Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study

Background: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. Objectives: To identify early-life risk factors for eczema, and to explore how early-life risk factors explain any differences in eczema. Methods: We estimated odds ratios (ORs) for ever having had eczema by age 5 years in 14 499 children from the U.K. Millennium Cohort Study (MCS), with a focus on maternal, antenatal and early-life risk factors and socioeconomic circumstances (SECs). Risk factors were explored to assess whether they attenuated associations between SECs and eczema. Results: Overall 35·1% of children had ever had eczema by age 5 years. Children of mothers with degree-level qualifications vs. no educational qualifications were more likely to have eczema (OR 1·52, 95% confidence interval 1·31–1·76), and there was a gradient across the socioeconomic spectrum. Maternal atopy, breastfeeding (1–6 weeks and ≥ 6 months), introduction of solids under 4 months or cow's milk under 9 months, antibiotic exposure in the first year of life and grime exposure were associated with an increased odds of having eczema. Female sex, Pakistani and Bangladeshi ethnicity, smoking during pregnancy, exposure to environmental tobacco smoke and having more siblings were associated with reduced odds for eczema. Controlling for maternal, antenatal and early-life characteristics (particularly maternal smoking during pregnancy, breastfeeding and number of siblings) reduced the OR for eczema to 1·26 (95% confidence interval 1·03–1·50) in the group with the highest educational qualifications compared with the least. Conclusions: In a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early-life factors including not smoking during pregnancy, breastfeeding and having fewer siblings

Use of cumulative mortality data in patients with acute myocardial infarction for early detection of variation in clinical practice: observational study

OBJECTIVES: Use of cumulative mortality adjusted for case mix in patients with acute myocardial infarction for early detection of variation in clinical practice. DESIGN: Observational study. SETTING: 20 hospitals across the former Yorkshire region. PARTICIPANTS: All 2153 consecutive patients with confirmed acute myocardial infarction identified during three months. MAIN OUTCOME MEASURES: Variable life­adjusted displays showing cumulative differences between observed and expected mortality of patients; expected mortality calculated from risk model based on admission characteristics of age, heart rate, and systolic blood pressure. RESULTS: The performance of two individual hospitals over three months was examined as an example. One, the smallest district hospital in the region, had a series of 30 consecutive patients but had five more deaths than predicted. The variable life­adjusted display showed minimal variation from that predicted for the first 15 patients followed by a run of unexpectedly high mortality. The second example was the main tertiary referral centre for the region, which admitted 188 consecutive patients. The display showed a period of apparently poor performance followed by substantial improvement, where the plot rose steadily from a cumulative net lives saved of - 4 to 7. These variations in patient outcome are unlikely to have been revealed during conventional audit practice. CONCLUSIONS: Variable life­adjusted display has been integrated into surgical care as a graphical display of risk­adjusted survival for individual surgeons or centres. In combination with a simple risk model, it may have a role in monitoring performance and outcome in patients with acute myocardial infarction

On Hawking's Local Rigidity Theorems for Charged Black Holes

We show the existence of a Hawking vector field in a full neighborhood of a local, regular, bifurcate, non-expanding horizon embedded in a smooth Einstein-Maxwell space-time without assuming the underlying space-time is analytic. It extends one result of Friedrich, R\'{a}cz and Wald, which was limited to the interior of the black hole region. Moreover, we also show, in the presence of an additional Killing vector field $T$ which tangent to the horizon and not vanishing on the bifurcate sphere, then space-time must be locally axially symmetric without the analyticity assumption. This axial symmetry plays a fundamental role in the classification theory of stationary black holes.Comment: 20 page

Galois theory and Lubin-Tate cochains on classifying spaces

We consider brave new cochain extensions F(BG +,R) → F(EG +,R), where R is either a Lubin-Tate spectrum E n or the related 2-periodic Morava K-theory K n , and G is a finite group. When R is an Eilenberg-Mac Lane spectrum, in some good cases such an extension is a G-Galois extension in the sense of John Rognes, but not always faithful. We prove that for E n and K n these extensions are always faithful in the K n local category. However, for a cyclic p-group C p r, the cochain extension F(BC p r +,E n ) → F(EC p r +, E n ) is not a Galois extension because it ramifies. As a consequence, it follows that the E n -theory Eilenberg-Moore spectral sequence for G and BG does not always converge to its expected target

Gaia, White Dwarfs, and the Age of the Galaxy

The Milky Way is composed of four major stellar populations: the thin disk, thick disk, bulge, and halo. At present, we do not know the age of any of these populations to better than one or two billion years. This lack of knowledge keeps us from answering fundamental questions about the Galaxy: When did the thin disk, thick disk, and halo form? Did they form over an extended period, and if so, how long? Was star formation continuous across these populations or instead occur in distinct episodes? The Gaia satellite is providing precise trigonometric parallaxes for a plethora of white dwarfs in each of these populations. We combine these parallaxes (and hence, distances) with photometry and analyze them using a modeling technique that relies on Bayesian statistics. This allows us to derive precise ages for individual white dwarfs and determine the age distribution and star formation history for each of the constituents of our Galaxy. Here we will present current progress in this endeavor, with emphasis on the ages of individual white dwarfs in the Hyades. Measuring the ages of individual white dwarfs in well-studied clusters provides proof of concept for our technique, as well exploration of any systematic offsets caused from timescales from main sequence models, as well as the initial-final mass relation

The quadratic spinor Lagrangian is equivalent to the teleparallel theory

The quadratic spinor Lagrangian is shown to be equivalent to the teleparallel / tetrad representation of Einstein's theory. An important consequence is that the energy-momentum density obtained from this quadratic spinor Lagrangian is essentially the same as the ``tensor'' proposed by Moller in 1961.Comment: 10 pages, RevTe

A black ring with a rotating 2-sphere

We present a solution of the vacuum Einstein's equations in five dimensions corresponding to a black ring with horizon topology S^1 x S^2 and rotation in the azimuthal direction of the S^2. This solution has a regular horizon up to a conical singularity, which can be placed either inside the ring or at infinity. This singularity arises due to the fact that this black ring is not balanced. In the infinite radius limit we correctly reproduce the Kerr black string, and taking another limit we recover the Myers-Perry black hole with a single angular momentum.Comment: 10 page

Distribution Control and Measurement of Irrigation Water on the Farm

An irrigation system should be designed to provide correct distribution, control, and measurement of the irrigation water. Usually a farmer takes his irrigation water from a canal through a headgate. Or he may receive it from a pipeline regulated by a valve, or perhaps from his own well and pump. Open ditches are most commonly used to carry the water to the fields. Water control structures are used to get it out of the ditches and onto the fields. Measurement devices are needed so the farmer can tell how much water he has applied to his field at any irrigation or over the season. Several types of structures are used to divert, convey, control, or measure irrigation water. Some of these are described, and their functions discussed, in this publication

Effects of land markets and land management on ecosystem function: A framework for modelling exurban land-change

This paper presents the conceptual design and application of a new land-change modelling framework that represents geographical, sociological, economic, and ecological aspects of a land system. The framework provides an overarching design that can be extended into specific model implementations to evaluate how policy, land-management preferences, and land-market dynamics affect (and are affected by) land-use and land-cover change patterns and subsequent carbon storage and flux. To demonstrate the framework, we implement a simple integration of a new agent-based model of exurban residential development and land-management decisions with the ecosystem process model BIOME-BGC. Using a stylized scenario, we evaluate the influence of different exurban residential-land-management strategies on carbon storage at the parcel level over a 48-year period from 1958 to 2005, simulating stocks of carbon in soil, litter, vegetation, and net primary productivity. Results show 1) residential parcels with management practices that only provided additions in the form of fertilizer and irrigation to turfgrass stored slightly more carbon than parcels that did not include management practices, 2) conducting no land-management strategy stored more carbon than implementing a strategy that included removals in the form of removing coarse woody debris from dense tree cover and litter from turfgrass, and 3) the removal practices modelled had a larger impact on total parcel carbon storage than our modelled additions. The degree of variation within the evaluated land-management practices was approximately 42,104 kg C storage on a 1.62 ha plot after 48 years, demonstrating the substantial effect that residential land-management practices can have on carbon storag