A new hexahydrobenzopyran derivative from the gorgonian-derived Fungus <i>Eutypella</i> sp

<p>A new hexahydrobenzopyran derivative cytosporin L (<b>1</b>), and another eight known compounds were isolated from the gorgonian-derived fungus <i>Eutypella</i> sp. collected from the South China Sea. The structure of <b>1</b> was elucidated by comprehensive spectroscopic data. The absolute configuration of <b>1</b> was determined by a chemical reaction and the modified Mosher’s method. The isolated secondary metabolites were evaluated for their antibacterial activities. Compound <b>1</b> showed antibacterial activity towards <i>Micrococcus lysodeikticus</i> and <i>Enterobacter aerogenes</i> with the same MIC values of 3.12 μM. Compounds <b>1</b>–<b>3</b> were evaluated for antiviral activities. Compounds <b>1</b> and <b>2</b> obviously inhibited the respiratory syncytial virus (RSV) with the IC₅₀ values of 72.01 and 30.25 μM, respectively.</p

Additional file 1 of Efficacy and safety of blonanserin versus risperidone in the treatment of schizophrenia: a systematic review and meta-analysis of randomized controlled trials

Supplementary Material 1

Di-, tri-, and tetranuclear cobalt, copper, and manganese complexes bridged by <i>μ</i>-hydroxyl groups of tetradentate Schiff base ligands: structures, magnetic properties, and antitumor activities

<div><p>[Co₂(HL^<b>1</b>)₂(H₂O)₂](NO₃) (<b>1</b>), [Cu₂(H_<b>2</b>L^<b>1</b>)(HL^<b>1</b>) (CH₃COO)]·H₂O (<b>2</b>), [Cu₄(HL^<b>1</b>)₄(C₂H₅OH)]·C₂H₅OH·H₂O (<b>3</b>), and [Mn₃(HL^<b>2</b>)₂(CH₃OH)₂(CH₃COO)₄]·2(CH₃OH)·H₂O (<b>4</b>) {<b>H</b>_<b>3</b><b>L</b>^<b>1</b><b> </b>= 2-ethyl-2-(2-hydroxybenzylideneamino)propane-1,3-diol, <b>H</b>_<b>3</b><b>L</b>^<b>2</b><b> </b>= 2-ethyl-2-[(2-hydroxynaphthalene-1-yl)methyleneamino]propane-1,3-diol} have been synthesized and characterized by IR spectra, elemental analyses, single-crystal X-ray diffraction, TGA, XRD, and magnetic measurements. Compound <b>1</b> possesses mixed-valence dinuclear {Co₂(<i>μ</i>₂-O)₂} with Co(II) and Co(III) ions linked through <i>μ</i>₂-hydroxyl of Schiff base ligands. Compound <b>2</b> displays a binuclear structure with {Cu₂(<i>μ</i>₂-O)(<i>η</i>²-COO)} containing one <i>μ</i>₂-hydroxyl and a single <i>syn–syn</i> acetate bridge. Compound <b>3</b> is tetranuclear with a cube-shaped {Cu₄(<i>μ</i>₃-O)₄} core constructed by four Cu(II) centers and four <i>μ</i>₃-hydroxyls of Schiff base ligands. Compound <b>4</b> displays a linear trinuclear {Mn₃(<i>μ</i>₂-O)₂(<i>η</i>²-COO)₂} structure in which the terminal Mn(III) and the central Mn(II) ions are linked by a <i>μ</i>₂-hydroxyl of Schiff base and two <i>syn–syn</i> acetate bridges. The results show that terminal hydroxyl groups of Schiff base ligands play an important role in assembling polynuclear compounds. Magnetic properties and antitumor activities of these compounds were investigated. The antitumor activities reveal that <b>1</b> and <b>2</b> are more effective antitumor agents for K-562 and HL-60, respectively.</p></div