Demographic, tumor and clinical features of clinical trials versus clinical practice patients with HER2-positive early breast cancer: results of a prospective study

Several randomized clinical trials (RCTs) have demonstrated the efficacy of trastuzumab-based adjuvant therapy in HER2-positive breast cancer (BC). However, RCT patients may not invariably be representative of patients routinely seen in clinical practice (CP). To address this issue, we compared the clinical and tumor features of RCT and CP patients with HER2-positive BC

Farmacovigilancia: ¿Qué es cómo aplicarla en un servicio farmacéutico de baja complejidad?

Aplicar un programa de farmacovigilancia en la droguería de parque campestre de farmacenter aplicando los procesos más eficaces para ponerlo en desarrollo el cual se debe enfatizar en aplicacion diaria la farmacovigilancia, garantizando que los profesionales sean los primeros en tener conocimiento suficiente para llevar a cabo sus actividades diarias con éxito.Apply a pharmacovigilance program in the drugstore of Parque Campestre de Farmacenter, applying the most effective processes to put it into development, which should be emphasized in daily application of pharmacovigilance, guaranteeing that professionals are the first to have sufficient knowledge to carry out their activities. successful daily

Precision determination of electroweak parameters and the strange content of the proton from neutrino deep-inelastic scattering

We use recent neutrino dimuon production data combined with a global deep-inelastic parton fit to construct a new parton set, NNPDF1.2, which includes a determination of the strange and antistrange distributions of the nucleon. The result is characterized by a faithful estimation of uncertainties thanks to the use of the NNPDF methodology, and is free of model or theoretical assumptions other than the use of NLO perturbative QCD and exact sum rules. Better control of the uncertainties of the strange and antistrange parton distributions allows us to reassess the determination of electroweak parameters from the NuTeV dimuon data. We perform a direct determination of the |V_cd| and |V_cs| CKM matrix elements, obtaining central values in agreement with the current global CKM fit: specifically we find |V_cd|=0.244\pm 0.019 and |V_cs|=0.96\pm 0.07. Our result for |V_cs| is more precise than any previous direct determination. We also reassess the uncertainty on the NuTeV determination of \sin^2\theta_W through the Paschos-Wolfenstein relation: we find that the very large uncertainties in the strange valence momentum fraction are sufficient to bring the NuTeV result into complete agreement with the results from precision electroweak data.Comment: 46 pages, 20 figures; fig.12 and discussion on positivity added, several typos corrected. Final version, to be published in Nucl. Phys.

Quality of residential facilities in Italy: satisfaction and quality of life of residents with schizophrenia spectrum~disorders

Background Recovery and human rights promotion for people with Schizophrenia Spectrum Disorders (SSDs) is fundamental to provide good care in Residential Facilities (RFs). However, there is a concern about rehabilitation ethos in RFs. This study aimed to investigate the care quality of Italian RFs, the quality of life (QoL) and care experience of residents with SSD. Methods Fourty-eight RFs were assessed using a quality assessment tool (QuIRC-SA) and 161 residents with SSD were enrolled. Seventeen RFs provided high intensity rehabilitation (SRP1), 15 medium intensity (SRP2), and 16 medium-low level support (SRP3). Staff-rated tools measured psychiatric symptoms and psychosocial functioning; user-rated tools assessed QoL and satisfaction with services. RFs comparisons were made using ANOVA and Chi-squared. Results Over two-thirds patients (41.5 y.o., SD 9.7) were male. Seventy-six were recruited from SRP1 services, 48 from SRP2, and 27 from SRP3. The lowest QuIRC-SA scoring was Recovery Based Practice (45.8%), and the highest was promotion of Human Rights (58.4%). SRP2 had the lowest QuIRC-SA ratings and SRP3 the highest. Residents had similar psychopathology (p = 0.140) and functioning (p = 0.537). SRP3 residents were more employed (18.9%) than SRP1 (7.9%) or SRP2 (2.2%) ones, and had less severe negative symptoms (p = 0.016) and better QoL (p = 0.020) than SRP2 residents. There were no differences in the RF therapeutic milieu and their satisfaction with care. Conclusions Residents of the lowest supported RFs in Italy had less severe negative symptoms, better QoL and more employment than others. The lowest ratings for Recovery Based Practice across all RFs suggest more work is needed to improve recovery

Entanglement negativity in a two dimensional harmonic lattice: Area law and corner contributions

We study the logarithmic negativity and the moments of the partial transpose in the ground state of a two dimensional massless harmonic square lattice with nearest neighbour interactions for various configurations of adjacent domains. At leading order for large domains, the logarithmic negativity and the logarithm of the ratio between the generic moment of the partial transpose and the moment of the reduced density matrix at the same order satisfy an area law in terms of the length of the curve shared by the adjacent regions. We give numerical evidence that the coefficient of the area law term in these quantities is related to the coefficient of the area law term in the R\ue9nyi entropies. Whenever the curve shared by the adjacent domains contains vertices, a subleading logarithmic term occurs in these quantities and the numerical values of the corner function for some pairs of angles are obtained. In the special case of vertices corresponding to explementary angles, we provide numerical evidence that the corner function of the logarithmic negativity is given by the corner function of the R\ue9nyi entropy of order 1/2

Impaired parkin-mediated mitochondrial targeting to autophagosomes differentially contributes to tissue pathology in lysosomal storage diseases

Dysfunctional mitochondria are a well-known disease hallmark. The accumulation of aberrant mitochondria can alter cell homeostasis, thus resulting in tissue degeneration. Lysosomal storage disorders (LSDs) are a group of inherited diseases characterized by the buildup of undegraded material inside the lysosomes that leads to autophagic-lysosomal dysfunction. In LSDs, autophagic stress has been associated to mitochondrial accumulation and dysfunction. However, the mechanisms underlying mitochondrial aberrations and how these are involved in tissue pathogenesis remain largely unexplored. In normal conditions, mitochondrial clearance occurs by mitophagy, a selective form of autophagy, which relies on a parkin-mediated mitochondrial priming and subsequent sequestration by autophagosomes. Here, we performed a detailed analysis of key steps of mitophagy in a mouse model of multiple sulfatase deficiency (MSD), a severe type of LSD characterized by both neurological and systemic involvement. We demonstrated that in MSD liver reduced parkin levels resulted in inefficient mitochondrial priming, thus contributing to the accumulation of giant mitochondria that are located outside autophagic vesicles ultimately leading to cytochrome c release and apoptotic cell death. Morphological and functional changes were also observed in mitochondria from MSD brain but these were not directly associated with neuronal cell loss, suggesting a secondary contribution of mitochondria to neurodegeneration. Together, these data shed new light on the mechanisms underlying mitochondrial dysfunction in LSDs and on their tissue-specific differential contribution to the pathogenesis of this group of metabolic disorders

A contour for the entanglement entropies in harmonic lattices

We construct a contour function for the entanglement entropies in generic harmonic lattices. In one spatial dimension, numerical analysis are performed by considering harmonic chains with either periodic or Dirichlet boundary conditions. In the massless regime and for some configurations where the subsystem is a single interval, the numerical results for the contour function are compared to the inverse of the local weight function which multiplies the energy-momentum tensor in the corresponding entanglement hamiltonian, found through conformal field theory methods, and a good agreement is observed. A numerical analysis of the contour function for the entanglement entropy is performed also in a massless harmonic chain for a subsystem made by two disjoint intervals

Partial transpose of two disjoint blocks in XY spin chains

We consider the partial transpose of the spin reduced density matrix of two disjoint blocks in spin chains admitting a representation in terms of free fermions, such as XY chains. We exploit the solution of the model in terms of Majorana fermions and show that such partial transpose in the spin variables is a linear combination of four Gaussian fermionic operators. This representation allows to explicitly construct and evaluate the integer moments of the partial transpose. We numerically study critical XX and Ising chains and we show that the asymptotic results for large blocks agree with conformal field theory predictions if corrections to the scaling are properly taken into account

Spin structures and entanglement of two disjoint intervals in conformal field theories

We reconsider the moments of the reduced density matrix of two disjoint intervals and of its partial transpose with respect to one interval for critical free fermionic lattice models. It is known that these matrices are sums of either two or four Gaussian matrices and hence their moments can be reconstructed as computable sums of products of Gaussian operators. We find that, in the scaling limit, each term in these sums is in one-to-one correspondence with the partition function of the corresponding conformal field theory on the underlying Riemann surface with a given spin structure. The analytical findings have been checked against numerical results for the Ising chain and for the XX spin chain at the critical point