Box and whisker plots of three biomarkers of oxidative stress by exposure to environmental tobacco smoke.

<p>Box and whisker plots of three biomarkers of oxidative stress by exposure to environmental tobacco smoke.</p

Univariate and multivariate linear regression analyses of the association between exposure to environmental tobacco smoke and three biomarkers of oxidative stress.

*<p>adjusted for age, sex, SIMD5.</p

Summary characteristics of patients hospitalised for myocardial infarction categorised by exposure to environmental tobacco smoke.

<p>MWU, chi square for trend.</p><p>N number; SIMD5 Scottish Index of Multiple Deprivation quintile; MDA; LDL; IQR interquartile range.</p

Absolute changes in confirmed stroke (cerebral infarction plus intracerebral haemorrhage) incidence referent to pre-legislation slope.

<p>CI confidence interval.</p>*<p>adjusted for sex, age, residence and deprivation quintile.</p

Time trends in stroke incidence (hospital admissions plus pre-hospital deaths).

<p>Footnote: graphs show lowess smoothed incidence rates with a bandwidth of 0.1.</p

Absolute changes in cerebral infarction incidence referent to pre-legislation slope.

<p>CI confidence interval.</p>*<p>adjusted for sex, age, residence and deprivation quintile.</p

Calculated typical error of measurement (TEM) and coefficients of variation (COV).

(a) TEM of tissues and (b) brain regions for all methods investigated. (c) %COV of tissues and (d) brain regions for all methods investigated. G1 = group 1 (automatic blood sampling), G2 = group 2 (manual sampling) and G3 = group 3 (image derived input function).</p

Concentration of [¹⁸F]AB5186 and parent fraction in rat whole blood and plasma.

Normalised measured radioactive concentration in whole blood and plasma using different sampling methods (a) and parent fraction profile in plasma over time following bolus intravenous injection of [18F]AB5186. The insert graph shows the same data between 0–10 minutes. (b). Automatic whole blood and plasma refer to measurements using the automatic blood sampler system. Manual whole blood and plasma refer to measurements using manual sampling of arterial blood. All data has been normalized relative to injected dose, so that the different whole blood and plasma curves can be compared with each other. Data presented as mean±SEM, n = 3.</p

[¹⁸F]AB5186 kinetic modelling results obtained using 2T compartmental model and Logan graphical analysis with various methods used to derive the input function (mean±SEM, n = 3).

[18F]AB5186 kinetic modelling results obtained using 2T compartmental model and Logan graphical analysis with various methods used to derive the input function (mean±SEM, n = 3).</p

Bland-Altman plots assessing agreement between 2T model and Logan graphical analysis in all tissues with different input functions methods.

Group 1 (Logan) and Group 1 (2T) (a); Group 1 (Logan) and Group 2 (Logan) (b); and Group 1 (Logan) and Group 3 (Logan) (c). This was also carried out using only brain regions for Group 1 (Logan) and Group 1 (2T) (d); Group 1 (Logan) and Group 2 (Logan) (e); and Group 1 (Logan) and Group 3 (Logan) (f).</p