22 research outputs found

    Data for: Presidential Party Affiliation and Electoral Cycles in the U.S. Economy: Evidence from Party Changes in Adjacent Terms

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    code and data for Presidential Party Affiliation and Electoral Cycles in the U.S. Economy: Evidence from Party Changes in Adjacent Terms by Joe Stone and Dave Jacob

    Skull measurements_Nov 2014

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    Skull measurements for individuals from ten species of horseshoe bats (Rhinolophidae)

    External measurements_Nov 2014

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    Individual size, bite force and call frequency measurements for ten species of horseshoe bats (Rhinolophidae)

    Bioavailability and Pharmacokinetics of Once-Daily Amantadine Extended-Release Tablets in Healthy Volunteers: Results from 3 Randomized, Crossover, Open-Label, Phase 1 Studies

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    Provide enhanced digital features for this article If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact [email protected]. The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. Other enhanced features include, but are not limited to: • Slide decks • Videos and animations • Audio abstracts • Audio slides</p

    Pathway from built environment to health effects (adapted from Mitchell CS, Hodgson MJ, unpublished data)

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    <p><b>Copyright information:</b></p><p>Taken from "Improving Indoor Environmental Quality for Public Health: Impediments and Policy Recommendations"</p><p></p><p>Environmental Health Perspectives 2007;115(6):953-957.</p><p>Published online 25 Jan 2007</p><p>PMCID:PMC1892115.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI</p

    Pathway from perception of IEQ risk and modifying factors to likelihood of political action adapted from

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    <p><b>Copyright information:</b></p><p>Taken from "Improving Indoor Environmental Quality for Public Health: Impediments and Policy Recommendations"</p><p></p><p>Environmental Health Perspectives 2007;115(6):953-957.</p><p>Published online 25 Jan 2007</p><p>PMCID:PMC1892115.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI</p

    Efficacy and safety of mirogabalin for the treatment of fibromyalgia: results from three 13-week randomized, double-blind, placebo- and active-controlled, parallel-group studies and a 52-week open-label extension study

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    Objective: To investigate the efficacy and safety of mirogabalin, an α2δ ligand, in patients with fibromyalgia (FM). Methods: In three 13-week, multicenter, double-blind, phase 3 studies (studies A, B, and C), patients with FM (n = 1293, 1270, and 1301, respectively) were randomized (1:1:1:1) to placebo, pregabalin 150 mg twice daily, mirogabalin 15 mg once daily or mirogabalin 15 mg twice daily. The primary endpoint was the change in weekly average daily worst pain score (ADPS) at week 13. Key secondary endpoints included Patient Global Impression of Change and change in the Fibromyalgia Impact Questionnaire total score. Long-term safety of mirogabalin was assessed in a 52-week extension study. Results: Neither mirogabalin dose demonstrated a significant ADPS reduction from baseline vs. placebo at week 13 in any of the three studies. Pregabalin significantly reduced ADPS from baseline vs. placebo in studies B and C (p = .0008 and .0001, respectively). The effect of mirogabalin compared with placebo on key secondary endpoints was variable across the studies. Mirogabalin was well tolerated by most patients in the phase 3 studies; no unexpected adverse events occurring during the 52-week extension study. Conclusion: While both mirogabalin doses were well tolerated by most patients and showed potential for reducing pain associated with FM, the primary endpoint of significant pain reduction in patients on mirogabalin compared with placebo was not achieved in any of the three randomized controlled studies. Clinical trial registration: NCT02146430; NCT02187159; NCT02187471; and NCT02234583 (extension study).</p

    Structure and Dynamics of Surfactant Interfaces in Organically Modified Clays

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    Organic modification of clays with surfactants is required for the preparation of polymer-clay nanocomposites for a variety of applications. We have studied the structure and dynamics of interfaces in synthetic clays modified with phosphonium surfactants. The chemical shifts, line widths, and relaxation times measured by 31P, 13C, and 1H NMR and the relaxation times measured by impedance spectroscopy allow us to monitor the dynamics over a wide range of time scales. The results show that the phosphonium headgroup is most restricted and that the mobility increases with increasing separation from the clay surface. The carbon chemical shifts show that the 16-carbon and 12-carbon surfactant tails of hexadecyltributyl phosphonium and dodecytriphenyl phosphonium are disordered at the interface and experience mobility over a range of time scales. The dynamics depend most strongly on the structure of the surfactant headgroup, and tributylphosphoniums are more mobile than the triphenylphosphoniums. Two dimensional chemical shift anisotropy spin exchange experiments show that the phosphorus atoms in the triphenylphosphonium surfactant are immobile on the clay surface on a 1 s time scale. The dynamics measured by impedance spectroscopy show a similar dependence on headgroup structure, even though the processes occur on very different time scales and length scales. The relationship between the structure and dynamics of the interface and the properties of composites are considered
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