P63 marker Expression in Usual Skin Cancers Compared With Non Tumoral Skin Lesions

Background: Non-melanoma skin cancers including basal cell carcinoma and squamous cell carcinoma are the most common malignant diseases in human. The aim of this study was to determine the expression of the P63 marker in common skin cancers and non-tumoral skin lesions and compared the difference between them. Materials and Methods: In this cross-sectional study, sampling was performed from the archive of sample blocks from patients admitted in Shahid Mohammadi Hospital during 2010-2011. Sixty samples (including 30 samples of non-tumoral skin lesions and 30 samples including basal cell carcinoma and squamous cell carcinoma) were studied. The evaluation of p63 gene expression was performed using immunohistochemistry method. Student’s T-test and Chi-square test were used for analysis of the data. Results: P63 gene were expressed in 4 cases (13.33 %) of non_tumoral lesions and all tumoral lesions (100%). In tumoral lesions, 5 cases (16.66 %) showed 1+ severity expression, 11 cases (36.66%) 2+severity expression and 14 cases (46.66 %) 3+severity expression. All 4 non-tumoral lesions showed 1+severity expression of P63gene. Conclusion: The results of this study indicated that the frequency and severity of gene expression of P63 could be used for differentiation between basal cell carcinoma and squamous cell carcinoma as well as non-tumoral skin lesions

Three-dimensional black holes with scalar hair coupled to a Maxwell-like electrodynamics

By consideration of a Einstein-dilaton non-linear charged gravitating system, it has been shown that this theory is confronted with the problem of indeterminacy. It means that the number of independent differential equations is one less than the number of unknowns. To overcome this problem, the power-law and exponential ansatz functions have been used, separately. Through solving the field equations, in the presence of a Coulomb-like electric field, it has been found that this theory includes two novel classes of charged black holes (BHs) with unusual asymptotic behavior, for each ansatz. It has been found that, under some circumstances, both of the ansatz functions lead to the same results. The novel exact solutions show BHs with one horizon, two horizons and without horizon. Using a Smarr-type mass formula validity of the first law of BH thermodynamics (FLT) has been proved, after calculating the thermodynamic and conserved quantities. Making use of thermodynamical and geometrical approaches, thermal stability of the BHs has been analyzed. Results of the aforementioned methods have been compared by use of the plots.Comment: 18 pages with 6 figures. Accepted by MPL

Bioaccumulation of heavy metals in eight fish species of the Khur-e Khuran International Wetland in the Persian Gulf, Iran

Heavy metals are among the most toxic pollutants in aquatic ecosystems. This study was conducted to evaluate the concentration of heavy metals viz. lead, cadmium, chromium, zinc, cobalt, and copper in eight commercial fishes of Khur-e Khuran international wetland (KIW), Iran. The results showed that the highest concentration of heavy metals attributed to Zn as 176.5 µg g-1 dry weight in Platycephalus indicus and the lowest to Pb as 0.12 µg g-1 dry weight in Sillago sihama. Average concentrations of heavy metals in eight examined fish species were 29.15, 49.73, 1.39, 0.45, 1.43 and 1.56 µg g-1 dry weight for Cu, Zn, Cd, Pb, Co and Cr, respectively. The results also show that measured values of most heavy metals in some examined fishes of KIW were higher than those maximum permissible limit (MPL) according to international standards. The high concentrations of some metals in some examined fishes of KIW may be due to industrial and residential activities in adjacent coast i.e. in mainland and Qeshm Island, and marine traffi

The clinical presentation of Post-Transplant Lymphoproliferative Disorder (PTLD) following pediatric liver transplantation

Post-transplant lymphoproliferative disorder is a life-threatening complication of solid organ transplantation. In pediatric recipients, PTLD has been reported in 6.4-19.5 of lung, heart and heart-lung transplants, 4-15 of liver transplants and 1.2-10.1 of kidney transplants. Although most lymphomas typically occur in lymph nodes, extranodal involvement is also common. The aim of our study was to determine the site and symptoms of PTLD in children who underwent liver transplantation during 2009-2012 in Liver Transplantation Center of Nemazee Hospital. Material and methods: This study is a cohort study on existing data of children who received liver transplant between Juanury 2009 and December 2012 at Liver Transplant Center of Nemazee Hospital in Shiraz. During the study period, the PTLD occurrence was assessed in follow up visits, if the diagnosis of PTLD was confirmed the affected patient was entered the study and additional information was obtained. The diagnosis of PTLD was considered in patients with fever of undetermined origin, lymphadenopathy, allograft dysfunction, and pulmonary infiltrates. The data was analyzed using SPSS software ver.18. Statistical descriptive methods, Chi square test, and independent t-test, were used for analyzing the data. P value smaller than 0.05 were considered significant. Results: Totally, 203 children undergoing liver transplant surgery were evaluated. The age range of patients was 8 months to 18 years with mean of 8.8±5.6 years old. In our study 17 (8.4) patients developed PTLD. The mean interval between transplantation and PTLD diagnosis was 8.4 ±5.61 months ranging from 4 to 24 months. A total of five patients (2.5) died during the follow-up period and all of them were PTLD affected children (29.4 of PTLD patients). Lymph nodes were the most predominant site involved (64.7), while liver and GI involved in 35.2. Conclusion: The results of this study emphasize the relatively high incidence of PTLD after liver transplantation in children. Because of its impact on patient's outcome and reducing recipient's survival, it is important to minimize this problem by early diagnosis and providing effective treatment

Effects of Environmental Factors on the Growth, Optical Density and Biomass of the Green Algae Chlorella Vulgaris in Outdoor Conditions

Effect of environmental factors on the growth of the Chlorella vulgaris was studied. C. vulgaris was  cultivated in sterilized natural seawater enriched with F/2-Si medium. Then grow in bucket, tub and photobioreactor (PBR) in outdoor condition. The daily routine work consisted of culture checkups of optical density, biomass gains, atmosphere lux, culture lux, atmosphere temperature and culture temperature  were recorded. The highest biomass yields were (3.0 μg/ml-1) in December and (2.01 μg/ml-1) in November in PBR. The highest deviation was in atmosphere lux in time 8:30 (± 117.7) and lowest  deviation was in atmosphere temperature in time 15:00 (± 1.0499). Optical density (OD) indicated that the best growth of C. vulgaris in outdoor condition was obtained in 650 lux and also it increased with increasing amount of lux. Tub report of C. vulgaris showed different growing behaviors at the various concentration of light and at the different temperatures. Algal production in outdoor PBR is relatively inexpensive, but is only suitable for a few, fast-growing specie. Finally, this fact is noteworthy that in outdoor conditions, temperature and light have important role in growth of C. vulgaris in present study.  ©JASEMKeywords: Chlorella vulgaris, Biomass, Photobioreactor, Growth

Studying the environmental health status of beauty salons of Kashan

Background and aims: Beauty salons are considered as the places which the environmental health and renovation are adhered too. they can improve the society’s health and influence controlling the diseases. Not considering this issue causes the spread of skin and hair diseases and infections and louse. This study was aimed to determine the health status of beauty salons of Kashan in 2014. Methods: This descriptive-analytical study was done in 2014 in Kashan. Out of 320 beauty salons in Kashan, 220 were selected at random. Collecting the data was through observation, interview, filling the questionnaires and check lists in the beauty salons. Data collection was done on the basis of the environmental health evaluation form for beauty salons. The check list related to each beauty salon was completed and the data were analyzed by SPSS software. Results: The results of this study showed that 45.5 of the salon employees had participated in the special course of public health and 54.5 had personal health card. Fifty one point four percent of them were acceptable in terms of personal hygiene and 52.7 shared the tools and equipment. Half of the beauty salons had been sanitized and 52.3 of them had soaps and towels. Conclusion: The results showed that the beauty salons in Kashan had acceptable building status. Some personal hygiene factors such as personal health card, public health certificate and observing personal hygiene needs more training. Also, more supervision and inspection must be carried out by the environmental health experts

A Regularized Interior-Point Method for Constrained Linear Least Squares

RÉSUMÉ : Nous proposons une méthode de points intérieurs non réalisable pour le problème aux moindres carrés linéaire avec contraintes basée sur la régularisation primale-duale de problèmes quadratiques convexes de Friedlander et Orban (2012). À chaque itération, la méthode effectue une factorisation LDLT creuse d’une matrice symétrique et quasi définie. Cette matrice est uniformément bornée et non singulière. Nous établissons des conditions sous lesquelles la méthode produit une solution du problème original. La régularisation nous permet d’éliminer l’hypothèse que les gradients actifs sont linéairement indépendants. Bien que l’implémentation proposée ici repose sur une factorisation, elle ouvre la voie à une implémentation itérative dans laquelle on résout un problème aux moindres carrés régularisé sans contraintes de façon inexacte à chaque itération. Nous illustrons notre approche sur plusieurs applications qui mettent en évidence ses avantages.----------ABSTRACT : We propose an infeasible interior-point algorithm for constrained linear least-squares problems based on the primal-dual regularization of convex programs of Friedlander and Orban (2012). At each iteration, the sparse LDLT factorization of a symmetric quasi-definite matrix is computed. This coefficient matrix is shown to be uniformly bounded and nonsingular. We establish conditions under which a solution of the original problem is recovered. The regularization allows us to dispense with the assumption that the active gradients are linearly independent. Although the implementation described here is factorization based, it paves the way for a matrix-free implementation in which a regularized unconstrained linear least-squares problem is solved at each iteration. We report on computational experience and illustrate the potential advantages of our approach