Palladium-Catalyzed Domino Heck/Aryne Carbopalladation/C–H Functionalization: Synthesis of Heterocycle-Fused 9,10-Dihydrophenanthrenes

A novel palladium-catalyzed domino Heck/aryne carbopalladation/C–H functionalization reaction using in situ generated arynes has been developed in which three new C–C bonds and a carbon quaternary center are formed. This methodology affords moderate to excellent yields of heterocycle-fused 9,10-dihydrophenanthrenes

Data_Sheet_1_A configurational analysis on career success of scientific and technological innovation talents in universities.CSV

IntroductionIncreasing the career success of scientific and technological innovation talents has become an important means of keeping and using talents in countries around the world. However, the problem has not been solved effectively.MethodsThirty-five cases were chosen in this study. The combined effects of human capital, psychological capital, micro-social capital, team social capital, and macro-social capital on the career success of scientific and technological innovation talents, as well as relevant influencing mechanisms, were discussed using qualitative comparative analysis (QCA).ResultsResults demonstrate that: (a) while a single factor cannot be the only condition for the high career success of scientific and technological innovation talents in universities, increasing macro-social capital plays a relatively universal role in a high career success rate. (b) There are three paths driving the high career success of scientific and technological innovation talents in universities. (c) There are two paths driving the non-high career success of scientific and technological innovation. Both have characteristics of absent psychological capital and micro-social capital. Moreover, the driving mechanism of high career success has an asymmetrical causal relationship.DiscussionResearch conclusions are not only conducive to expanding the research perspectives of social capital theory and career success, but also provide valuable insight into how to stimulate the career success of scientific and technological innovation talents in universities.</p

Data_Sheet_2_A configurational analysis on career success of scientific and technological innovation talents in universities.pdf

IntroductionIncreasing the career success of scientific and technological innovation talents has become an important means of keeping and using talents in countries around the world. However, the problem has not been solved effectively.MethodsThirty-five cases were chosen in this study. The combined effects of human capital, psychological capital, micro-social capital, team social capital, and macro-social capital on the career success of scientific and technological innovation talents, as well as relevant influencing mechanisms, were discussed using qualitative comparative analysis (QCA).ResultsResults demonstrate that: (a) while a single factor cannot be the only condition for the high career success of scientific and technological innovation talents in universities, increasing macro-social capital plays a relatively universal role in a high career success rate. (b) There are three paths driving the high career success of scientific and technological innovation talents in universities. (c) There are two paths driving the non-high career success of scientific and technological innovation. Both have characteristics of absent psychological capital and micro-social capital. Moreover, the driving mechanism of high career success has an asymmetrical causal relationship.DiscussionResearch conclusions are not only conducive to expanding the research perspectives of social capital theory and career success, but also provide valuable insight into how to stimulate the career success of scientific and technological innovation talents in universities.</p

Methanofullerenes, C₆₀(CH₂)_<i>n</i> (<i>n</i> = 1, 2, 3), as Building Blocks for High‑Performance Acceptors Used in Organic Solar Cells

Selective preparation of C₆₀(CH₂)_<i>n</i> (<i>n</i> = 1, 2, 3) was realized via a “Bingel-decarboxylation” route. A 54π-electron derivative of C₆₀(CH₂)₂, OQBMF, demonstrates an outstanding power conversion efficiency (PCE) of 6.43% (<i>V</i>_oc = 0.95 V, <i>J</i>_sc = 9.67 mA cm^–2, FF = 70%) in fullerene:P3HT solar cells since the small CH₂ addends lift up fullerene LUMO and increase <i>V</i>_oc significantly without decreasing mobility significantly

The Impact of Glucocorticoid Treatment on Hypocalcemia Following Thyroid Surgery: A Systematic Review and Meta-Analysis

Patients undergoing thyroidectomy often develop hypocalcemia. While there is evidence suggesting that the prophylactic administration of dexamethasone in patients undergoing thyroidectomy can reduce the risk of postoperative complications including nausea, vomiting, and pain, it remains uncertain as to whether such treatment has a similar impact on hypocalcemia risk. Here, randomized controlled trials (RCTs) focused on comparing the risk of postoperative hypocalcemia in thyroidectomy patients that either were or were not administered a single preoperative dose of dexamethasone were systematically evaluated. These RCTs were identified by searching the Medline, PubMed, Embase, and Cochrane Library for all relevant publications as of April 2023. Primary study outcomes included biochemical hypocalcemia and symptomatic hypocalcemia incidence within 24 h after thyroidectomy, while the incidence of permanent hypocalcemia was a secondary outcome in this analysis. Random-effects models were used for all comparisons in this meta-analysis. In total, 8 RCTs enrolling 1666 patients were incorporated when conducting this meta-analysis. Relative to placebo control treatment, dexamethasone administration was associated with significant reductions in the rates of postoperative symptomatic hypocalcemia (OR = 0.40; 95%CI 0.16–1.00; p = 0.050) and biochemical hypocalcemia (OR = 0.34;95%CI 0.14–0.83; p = 0.020 (p < 0.05). No differences were detected between these groups with respect to the incidence of permanent hypocalcemia, and no trials revealed any evidence of glucocorticoid-associated complications. Significant heterogeneity was detected among studies, but the exclusion of any single study did not significantly alter study outcomes. The present pooled analyses suggested that one preoperative dexamethasone dose was sufficient to reduce the odds of thyroidectomy patients developing biochemical or symptomatic hypocalcemia within 24 h after the procedure. The prophylactic administration of steroids was both safe and effective, suggesting that it warrants consideration as a component of routine clinical care. However, additional prospective work will be vital to validate the efficacy of dexamethasone as a means of preventing objective hypocalcemia in this patient population.</p

Bilayer Heterostructured PThTPTI/WS₂ Photodetectors with High Thermal Stability in Ambient Environment

Organic-based photodetectors (PDs) have great potential applications in next-generation portable, low-cost, large-area displays and optical communications. However, for practical applications, they are facing big challenges due to their instabilities in ambient environments, especially under high temperatures. Robust materials and device architectures are highly demanded to overcome the problem. In this report, we employed a donor conjugated polymer PThTPTI and realized thin-film PDs which can stably operate in ambient air under temperatures as high as 300 °C. By adding a discontinuous thin layer of WS₂ beneath the PThTPTI film, the device photosensitivity is significantly enhanced without loss of the high thermal stability. This work provides new insights in designing novel and stable organic-based devices for future optoelectronic applications

Additional file 8 of Identification of environment-insensitive genes for oil content by combination of transcriptome and genome-wide association analysis in rapeseed

Additional file 8: Table S2. The information of chromosome positions of 50 stable DEGS, GWAS of oil content and previous reported QTL intervals

Additional file 3 of Identification of environment-insensitive genes for oil content by combination of transcriptome and genome-wide association analysis in rapeseed

Additional file 3: Figure S3. The analysis of candidate genes in the significant associated QTL-A08 and QTL-A10 regions. Regional Manhattan plot surrounding the peak signals on QTL-A08 (a) and QTL-A10 (d). Green dot indicates the SNPs located in the BnAPA1-A08 (a) and BnPAS2-A10 (d) gene region which are associated with oil content. Genetic structure variations of BnAPA1-A08 (b) and BnPAS2-A10 (e). c and f Boxplots showing comparative analysis between haplotypes related to oil content phenotype. p values show the significance of pairwise comparisons

Additional file 1 of Identification of environment-insensitive genes for oil content by combination of transcriptome and genome-wide association analysis in rapeseed

Additional file 1: Figure S1. Oil content phenotype of the development period and PCA distribution for LOC and HOC inbred lines using 35 DAPs FPKM. a The seed oil content of LOC and HOC inbred lines at different environments in different growth stage, the blue and gray, red and orange lines represent LOC and HOC inbred lines, respectively. b PCA distribution for LOC and HOC inbred lines using 35 DAPs FPKM. CS, HZ and KM was signed by cycle, tangle and rhombus, respectively

Additional file 6 of Identification of environment-insensitive genes for oil content by combination of transcriptome and genome-wide association analysis in rapeseed

Additional file 6: Figure S6. Co-expression network analysis. a Whole co-expression network exhibit, hexagon nodes represent eight candidate genes, triangle nodes represent genes directly linked to the candidate gene. The blue and turquoise nodes represent blue and turquoise module genes. b Top 20 KEGG enhancement of blue and turquoise module genes