29 research outputs found

    An Isoflavone from <i>Leiophyllum buxifolium</i> and Its Antiproliferative Effect

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    A new <i>C-</i>methylisoflavone, isosideroxylin (<b>1</b>), and a known <i>C</i>-methylflavone, sideroxylin (<b>2</b>), were isolated from the EtOAc extract of the leaves of <i>Leiophyllum buxifolium.</i> The two compounds were evaluated with the sulforhodamine B assay for their antiproliferative effects against ER<sup>ā€“</sup> MDA-MB-231 and ER<sup>+</sup> MCF-7 breast cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin (<b>1</b>) displayed a selective antiproliferative effect against MDA-MB-231 cells

    Levels of TNF-Ī± in muscles and plasma of mice.

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    <p>Following 24 weeks of high fat diet treatment, mice received repeated acid saline injections into the gastrocnemius muscle. Samples of plasma and gastrocnemius muscles were collected. The concentrations of TNF-Ī± in (<b>A</b>) muscles and (<b>B</b>) plasma were determined by ELISA. The limit of detection for TNF-Ī± was 0.1 pg/mL. *represent the significant difference (p<0.05) to saline control mice. <sup><i>#</i></sup>represent the significant difference (p<0.05) to low fat diet mice. N = 8/group.</p

    Effects of high fat diet treatment on acid saline injection-induced mechanical hypersensitivity in female TNFRp55-/- mice.

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    <p>Following 24 weeks of high fat diet treatment, mice received repeated acid saline injections into the gastrocnemius muscle. Mechanical withdrawal thresholds were then measure using an electronic von Frey device for 4 consecutive days. Data are presented as mean Ā± SEM. N = 8/group.</p

    Levels of TNF-Ī± in spinal cord and DRG.

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    <p>Mice were sacrificed after the last behavioral test, and samples of spinal cord and L3-L5 DRG tissues were collected in separate groups of mice. The concentrations of TNF-Ī± in spinal cord were determined by ELISA. L3-L5 DRG tissues were sectioned to a thickness of 15Ī¼m and underwent immunofluorescent staining. The images were quantitatively analyzed by NIH ImageJ. <i>*</i>represent the significant difference (p<0.05) to saline control mice. <sup><i>#</i></sup>represents the significant difference (p<0.05) to low fat diet mice. N = 8/group.</p

    Effects of high fat diet treatment on acid saline injection-induced mechanical hypersensitivity.

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    <p>Following 24 weeks of high fat diet treatment, mice received repeated acid saline injections into the gastrocnemius muscle. Mechanical withdrawal thresholds were then measured using an electronic von Frey device for 4 consecutive days. Data are presented as mean Ā± SEM. Bonferroni correction for multiple comparisons. <i>*</i>represent the significant difference (p<0.05) to saline control mice. <sup><i>#</i></sup>represent the significant difference (p<0.05) to low fat diet mice. N = 8/group.</p

    Temperature-Dependent Structures of Lanthanide Metalā€“Organic Frameworks Based on Furan-2,5-Dicarboxylate and Oxalate

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    Two series of lanthanide metalā€“organic frameworks, [LnĀ­(FDA)Ā­(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>1Ln</b>) (Ln = Pr <b>1</b>, Nd <b>2</b>, Eu <b>3</b>, Gd <b>4,</b> Tb <b>5</b>), [LnĀ­(FDA)Ā­(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>2Ln</b>) (Ln = Sm <b>6</b>, Tb <b>7</b>, Dy <b>8</b>, Ho <b>9</b>, Yb <b>10</b>) (OX = oxalate), have been prepared by reacting LnĀ­(NO<sub>3</sub>)<sub>3</sub>Ā·6H<sub>2</sub>O with furan-2,5-dicarboxylic acid (H<sub>2</sub>FDA) at different temperatures under hydrothermal conditions. All the complexes are characterized by elemental analysis, IR, X-ray powder diffraction, and single-crystal X-ray diffraction. Structure analyses show that <b>1Ln</b> and <b>2Ln</b> are supramolecular isomerisms. <b>1Ln</b> possesses a three-dimensional network with monoclinic space group <i>P</i>2<sub>1</sub>/<i>c</i>, whereas <b>2Ln</b> exhibits a three-dimensional framework with monoclinic space group <i>C</i>2/<i>c</i>. The distinct architectures of these two series of ten complexes indicated that the reaction temperature plays an important role in the formation of such coordination structures. Meanwhile, the photoluminescent properties of <b>4</b>, <b>5</b>, <b>7</b>, and <b>8</b> are also investigated in the solid state at room temperature

    Temperature-Dependent Structures of Lanthanide Metalā€“Organic Frameworks Based on Furan-2,5-Dicarboxylate and Oxalate

    No full text
    Two series of lanthanide metalā€“organic frameworks, [LnĀ­(FDA)Ā­(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>1Ln</b>) (Ln = Pr <b>1</b>, Nd <b>2</b>, Eu <b>3</b>, Gd <b>4,</b> Tb <b>5</b>), [LnĀ­(FDA)Ā­(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>2Ln</b>) (Ln = Sm <b>6</b>, Tb <b>7</b>, Dy <b>8</b>, Ho <b>9</b>, Yb <b>10</b>) (OX = oxalate), have been prepared by reacting LnĀ­(NO<sub>3</sub>)<sub>3</sub>Ā·6H<sub>2</sub>O with furan-2,5-dicarboxylic acid (H<sub>2</sub>FDA) at different temperatures under hydrothermal conditions. All the complexes are characterized by elemental analysis, IR, X-ray powder diffraction, and single-crystal X-ray diffraction. Structure analyses show that <b>1Ln</b> and <b>2Ln</b> are supramolecular isomerisms. <b>1Ln</b> possesses a three-dimensional network with monoclinic space group <i>P</i>2<sub>1</sub>/<i>c</i>, whereas <b>2Ln</b> exhibits a three-dimensional framework with monoclinic space group <i>C</i>2/<i>c</i>. The distinct architectures of these two series of ten complexes indicated that the reaction temperature plays an important role in the formation of such coordination structures. Meanwhile, the photoluminescent properties of <b>4</b>, <b>5</b>, <b>7</b>, and <b>8</b> are also investigated in the solid state at room temperature

    Temperature-Dependent Structures of Lanthanide Metalā€“Organic Frameworks Based on Furan-2,5-Dicarboxylate and Oxalate

    No full text
    Two series of lanthanide metalā€“organic frameworks, [LnĀ­(FDA)Ā­(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>1Ln</b>) (Ln = Pr <b>1</b>, Nd <b>2</b>, Eu <b>3</b>, Gd <b>4,</b> Tb <b>5</b>), [LnĀ­(FDA)Ā­(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>2Ln</b>) (Ln = Sm <b>6</b>, Tb <b>7</b>, Dy <b>8</b>, Ho <b>9</b>, Yb <b>10</b>) (OX = oxalate), have been prepared by reacting LnĀ­(NO<sub>3</sub>)<sub>3</sub>Ā·6H<sub>2</sub>O with furan-2,5-dicarboxylic acid (H<sub>2</sub>FDA) at different temperatures under hydrothermal conditions. All the complexes are characterized by elemental analysis, IR, X-ray powder diffraction, and single-crystal X-ray diffraction. Structure analyses show that <b>1Ln</b> and <b>2Ln</b> are supramolecular isomerisms. <b>1Ln</b> possesses a three-dimensional network with monoclinic space group <i>P</i>2<sub>1</sub>/<i>c</i>, whereas <b>2Ln</b> exhibits a three-dimensional framework with monoclinic space group <i>C</i>2/<i>c</i>. The distinct architectures of these two series of ten complexes indicated that the reaction temperature plays an important role in the formation of such coordination structures. Meanwhile, the photoluminescent properties of <b>4</b>, <b>5</b>, <b>7</b>, and <b>8</b> are also investigated in the solid state at room temperature

    A Water-Stable Metalā€“Organic Framework for Highly Sensitive and Selective Sensing of Fe<sup>3+</sup> Ion

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    A new metalā€“organic framework [Zn<sub>5</sub>(hfipbb)<sub>4</sub>(trz)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] (<b>NNU-1</b>) [H<sub>2</sub>hfipbb = 4,4ā€²-(hexafluoroisopropylidene)Ā­bisĀ­(benzoic acid), Htrz = 1<i>H</i>-1,2,3-triazole] was assembled by hydrothermal synthesis. Single-crystal X-ray diffraction analysis reveals that <b>NNU-1</b> displays a twofold interpenetrating three-dimensional (3D) framework with a {4<sup>24</sup>Ā·6<sup>4</sup>}-<b>bcu</b> topology. Interestingly, the 3D framework contains a two-dimensional (2D) layered structure that consists of alternating left- and right-handed double helical chains. On the basis of the hydrophobic āˆ’CF<sub>3</sub> groups from H<sub>2</sub>hfipbb ligand, <b>NNU-1</b> possesses excellent stability in water. It is worth noting that <b>NNU-1</b> not only shows a highly selective fluorescence quenching effect to Fe<sup>3+</sup> ion in aqueous solution but also resists the interference of other metals including Fe<sup>2+</sup> ion. Accordingly, <b>NNU-1</b> probably functions as a potential promising fluorescence sensor for detecting Fe<sup>3+</sup> ion with high sensitivity and selectivity
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