Children’s Social Behaviors and Peer Interactions in Diverse Cultures

This chapter lays out five principles to guide research on peer relationships in cultural context that reflect both current and earlier bodies of research literature: (1) Cultural scripts for socialization in peer relationships are evident in early childhood. (2) Both across and within cultural communities, children’s own active role in the socialization process becomes increasingly evident as they grow older. (3) Because children are active agents in their own socialization, they can not only make choices, they can also negotiate, deflect, and resist socializing attempts by others. (4) Children’s choices and preferences (self-socialization) during middle childhood have measurable and lasting effects on their developmental outcomes during adolescence. (5) Periods of rapid social change create exceptional stresses as well as opportunities for childhood peers

A Participatory Action Research Study of Police Interviewing Following Crisis Intervention Team Training

Estimates vary, but a third to one half of individuals shot and killed by police have a mental illness or disability, and many who are taken into custody languish in county jails where no treatment for their illness is available. The Crisis Intervention Team (CIT) model is an increasingly important adjunct to U.S. police training because it de-escalates tense situations, diverts people with mental illness away from jail and into treatment, and can reduce the risk of civilian deaths during a police encounter. As such, it is a strategy for reducing the social injustice of incarceration or deaths of people with mental illness during police encounters. Studies of CIT effectiveness are challenging due to mistrust between law enforcement and the community, policy that limits communication (including a hierarchical structure), and the danger involved in observing police behavior in the field. As a result, studies of CIT effectiveness typically rely on a survey of the CIT officers and do not observe behavior in the field to confirm reported changes. In this small participatory action research (PAR) study, we used a community-based participatory research method featuring “ride-along” observations of CIT-trained officers and untrained officers to examine the various effects of CIT training in one U.S. metropolitan community. We documented some evidence of changes in community relationships, as well as different interviewing styles among police officers following CIT training. CIT training increased the length of interviewing time and resulted in more diversions away from jails

(Mis)Communicating with Geographic Information System Mapping: Part 1--Choosing Units of Representation

Extension professionals are increasingly using geographic information system (GIS) technology to develop and inform programs and services. In this article, we use a mapping exercise to demonstrate how the unit of data can be applied and inadvertently misrepresented in GIS mapping. We contrast the use of counts, percentages, and location quotients with the same data and the resulting divergence in maps. The discussion addresses ideal circumstances for using each unit of data. Overall, the article illustrates the need for Extension professionals to be cognizant of the benefits and limitations of various units of data to avoid miscommunication when using GIS mapping

(Mis)Communicating with Geographic Information System Mapping: Part 2—Determining Data Cutoffs

The increasing use of geographic information system (GIS) technology in various fields suggests the need for professionals, including those in Extension, to be mindful of communicating data accurately and effectively. This article examines approaches to creating classes or groupings within data as well as the weaknesses of each approach. Data break units discussed in the article include equal intervals, quantiles, and units resulting from natural breaks. Ideal situations for each type of data break are presented. The article emphasizes the need for Extension professionals to consider the effects of data grouping to avoid miscommunication when using GIS mapping

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

BACKGROUNDUndifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.METHODSSixty-six consecutively referred USAID patients underwent underwent screening for the presence of an interferon signature using a standardized type-I IFN-response-gene score (IRG-S), cytokine profiling, and genetic evaluation by next-generation sequencing.RESULTSThirty-six USAID patients (55%) had elevated IRG-S. Neutrophilic panniculitis (40% vs. 0%), basal ganglia calcifications (46% vs. 0%), interstitial lung disease (47% vs. 5%), and myositis (60% vs. 10%) were more prevalent in patients with elevated IRG-S. Moderate IRG-S elevation and highly elevated serum IL-18 distinguished 8 patients with pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS). Among patients with panniculitis and progressive cytopenias, 2 patients were compound heterozygous for potentially novel LRBA mutations, 4 patients harbored potentially novel splice variants in IKBKG (which encodes NF-κB essential modulator [NEMO]), and 6 patients had de novo frameshift mutations in SAMD9L. Of additional 12 patients with elevated IRG-S and CANDLE-, SAVI- or Aicardi-Goutières syndrome-like (AGS-like) phenotypes, 5 patients carried mutations in either SAMHD1, TREX1, PSMB8, or PSMG2. Two patients had anti-MDA5 autoantibody-positive juvenile dermatomyositis, and 7 could not be classified. Patients with LRBA, IKBKG, and SAMD9L mutations showed a pattern of IRG elevation that suggests prominent NF-κB activation different from the canonical interferonopathies CANDLE, SAVI, and AGS.CONCLUSIONSIn patients with elevated IRG-S, we identified characteristic clinical features and 3 additional autoinflammatory diseases: IL-18-mediated PAP and recurrent MAS (IL-18PAP-MAS), NEMO deleted exon 5-autoinflammatory syndrome (NEMO-NDAS), and SAMD9L-associated autoinflammatory disease (SAMD9L-SAAD). The IRG-S expands the diagnostic armamentarium in evaluating USAIDs and points to different pathways regulating IRG expression.TRIAL REGISTRATIONClinicalTrials.gov NCT02974595.FUNDINGThe Intramural Research Program of the NIH, NIAID, NIAMS, and the Clinical Center

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Remembering Hawaii Statehood in Hawaii's English-Language Newspapers: How Biased Newspaper Coverage Affects Historical Narrative Creation

The overthrow of the Hawaiian Monarchy in 1893 set off a series of events that ultimately resulted in Hawai’i becoming known as the 50th state of the United States. One of the last of these events was a referendum, a vote by residents of Hawai’i, on the Hawaii Admission Act that was signed into law by President Eisenhower in 1959. Given only the choice of accepting the act and becoming a state, or rejecting it and remaining a territory, an overwhelming majority voted in favor of the act. Over 50 years later, Hawaii Statehood remains controversial due to a belief that Hawai’i never legally became a state and that it has been illegally occupied by the United States since 1898. Although there is a consensus among scholars that the two main English-language newspapers in Hawai’i were biased in favor of Hawaii Statehood, there is little scholarship on how this media bias affects the public memory of this event

(Mis)Communicating with Geographic Information System Mapping: Part 1--Choosing Units of Representation

Extension professionals are increasingly using geographic information system (GIS) technology to develop and inform programs and services. In this article, we use a mapping exercise to demonstrate how the unit of data can be applied and inadvertently misrepresented in GIS mapping. We contrast the use of counts, percentages, and location quotients with the same data and the resulting divergence in maps. The discussion addresses ideal circumstances for using each unit of data. Overall, the article illustrates the need for Extension professionals to be cognizant of the benefits and limitations of various units of data to avoid miscommunication when using GIS mapping

(Mis)Communicating with Geographic Information System Mapping: Part 2—Determining Data Cutoffs

The increasing use of geographic information system (GIS) technology in various fields suggests the need for professionals, including those in Extension, to be mindful of communicating data accurately and effectively. This article examines approaches to creating classes or groupings within data as well as the weaknesses of each approach. Data break units discussed in the article include equal intervals, quantiles, and units resulting from natural breaks. Ideal situations for each type of data break are presented. The article emphasizes the need for Extension professionals to consider the effects of data grouping to avoid miscommunication when using GIS mapping