Comment on "The Lamb Shift and Ultra High Energy Cosmic Rays" and Comment on "Vacuum Polarization Energy Losses of High Energy Cosmic Rays"

The cosmic rays spectrum has been shown to extend well beyond 10^20 eV. With nearly 20 events observed in the last 40 years, it is now established that particles with energies near or above 10^21 eV. No nearby astrophysical object has been shown to correlate with the arrival directions of the highest energy events, yet the exponential cut-off in the high energy end of the spectrum one expects to see in the case of far sources is not visible. It was recently pointed out that the influence of the vacuum of quantum electrodynamics on particle propagation could explain qualitatively this mystery. This note is a critic to these ideas.Comment: 4 pages, note on second paper correcte

Searches for Large-Scale Anisotropies of Cosmic Rays: Harmonic Analysis and Shuffling Technique

The measurement of large scale anisotropies in cosmic ray arrival directions is generally performed through harmonic analyses of the right ascension distribution as a function of energy. These measurements are challenging due to the small expected anisotropies and meanwhile the relatively large modulations of observed counting rates due to experimental effects. In this paper, we present a procedure based on the shuffling technique to carry out these measurements, applicable to any cosmic ray detector without any additional corrections for the observed counting rates.Comment: 22 pages, 10 figures, to appear in Astroparticle Physic

Estimates of multipolar coefficients to search for cosmic ray anisotropies with non-uniform or partial sky coverage

We study the possibility to extract the multipolar moments of an underlying distribution from a set of cosmic rays observed with non-uniform or even partial sky coverage. We show that if the degree is assumed to be upper bounded by $L$, each multipolar moment can be recovered whatever the coverage, but with a variance increasing exponentially with the bound $L$ if the coverage is zero somewhere. Despite this limitation, we show the possibility to test predictions of a model without any assumption on $L$ by building an estimate of the covariance matrix seen through the exposure function.Comment: 20 pages, 8 figure

UHE tau neutrino flux regeneration while skimming the Earth

The detection of Earth-skimming tau neutrinos has turned into a very promising strategy for the observation of ultra-high energy cosmic neutrinos. The sensitivity of this channel crucially depends on the parameters of the propagation of the tau neutrinos through the terrestrial crust, which governs the flux of emerging tau leptons that can be detected. One of the characteristics of this propagation is the possibility of regeneration through multiple $\nu_\tau \leftrightarrow \tau$ conversions, which are often neglected in the standard picture. In this paper, we solve the transport equations governing the $\nu_\tau$ propagation and compare the flux of emerging tau leptons obtained allowing regeneration or not. We discuss the validity of the approximation of neglecting the $\nu_\tau$ regeneration using different scenarios for the neutrino-nucleon cross-sections and the tau energy losses.Comment: 8 pages, 8 figure

A phenomenological model of the muon density profile on the ground of very inclined air showers

Ultra-high energy cosmic rays generate extensive air showers in Earth's atmosphere. A standard approach to reconstruct the energy of an ultra-high energy cosmic rays is to sample the lateral profile of the particle density on the ground of the air shower with an array of surface detectors. For cosmic rays with large inclinations, this reconstruction is based on a model of the lateral profile of the muon density observed on the ground, which is fitted to the observed muon densities in individual surface detectors. The best models for this task are derived from detailed Monte-Carlo simulations of the air shower development. We present a phenomenological parametrization scheme which allows to derive a model of the average lateral profile of the muon density directly from a fit to a set of individual Monte-Carlo simulated air showers. The model reproduces the detailed simulations with a high precision. As an example, we generate a muon density model which is valid in the energy range 1e18 eV < E < 1e20 eV and the zenith angle range 60 deg < theta < 90 deg. We will further demonstrate a way to speed up the simulation of such muon profiles by three orders of magnitude, if only the muons in the shower are of interest.Comment: Corresponding author: Hans Dembinsk

In Antisynthetase Syndrome, ACPA Are Associated With Severe and Erosive Arthritis: An Overlapping Rheumatoid Arthritis and Antisynthetase Syndrome

International audienceAbstract: Anticitrullinated peptide/protein antibodies (ACPA), which are highly specific for rheumatoid arthritis (RA), may be found in some patients with other systemic autoimmune diseases. The clinical significance of ACPA in patients with antisynthetase syndrome (ASS), a systemic disease characterized by the association of myositis, interstitial lung disease, polyarthralgia, and/or polyarthritis, has not yet been evaluated with regard to phenotype, prognosis, and response to treatment. ACPA-positive ASS patients were first identified among a French multicenter registry of patients with ASS. Additionally, all French rheumatology and internal medicine practitioners registered on the Club Rhumatismes et Inflammation web site were asked to report their observations of ASS patients with ACPA. The 17 collected patients were retrospectively studied using a standardized questionnaire and compared with 34 unselected ACPA-negative ASS patients in a case–control study. All ACPA-positive ASS patients suffered from arthritis versus 41% in the control group (P 7-year mean follow-up, extra-articular outcomes and survival were not different. ACPA-positive ASS patients showed an overlapping RA–ASS syndrome, were at high risk of refractory erosive arthritis, and might experience ASS flare when treated with antitumor necrosis factor drugs. In contrast, other biologics such as anti-CD20 mAb were effective in this context, without worsening systemic involvements

A finite element/quaternion/asymptotic numerical method for the 3D simulation of flexible cables

A flexible cable is modeled by a geometrically exact beam model with 3D rotations described using quaternion parameters. The boundary value problem is then discretized by the finite element method. The use of an asymptotic numerical method to solve the problem, quadratic equations, is well suited to the quaternion parametrization. This combination of methods leads to a fast, robust and accurate algorithm very well-adapted for the simulation of the assembly process of cables. This is proved by running many examples involving complicated solutions

Observational Constraints on Cosmic-Ray Escape from Ultrahigh-energy Accelerators

Interactions of ultra-high energy cosmic rays (UHECRs) accelerated in specific astrophysical environments have been shown to shape the energy production rate of nuclei differently from that of the secondary neutrons escaping from the confinement zone. Here, we aim at testing a generic scenario of in-source interactions through phenomenological modeling of the flux and composition of UHECRs. We fit a model in which nucleons and nuclei follow different particle energy distributions to the all-particle energy spectrum and proton spectrum below the ankle energy and distributions of maximum shower depths above this energy, as inferred at the Pierre Auger Observatory. We obtain that the data can be reproduced using a spatial distribution of sources that follows the density of extragalactic matter on both local and large scales, providing hence a realistic set of constraints for the emission mechanisms in cosmic accelerators, for their energetics, and for the abundances of elements at escape from their environments. While the quasi monoelemental increase of the cosmic-ray mass number observed on Earth from ≃2 EeV up to the highest energies calls for nuclei accelerated with a hard spectral index, the inferred flux of protons down to ≃0.6 EeV is shown to require for this population a spectral index significantly softer than that generally obtained up to now. We demonstrate that modeling UHECR data across the ankle substantiates the conjecture of in-source interactions in a robust statistical framework, although pushing the mechanism to the extreme