Distribution of functional distances (Y-axis in fraction) in bins of 20% sequence identity (X-axis)

<p><b>Copyright information:</b></p><p>Taken from "Quantitative sequence-function relationships in proteins based on gene ontology"</p><p>http://www.biomedcentral.com/1471-2105/8/294</p><p>BMC Bioinformatics 2007;8():294-294.</p><p>Published online 8 Aug 2007</p><p>PMCID:PMC1976327.</p><p></p> The graphs present the distribution of all functions (Similar + Dissimilar)

Distribution of fraction of Dissimilar function (Ordinate: fraction) versus sequence identity (X-axis in bins of 10%)

<p><b>Copyright information:</b></p><p>Taken from "Quantitative sequence-function relationships in proteins based on gene ontology"</p><p>http://www.biomedcentral.com/1471-2105/8/294</p><p>BMC Bioinformatics 2007;8():294-294.</p><p>Published online 8 Aug 2007</p><p>PMCID:PMC1976327.</p><p></p> The top of each box is the upper 75percentile, the bottom is the lower 25percentile. The median of each box is also shown but is superimposed on the 25percentile. The circles are single extreme cases. The line joins the mean fraction of Dissimilar function at each level of sequence identity. The mean is well above the median due to the extreme skewness of the distribution towards mostly similar function

The dependence of function divergence on sequence divergence for the EF-hand family in which the proteins with only the supported annotations were utilized

<p><b>Copyright information:</b></p><p>Taken from "Quantitative sequence-function relationships in proteins based on gene ontology"</p><p>http://www.biomedcentral.com/1471-2105/8/294</p><p>BMC Bioinformatics 2007;8():294-294.</p><p>Published online 8 Aug 2007</p><p>PMCID:PMC1976327.</p><p></p> Abscissa; GO Distance; Ordinate; fraction of comparisons. Different colors show distributions of sets of pairs of proteins with different ranges of sequence similarity, divided into bins of width 10% residue identity