29 research outputs found
An Isoflavone from <i>Leiophyllum buxifolium</i> and Its Antiproliferative Effect
A new <i>C-</i>methylisoflavone,
isosideroxylin (<b>1</b>), and a known <i>C</i>-methylflavone,
sideroxylin
(<b>2</b>), were isolated from the EtOAc extract of the leaves
of <i>Leiophyllum buxifolium.</i> The two compounds were
evaluated with the sulforhodamine B assay for their antiproliferative
effects against ER<sup>ā</sup> MDA-MB-231 and ER<sup>+</sup> MCF-7 breast cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin
(<b>1</b>) displayed a selective antiproliferative effect against
MDA-MB-231 cells
Body weights, one-day food intake amounts, and blood glucose concentrations.
<p>Body weights, one-day food intake amounts, and blood glucose concentrations.</p
Levels of TNF-Ī± in muscles and plasma of mice.
<p>Following 24 weeks of high fat diet treatment, mice received repeated acid saline injections into the gastrocnemius muscle. Samples of plasma and gastrocnemius muscles were collected. The concentrations of TNF-Ī± in (<b>A</b>) muscles and (<b>B</b>) plasma were determined by ELISA. The limit of detection for TNF-Ī± was 0.1 pg/mL. *represent the significant difference (p<0.05) to saline control mice. <sup><i>#</i></sup>represent the significant difference (p<0.05) to low fat diet mice. N = 8/group.</p
Effects of high fat diet treatment on acid saline injection-induced mechanical hypersensitivity in female TNFRp55-/- mice.
<p>Following 24 weeks of high fat diet treatment, mice received repeated acid saline injections into the gastrocnemius muscle. Mechanical withdrawal thresholds were then measure using an electronic von Frey device for 4 consecutive days. Data are presented as mean Ā± SEM. N = 8/group.</p
Levels of TNF-Ī± in spinal cord and DRG.
<p>Mice were sacrificed after the last behavioral test, and samples of spinal cord and L3-L5 DRG tissues were collected in separate groups of mice. The concentrations of TNF-Ī± in spinal cord were determined by ELISA. L3-L5 DRG tissues were sectioned to a thickness of 15Ī¼m and underwent immunofluorescent staining. The images were quantitatively analyzed by NIH ImageJ. <i>*</i>represent the significant difference (p<0.05) to saline control mice. <sup><i>#</i></sup>represents the significant difference (p<0.05) to low fat diet mice. N = 8/group.</p
Effects of high fat diet treatment on acid saline injection-induced mechanical hypersensitivity.
<p>Following 24 weeks of high fat diet treatment, mice received repeated acid saline injections into the gastrocnemius muscle. Mechanical withdrawal thresholds were then measured using an electronic von Frey device for 4 consecutive days. Data are presented as mean Ā± SEM. Bonferroni correction for multiple comparisons. <i>*</i>represent the significant difference (p<0.05) to saline control mice. <sup><i>#</i></sup>represent the significant difference (p<0.05) to low fat diet mice. N = 8/group.</p
Temperature-Dependent Structures of Lanthanide MetalāOrganic Frameworks Based on Furan-2,5-Dicarboxylate and Oxalate
Two series of lanthanide metalāorganic frameworks,
[LnĀ(FDA)Ā(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>1Ln</b>) (Ln = Pr <b>1</b>, Nd <b>2</b>, Eu <b>3</b>, Gd <b>4,</b> Tb <b>5</b>), [LnĀ(FDA)Ā(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>2Ln</b>) (Ln = Sm <b>6</b>, Tb <b>7</b>, Dy <b>8</b>, Ho <b>9</b>, Yb <b>10</b>) (OX = oxalate),
have been prepared by reacting LnĀ(NO<sub>3</sub>)<sub>3</sub>Ā·6H<sub>2</sub>O with furan-2,5-dicarboxylic acid (H<sub>2</sub>FDA) at different
temperatures under hydrothermal conditions. All the complexes are
characterized by elemental analysis, IR, X-ray powder diffraction,
and single-crystal X-ray diffraction. Structure analyses show that <b>1Ln</b> and <b>2Ln</b> are supramolecular isomerisms. <b>1Ln</b> possesses a three-dimensional network with monoclinic
space group <i>P</i>2<sub>1</sub>/<i>c</i>, whereas <b>2Ln</b> exhibits a three-dimensional framework with monoclinic
space group <i>C</i>2/<i>c</i>. The distinct architectures
of these two series of ten complexes indicated that the reaction temperature
plays an important role in the formation of such coordination structures.
Meanwhile, the photoluminescent properties of <b>4</b>, <b>5</b>, <b>7</b>, and <b>8</b> are also investigated
in the solid state at room temperature
Temperature-Dependent Structures of Lanthanide MetalāOrganic Frameworks Based on Furan-2,5-Dicarboxylate and Oxalate
Two series of lanthanide metalāorganic frameworks,
[LnĀ(FDA)Ā(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>1Ln</b>) (Ln = Pr <b>1</b>, Nd <b>2</b>, Eu <b>3</b>, Gd <b>4,</b> Tb <b>5</b>), [LnĀ(FDA)Ā(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>2Ln</b>) (Ln = Sm <b>6</b>, Tb <b>7</b>, Dy <b>8</b>, Ho <b>9</b>, Yb <b>10</b>) (OX = oxalate),
have been prepared by reacting LnĀ(NO<sub>3</sub>)<sub>3</sub>Ā·6H<sub>2</sub>O with furan-2,5-dicarboxylic acid (H<sub>2</sub>FDA) at different
temperatures under hydrothermal conditions. All the complexes are
characterized by elemental analysis, IR, X-ray powder diffraction,
and single-crystal X-ray diffraction. Structure analyses show that <b>1Ln</b> and <b>2Ln</b> are supramolecular isomerisms. <b>1Ln</b> possesses a three-dimensional network with monoclinic
space group <i>P</i>2<sub>1</sub>/<i>c</i>, whereas <b>2Ln</b> exhibits a three-dimensional framework with monoclinic
space group <i>C</i>2/<i>c</i>. The distinct architectures
of these two series of ten complexes indicated that the reaction temperature
plays an important role in the formation of such coordination structures.
Meanwhile, the photoluminescent properties of <b>4</b>, <b>5</b>, <b>7</b>, and <b>8</b> are also investigated
in the solid state at room temperature
Temperature-Dependent Structures of Lanthanide MetalāOrganic Frameworks Based on Furan-2,5-Dicarboxylate and Oxalate
Two series of lanthanide metalāorganic frameworks,
[LnĀ(FDA)Ā(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>1Ln</b>) (Ln = Pr <b>1</b>, Nd <b>2</b>, Eu <b>3</b>, Gd <b>4,</b> Tb <b>5</b>), [LnĀ(FDA)Ā(OX)<sub>0.5</sub>(H<sub>2</sub>O)<sub>2</sub>]Ā·(H<sub>2</sub>O) (<b>2Ln</b>) (Ln = Sm <b>6</b>, Tb <b>7</b>, Dy <b>8</b>, Ho <b>9</b>, Yb <b>10</b>) (OX = oxalate),
have been prepared by reacting LnĀ(NO<sub>3</sub>)<sub>3</sub>Ā·6H<sub>2</sub>O with furan-2,5-dicarboxylic acid (H<sub>2</sub>FDA) at different
temperatures under hydrothermal conditions. All the complexes are
characterized by elemental analysis, IR, X-ray powder diffraction,
and single-crystal X-ray diffraction. Structure analyses show that <b>1Ln</b> and <b>2Ln</b> are supramolecular isomerisms. <b>1Ln</b> possesses a three-dimensional network with monoclinic
space group <i>P</i>2<sub>1</sub>/<i>c</i>, whereas <b>2Ln</b> exhibits a three-dimensional framework with monoclinic
space group <i>C</i>2/<i>c</i>. The distinct architectures
of these two series of ten complexes indicated that the reaction temperature
plays an important role in the formation of such coordination structures.
Meanwhile, the photoluminescent properties of <b>4</b>, <b>5</b>, <b>7</b>, and <b>8</b> are also investigated
in the solid state at room temperature
A Water-Stable MetalāOrganic Framework for Highly Sensitive and Selective Sensing of Fe<sup>3+</sup> Ion
A new
metalāorganic framework [Zn<sub>5</sub>(hfipbb)<sub>4</sub>(trz)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>] (<b>NNU-1</b>) [H<sub>2</sub>hfipbb = 4,4ā²-(hexafluoroisopropylidene)ĀbisĀ(benzoic
acid), Htrz = 1<i>H</i>-1,2,3-triazole] was assembled by
hydrothermal synthesis. Single-crystal X-ray diffraction analysis
reveals that <b>NNU-1</b> displays a twofold interpenetrating
three-dimensional (3D) framework with a {4<sup>24</sup>Ā·6<sup>4</sup>}-<b>bcu</b> topology. Interestingly, the 3D framework
contains a two-dimensional (2D) layered structure that consists of
alternating left- and right-handed double helical chains. On the basis
of the hydrophobic āCF<sub>3</sub> groups from H<sub>2</sub>hfipbb ligand, <b>NNU-1</b> possesses excellent stability in
water. It is worth noting that <b>NNU-1</b> not only shows a
highly selective fluorescence quenching effect to Fe<sup>3+</sup> ion
in aqueous solution but also resists the interference of other metals
including Fe<sup>2+</sup> ion. Accordingly, <b>NNU-1</b> probably
functions as a potential promising fluorescence sensor for detecting
Fe<sup>3+</sup> ion with high sensitivity and selectivity