New Exhibit at the Zoo

Poetry by Matthew Del Busto

Interview with Robert Wrigley

Robert Wrigley is the author of numerous collections of poetry, most recently Anatomy of Melancholy & Other Poems (2013), which won him the Pacific Northwest Book Award. During his visit to Butler, Wrigley sat down to talk with Manuscripts staff member Matt Del Busto about his most recent collection, titled after Robert Burton’s The Anatomy of Melancholy, written almost 400 years prior. They discussed the power of poetry and melancholy in our lives. In 2016, Wrigley retired from a forty-year teaching career and currently lives in Idaho “in the woods on the side of a mountain” with his wife

Flash as Fiction: Exploring Jennifer Egan’s nuanced portrayal of photography

Photographs are everywhere. They’re blown up on billboards, airdropped via iPhones, and slapped on the sides of semis, telling stories of war, politics, sport, and most everything in between. Yet, how much credence should we allow photographs, which display not reality itself but a two-dimensional abstraction of a single moment’s reality? As the ubiquitousness of images continues to increase, it is more critical now than ever to understand photography as a cultural force having measurable influence on both society as a whole and the individuals within it. In the writing of Pulitzer Prize-winning author Jennifer Egan, ideas about photography and images are woven into her work, implying a nuanced truth: while photography can capture a moment’s truth in perpetuity or manipulate generations to come by presenting a contrived reality, people’s experiences with photography generally land somewhere between truth and manipulation. As such, this paper will briefly explore photography’s omnipresence and its implications on present-day society. Further, close reading practices coupled with careful textual analysis of key moments in Egan’s work will investigate how she describes images and photography within her texts and what she suggests to us, as readers, regarding our relation to the world, to the photograph, and to one another. This research and analysis will allow me to investigate if, as Egan writes in her novel Look at Me (2001), “we are what we see” (p. 390) in order to examine how we understand reality and what role we should allow the camera to play in our photo-centric society

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Oratory

Master of Fine Arts (MFA)English Language and LiteratureUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/172899/1/Oratory_Del_Busto_Thesis.pdfDescription of Oratory_Del_Busto_Thesis.pdf : Restricted to UM users only

Assessment of changes in autophagic vesicles in human immune cell lines exposed to nano particles

Abstract Background Safe and rational development of nanomaterials for clinical translation requires the assessment of potential biocompatibility. Autophagy, a critical homeostatic pathway intrinsically linked to cellular health and inflammation, has been shown to be affected by nanomaterials. It is, therefore, important to be able to assess possible interactions of nanomaterials with autophagic processes. Results CEM (T cell), Raji (B lymphocyte), and THP-1 (human monocyte) cell lines were subject to treatment with rapamycin and chloroquine, known to affect the autophagic process, in order to evaluate cell line-specific responses. Flow cytometric quantification of a fluorescent autophagic vacuole stain showed that maximum observable effects (105%, 446%, and 149% of negative controls) were achieved at different exposure durations (8, 6, and 24 h for CEM, Raji, and THP-1, respectively). THP-1 was subsequently utilised as a model to assess the autophagic impact of a small library of nanomaterials. Association was observed between hydrodynamic size and autophagic impact (r2 = 0.11, p = 0.004). An ELISA for p62 confirmed the greatest impact by 10 nm silver nanoparticles, abolishing p62, with 50 nm silica and 180 nm polystyrene also lowering p62 to a significant degree (50%, 74%, and 55%, respectively, p < 0.05). Conclusions This data further supports the potential for a variety of nanomaterials to interfere with autophagic processes which, in turn, may result in altered cellular function and viability. The association of particle size with impact on autophagy now warrants further investigation. Graphic abstrac