MOESM1 of Joint model robustness compared with the time-varying covariate Cox model to evaluate the association between a longitudinal marker and a time-to-event endpoint

Additional file 1 Supplementary Appendix

Additional file 1 of Complexity of nursing care at 24 h from admission predicts in-hospital mortality in medical units: a cohort study

Additional file 1: Table S1. Characteristics of the 5129 patients at the first admission. Table S2. Unadjusted and adjusted Cox models (total number of events: 312) on mortality in patients with only one admission. The HR of SIPI (> 50 vs ≤50) was estimated separately within 2 time-intervals: before and after day 10. The effect of SIPI as a continuous variable estimated on a separate multivariable model is also reported

Additional file 1: of Determinants of patient and health care services delays for tuberculosis diagnosis in Italy: a cross-sectional observational study

Table S1. Results from quantile regression on patient-related delay. Table S2 Results from quantile regression on healthcare-related delay. (DOCX 17 kb

Selective Synthesis of a Salt and a Cocrystal of the Ethionamide–Salicylic Acid System

Herein is presented a rare example of salt/cocrystal polymorphism involving the adduct between ethionamide (ETH) and salicylic acid (SAL). Both the salt and cocrystal forms have the same stoichiometry and composition and are both stable at room temperature. The synthetic procedure was successfully optimized in order to selectively obtain both polymorphs. The two adducts’ structures were thoroughly investigated by means of single-crystal X-ray diffraction, solid-state NMR spectroscopy, and density functional theory (DFT) calculations. From the solid-state NMR point of view, the combination of mono- and multinuclear experiments (1H MAS, 13C and 15N CPMAS, 1H-{14N} D-HMQC, 1H–14N PM-S-RESPDOR) provided undoubted spectroscopic evidence about the different positions of the hydrogen atom along the main N···H···O interaction. In particular, the 1H–14N PM-S-RESPDOR allowed N–H distance measurements through the 1H detected signal at a very high spinning speed (70 kHz), which remarkably agree with those derived by DFT optimized X-ray diffraction, even on a natural abundance real system. The thermodynamic relationship between the salt and the cocrystal was inquired from the experimental and computational points of view, enabling the characterization of the two polymorphs as enantiotropically related. The performances of the two forms in terms of dissolution rate are comparable to each other but significantly higher with respect to the pure ETH