Data_Sheet_1_Association between mobile phone addiction and social support among mainland Chinese teenagers: A meta-analysis.PDF

BackgroundMobile phone addiction brings many adverse effects to teenagers, such as physical health problems, emotional problems, and academic failure, and studies have found that social support is an important influencing factor. Therefore, considering institutional, cultural and economic differences, we aimed to investigate the association between mobile phone addiction and social support among mainland Chinese teenagers, and explored the moderators affecting the relation.MethodsBased on the PRISMA method, a meta-analysis was applied to quantitatively synthesize relevant findings to obtain reliable estimates of effect sizes and conduct moderator analyses.ResultsIn total, 92 studies involving 59,716 participants and 92 effect sizes were identified by a systematic literature search. A significant low degree of negative correlation was found between mobile phone addiction and social support (r = −0.174, 95%CI = −0.213 to −0.134, p 2 = 96.1%). Moreover, the present meta-analysis observed significant moderating effects of participants' gender, and region on the association between social support and mobile phone addiction.ConclusionThis study suggests that the mobile phone addiction level of teenagers could be reduced by increasing social support, and actions to improve their social support levels should be proposed based on their gender and regional differences.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021276672.</p

Additional file 1: Table S1. of Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study

Correlations between pathology variables. (DOC 45 kb

Primer sequences for real-time quantitative PCR.

<p>Primer sequences for real-time quantitative PCR.</p

Y20 attenuates cardiac fibrosis in the hearts of HFD-fed rats.

<p>(A) Representative images for Sirius Red staining and masson staining in the formalin-fixed myocardial tissues indicating collagen deposition and implying the extent of cardiac fibrosis (400×magnification). (B) Western blot analysis for the protein expression of TGF-β in the myocardial tissues was performed. (C-F) The mRNA expression of fibrotic markers such as collagen 1, TGF-β, MMP-2 and MMP-9 in the myocardial tissues was detected by real-time qPCR. Four rats in each group were used for above analysis. * <i>P</i><0.05, ** <i>P</i><0.01 v.s. HFD group; # <i>P</i><0.05 v.s. vehicle control (Ctrl).</p

Additional file 1 of Artificial intelligence assists identification and pathologic classification of glomerular lesions in patients with diabetic nephropathy

Additional file 1. Supplementary Materia

Y20 mitigates HFD-induced cardiac apoptosis in HFD-fed rats.

<p>(A) Representative images and statistic figure for TUNEL staining in heart tissues sections. (B) Western Blot analysis for the protein expression of apoptosis-related proteins in myocardial tissues was performed. Four to six rats in each group were used for above analysis. * <i>P</i><0.05, ** <i>P</i><0.01 v.s. HFD group; # <i>P</i><0.05 v.s. vehicle control (Ctrl).</p

The design and synthesis of compound Y20.

<p>(A) The chemical structure of curcumin, C66 and Y20. (B) The chemical synthesis of Y20. Reagents and conditions: (i) 4-Methylbenzenesulfonic acid, toluene, 110℃ reflux, 4h; (ii) EtOH, 78℃, reflux, 5h, saturate HCl; (iii) 20% NaOH, EtOH, r.t., 10h.</p

Y20 attenuates cardiac histological abnormalities and hypertrophy in the hearts of HFD-fed rats.

<p>(A) Representative images for the Hematoxylin-Eosin (H&E) staining in the formalin-fixed myocardial tissues (400× magnification). (B) Qantitative data of myocyte cross-section lenth of 100 cells chosen from different visual scopes of 4 samples per group in myocardial transverse H&E staining were shown. (C) Western blot analysis for the protein expression of ANP in the myocardial tissues was performed. (D & E) The mRNA expression of the hypertrophic markers ANP and BNP in the myocardial tissues was detected by real-time qPCR. Four rats in each group were used for above analysis. *, <i>P</i><0.05, **, <i>P</i><0.01 v.s. HFD; # <i>P</i><0.05 v.s. vehicle control (Ctrl).</p

Advancing the application of the analytical renal pathology system in allograft IgA nephropathy patients

The analytical renal pathology system (ARPS) based on convolutional neural networks has been used successfully in native IgA nephropathy (IgAN) patients. Considering the similarity of pathologic features, we aim to evaluate the performance of the ARPS in allograft IgAN patients and broaden its implementation. Biopsy-proven allograft IgAN patients from two different centers were enrolled for internal and external validation. We implemented the ARPS to identify glomerular lesions and intrinsic glomerular cells, and then evaluated its performance. Consistency between the ARPS and pathologists was assessed using intraclass correlation coefficients. The association of digital pathological features with clinical and pathological data was measured. Kaplan-Meier survival curve and cox proportional hazards model were applied to investigate prognosis prediction. A total of 56 biopsy-proven allograft IgAN patients from the internal center and 17 biopsy-proven allograft IgAN patients from the external center were enrolled in this study. The ARPS was successfully applied to identify the glomerular lesions (F1-score, 0.696–0.959) and quantify intrinsic glomerular cells (F1-score, 0.888–0.968) in allograft IgAN patients rapidly and precisely. Furthermore, the mesangial hypercellularity score was positively correlated with all mesangial metrics provided by ARPS [Spearman’s correlation coefficient (r), 0.439–0.472, and all p values We propose that the ARPS could be implemented in future clinical practice with outstanding capability.</p

miR-10a reduces proliferation of hCMPCs.

<p>A. miR-10a mimics decrease the BrdU incorporation rate of hCMPCs, whereas a miR-10a inhibitor does not significantly affect the process. *P<0.05, n = 6. B. miR-10a inhibits EdU incorporation of hCMPCs. Representative image of hCMPCs transfected with mock, miR-10a mimics or inhibitor stained with DAPI (blue) and EdU (red) (×200). *P<0.05, n = 5. C. Representative flow cytometry results of hCMPC manipulated with mock, miR-10a mimics or miR-10a inhibitor. hCMPCs overexpressing miR-10a show G1/S blocking, and the inhibition of miR-10a promotes G1/S transition compare with mock. D. Data collected from C. *P<0.05, n = 3. E. Relative expression of cell cycle regulatory genes in hCMPCs transfected with miR-10a mimics. F. The same set of genes was measured in hCMPCs with inhibited miR-10a. The expression level of GAPDH was used as the control. *P<0.05, n = 5.</p