Data_Sheet_1_Conflict Adaptation in 5-Year-Old Preschool Children: Evidence From Emotional Contexts.docx

This research investigated the individual behavioral and electrophysiological differences during emotional conflict adaptation processes in preschool children. Thirty children (16 girls, mean age 5.44 ± 0.28 years) completed an emotional Flanker task (stimulus-stimulus cognitive control, S-S) and an emotional Simon task (stimulus-response cognitive control, S-R). Behaviorally, the 5-year-old preschool children exhibited reliable congruency sequence effects (CSEs) in the emotional contexts, with faster response times (RTs) and lower error rates in the incongruent trials preceded by an incongruent trial (iI trial) than in the incongruent trials preceded by a congruent trial (cI trial). Regarding electrophysiology, the children demonstrated longer N2 and P3 latencies in the incongruent trials than in the congruent trials during emotional conflict control processes. Importantly, the boys showed a reliable CSE of N2 amplitude when faced with fearful target expression. Moreover, 5-year-old children showed better emotional CSEs in response to happy targets than to fearful targets as demonstrated by the magnitude of CSEs in terms of the RT, error rate, N2 amplitude and P3 latency. In addition, the results demonstrated that 5-year-old children processed S-S emotional conflicts and S-R emotional conflicts differently and performed better on S-S emotional conflicts than on S-R emotional conflicts according to the comparison of the RT-CSE and P3 latency-CSE values. The current study provides insight into how emotionally salient stimuli affect cognitive processes among preschool children.</p

Data_Sheet_2_Conflict Adaptation in 5-Year-Old Preschool Children: Evidence From Emotional Contexts.xlsx

This research investigated the individual behavioral and electrophysiological differences during emotional conflict adaptation processes in preschool children. Thirty children (16 girls, mean age 5.44 ± 0.28 years) completed an emotional Flanker task (stimulus-stimulus cognitive control, S-S) and an emotional Simon task (stimulus-response cognitive control, S-R). Behaviorally, the 5-year-old preschool children exhibited reliable congruency sequence effects (CSEs) in the emotional contexts, with faster response times (RTs) and lower error rates in the incongruent trials preceded by an incongruent trial (iI trial) than in the incongruent trials preceded by a congruent trial (cI trial). Regarding electrophysiology, the children demonstrated longer N2 and P3 latencies in the incongruent trials than in the congruent trials during emotional conflict control processes. Importantly, the boys showed a reliable CSE of N2 amplitude when faced with fearful target expression. Moreover, 5-year-old children showed better emotional CSEs in response to happy targets than to fearful targets as demonstrated by the magnitude of CSEs in terms of the RT, error rate, N2 amplitude and P3 latency. In addition, the results demonstrated that 5-year-old children processed S-S emotional conflicts and S-R emotional conflicts differently and performed better on S-S emotional conflicts than on S-R emotional conflicts according to the comparison of the RT-CSE and P3 latency-CSE values. The current study provides insight into how emotionally salient stimuli affect cognitive processes among preschool children.</p

Additional file 1 of Spontaneous regression of an isolated retinal astrocytic hamartoma in a newborn: a case report

Supplementary Material

<i></i>β-Diketiminato Rare-Earth Metal Complexes. Structures, Catalysis, and Active Species for Highly <i>cis</i>-1,4-Selective Polymerization of Isoprene

Lithiation of the β-diketimines (2,6-C6H3R2)NHC(Me)CHC(Me)N(2,6-C6H3R2) (R = Me (HL1), Et (HL2)) by nBuLi was followed by metathesis reaction with LnCl3(THF)x and Y(BH4)3(THF)2 to afford the corresponding complexes L1LnCl2(THF)2 (Ln = Gd (1), Nd (3), Dy (4), Er (5), Y (6)), L2GdCl2(THF)2 (2), and L1Y(BH4)2(THF) (8), respectively. Treatment of neutral HL1 with Y(CH2SiMe3)3(THF)2 generated the bis(alkyl) complex 7, L1Y(CH2SiMe3)2(THF). Upon activation with [PhNHMe2][B(C6F5)4] and AliBu3, complex 6 showed the highest cis-1,4 selectivity (99.3%, Tp = 0 °C) toward the polymerization of isoprene, while complex 7 had a comparatively low cis-1,4 selectivity, and in contrast, complex 8 was completely inert. The influences of the ortho substituents of the N-aryl rings of the ligands, the types of central metals and cocatalysts, and addition sequence of the catalyst components had been thoroughly investigated. By means of X-ray diffraction and 1H NMR spectroscopy analyses, the intermediates arising from the stoichiometric reactions among the catalyst components and the probable active species were elucidated, which facilitates further investigation of the mechanism for diene polymerization

Highly 3,4-Selective Polymerization of Isoprene with NPN Ligand Stabilized Rare-Earth Metal Bis(alkyl)s. Structures and Performances

Deprotonation of Ar1NHPPh2NAr2 (H[NPN]n, n = 1−10) by Ln(CH2SiMe3)3(THF)2 (Ln = Lu, Y, Sc, Er) generated a series of rare-earth metal bis(alkyl) complexes [NPN]nLn(CH2SiMe3)2(THF)2 (1−10), which under activation with [Ph3C][B(C6F5)4] and AliBu3 were tested for isoprene polymerization. The correlation between catalytic performances and molecular structures of the complexes has been investigated. Complexes 1−5 and 8, where Ar1 is nonsubstituted or ortho-alkyl-substituted phenyl, adopt trigonal-bipyramidal geometry. The Ar1 and Ar2 rings are perpendicular in 1−4 and 8 but parallel in 5. When Ar1 is pyridyl, the resultant lutetium and yttrium complexes 9a and 9b adopt tetragonal geometry with the ligand coordinating to the metal ions in a N,N,N-tridentate mode, whereas in the scandium analogue 9c, the ligand coordinates to the Sc3+ ion in a N,N-bidentate mode. These structural characteristics endow the complexes with versatile catalytic performances. With increase of the steric bulkiness of the ortho-substituents Ar1 and Ar2, the 3,4-selectivity increased stepwise from 81.6% for lutetium complex 1 to 96.8% for lutetium complex 6 and to 97.8% for lutetium complex 7a. However, further increase of the steric bulk of the ligand led to a slight drop of 3,4-selectivity for the attached complex 5 (95.1%). When the smaller scandium ion was employed, the corresponding complex 7c provided 98.1% 3,4-selectivity, which reached 99.4% when the polymerization was performed at −20 °C, and the polymerization had quasi-living characteristics. Complexes 9a and 9b, containing an electron-donating ligand, gave higher 3,4-selectivities (85.0% vs 85.5%) than those attached to electron-withdrawing ligands 9c (33%) and 10 (77%)

<i></i>β-Diketiminato Rare-Earth Metal Complexes. Structures, Catalysis, and Active Species for Highly <i>cis</i>-1,4-Selective Polymerization of Isoprene

Lithiation of the β-diketimines (2,6-C6H3R2)NHC(Me)CHC(Me)N(2,6-C6H3R2) (R = Me (HL1), Et (HL2)) by nBuLi was followed by metathesis reaction with LnCl3(THF)x and Y(BH4)3(THF)2 to afford the corresponding complexes L1LnCl2(THF)2 (Ln = Gd (1), Nd (3), Dy (4), Er (5), Y (6)), L2GdCl2(THF)2 (2), and L1Y(BH4)2(THF) (8), respectively. Treatment of neutral HL1 with Y(CH2SiMe3)3(THF)2 generated the bis(alkyl) complex 7, L1Y(CH2SiMe3)2(THF). Upon activation with [PhNHMe2][B(C6F5)4] and AliBu3, complex 6 showed the highest cis-1,4 selectivity (99.3%, Tp = 0 °C) toward the polymerization of isoprene, while complex 7 had a comparatively low cis-1,4 selectivity, and in contrast, complex 8 was completely inert. The influences of the ortho substituents of the N-aryl rings of the ligands, the types of central metals and cocatalysts, and addition sequence of the catalyst components had been thoroughly investigated. By means of X-ray diffraction and 1H NMR spectroscopy analyses, the intermediates arising from the stoichiometric reactions among the catalyst components and the probable active species were elucidated, which facilitates further investigation of the mechanism for diene polymerization

Highly 3,4-Selective Polymerization of Isoprene with NPN Ligand Stabilized Rare-Earth Metal Bis(alkyl)s. Structures and Performances

Deprotonation of Ar1NHPPh2NAr2 (H[NPN]n, n = 1−10) by Ln(CH2SiMe3)3(THF)2 (Ln = Lu, Y, Sc, Er) generated a series of rare-earth metal bis(alkyl) complexes [NPN]nLn(CH2SiMe3)2(THF)2 (1−10), which under activation with [Ph3C][B(C6F5)4] and AliBu3 were tested for isoprene polymerization. The correlation between catalytic performances and molecular structures of the complexes has been investigated. Complexes 1−5 and 8, where Ar1 is nonsubstituted or ortho-alkyl-substituted phenyl, adopt trigonal-bipyramidal geometry. The Ar1 and Ar2 rings are perpendicular in 1−4 and 8 but parallel in 5. When Ar1 is pyridyl, the resultant lutetium and yttrium complexes 9a and 9b adopt tetragonal geometry with the ligand coordinating to the metal ions in a N,N,N-tridentate mode, whereas in the scandium analogue 9c, the ligand coordinates to the Sc3+ ion in a N,N-bidentate mode. These structural characteristics endow the complexes with versatile catalytic performances. With increase of the steric bulkiness of the ortho-substituents Ar1 and Ar2, the 3,4-selectivity increased stepwise from 81.6% for lutetium complex 1 to 96.8% for lutetium complex 6 and to 97.8% for lutetium complex 7a. However, further increase of the steric bulk of the ligand led to a slight drop of 3,4-selectivity for the attached complex 5 (95.1%). When the smaller scandium ion was employed, the corresponding complex 7c provided 98.1% 3,4-selectivity, which reached 99.4% when the polymerization was performed at −20 °C, and the polymerization had quasi-living characteristics. Complexes 9a and 9b, containing an electron-donating ligand, gave higher 3,4-selectivities (85.0% vs 85.5%) than those attached to electron-withdrawing ligands 9c (33%) and 10 (77%)

Table2_Identification and Validation of EMT-Related lncRNA Prognostic Signature for Colorectal Cancer.XLSX

Background: This study aimed to explore the biological functions and prognostic role of Epithelial-mesenchymal transition (Epithelial-mesenchymal transition)-related lncRNAs in colorectal cancer (CRC).Methods: The Cancer Genome Atlas database was applied to retrieve gene expression data and clinical information. An EMT-related lncRNA risk signature was constructed relying on univariate Cox regression, Least Absolute Shrinkage and Selector Operation (LASSO) and multivariate Cox regression analysis of the EMT-related lncRNA expression data and clinical information. Then, an individualized prognostic prediction model based on the nomogram was developed and the predictive accuracy and discriminative ability of the nomogram were determined by the receiver operating characteristic curve and calibration curve. Finally, a series of analyses, such as functional analysis and unsupervised cluster analysis, were conducted to explore the influence of independent lncRNAs on CRC.Results: A total of 581 patients were enrolled and an eleven-EMT-related lncRNA risk signature was identified relying on the comprehensive analysis of the EMT-related lncRNA expression data and clinical information in the training cohort. Then, risk scores were calculated to divide patients into high and low-risk groups, and the Kaplan-Meier curve analysis showed that low-risk patients tended to have better overall survival (OS). Multivariate Cox regression analysis indicated that the EMT-related lncRNA signature was significantly associated with prognosis. The results were subsequently confirmed in the validation dataset. Then, we constructed and validated a predictive nomogram for overall survival based on the clinical factors and risk signature. Functional characterization confirmed this signature could predict immune-related phenotype and was associated with immune cell infiltration (i.e., macrophages M0, M1, Tregs, CD4 memory resting cells, and neutrophils), tumor mutation burden (TMB).Conclusions: Our study highlighted the value of the 11-EMT-lncRNA signature as a predictor of prognosis and immunotherapeutic response in CRC.</p

DataSheet1_Identification and Validation of EMT-Related lncRNA Prognostic Signature for Colorectal Cancer.PDF

Background: This study aimed to explore the biological functions and prognostic role of Epithelial-mesenchymal transition (Epithelial-mesenchymal transition)-related lncRNAs in colorectal cancer (CRC).Methods: The Cancer Genome Atlas database was applied to retrieve gene expression data and clinical information. An EMT-related lncRNA risk signature was constructed relying on univariate Cox regression, Least Absolute Shrinkage and Selector Operation (LASSO) and multivariate Cox regression analysis of the EMT-related lncRNA expression data and clinical information. Then, an individualized prognostic prediction model based on the nomogram was developed and the predictive accuracy and discriminative ability of the nomogram were determined by the receiver operating characteristic curve and calibration curve. Finally, a series of analyses, such as functional analysis and unsupervised cluster analysis, were conducted to explore the influence of independent lncRNAs on CRC.Results: A total of 581 patients were enrolled and an eleven-EMT-related lncRNA risk signature was identified relying on the comprehensive analysis of the EMT-related lncRNA expression data and clinical information in the training cohort. Then, risk scores were calculated to divide patients into high and low-risk groups, and the Kaplan-Meier curve analysis showed that low-risk patients tended to have better overall survival (OS). Multivariate Cox regression analysis indicated that the EMT-related lncRNA signature was significantly associated with prognosis. The results were subsequently confirmed in the validation dataset. Then, we constructed and validated a predictive nomogram for overall survival based on the clinical factors and risk signature. Functional characterization confirmed this signature could predict immune-related phenotype and was associated with immune cell infiltration (i.e., macrophages M0, M1, Tregs, CD4 memory resting cells, and neutrophils), tumor mutation burden (TMB).Conclusions: Our study highlighted the value of the 11-EMT-lncRNA signature as a predictor of prognosis and immunotherapeutic response in CRC.</p

sj-docx-1-tct-10.1177_15330338211064438 - Supplemental material for Up-frameshift Protein 1 Promotes Tumor Progression by Regulating Apoptosis and Epithelial–Mesenchymal Transition of Colorectal Cancer

Supplemental material, sj-docx-1-tct-10.1177_15330338211064438 for Up-frameshift Protein 1 Promotes Tumor Progression by Regulating Apoptosis and Epithelial–Mesenchymal Transition of Colorectal Cancer by Binlie Chen, Huaiming Wang, Danfeng Li, Xiaosheng Lin, Zhiyan Ma and Yongming Zeng in Technology in Cancer Research & Treatment</p