecular study with AFLP markers clustered hybrids into nine groups and provided evidence that resistant hybrids were slightly more similar to cultivated S. tuberosum than to the wild parent. This is important in view of the re-establishment of the cultivated genetic background through backcrosses. Hybrids displayed good fertility and are being used for further breeding efforts

Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease

Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients. AGEs proved to be a marker of negative outcome in both diabetes management and surgical procedures in these patients. The reported role of AGEs prompted the development of pharmacological inhibitors of their effects, giving rise to a number of both preclinical and clinical studies. Clinical trials with anti-AGEs drugs have been gradually developed and this review aimed to summarize most relevant reports