Koninginins R-S from the endophytic fungus <i>Trichoderma koningiopsis</i>

<p>Two new metabolites named koninginins R-S (<b>1</b>–<b>2</b>) were isolated from the culture of <i>Trichoderma koningiopsis</i> YIM PH30002. Their chemical structures were elucidated by the extensive spectroscopic analysis. These isolated compounds showed certain antifungal activities against phytopathogens, <i>Fusarium flocciferum</i> and <i>Fusarium oxysporum</i>.</p

New Duclauxamide from <i>Penicillium manginii</i> YIM PH30375 and Structure Revision of the Duclauxin Family

Duclauxamide A1 (<b>1</b>), a new polyketide-derived heptacyclic oligophenalenone dimer with a <i>N</i>-2-hydroxyethyl moiety, was isolated from <i>Penicillium manginii</i> YIM PH30375. Spectroscopic analysis, X-ray single crystal diffraction, and ¹³C NMR DFT calculations confirmed that compound <b>1</b> and other duclauxin analogues possess the unified <i>S</i> configuration at C-9′, which corrects a long-standing misrepresentation of duclauxins as C-9′<i>R</i> epimers. A plausible biosynthetic pathway for duclauxins is proposed on the basis of previous acetate labeling results for duclauxin and sclerodin

New Duclauxamide from <i>Penicillium manginii</i> YIM PH30375 and Structure Revision of the Duclauxin Family

Duclauxamide A1 (<b>1</b>), a new polyketide-derived heptacyclic oligophenalenone dimer with a <i>N</i>-2-hydroxyethyl moiety, was isolated from <i>Penicillium manginii</i> YIM PH30375. Spectroscopic analysis, X-ray single crystal diffraction, and ¹³C NMR DFT calculations confirmed that compound <b>1</b> and other duclauxin analogues possess the unified <i>S</i> configuration at C-9′, which corrects a long-standing misrepresentation of duclauxins as C-9′<i>R</i> epimers. A plausible biosynthetic pathway for duclauxins is proposed on the basis of previous acetate labeling results for duclauxin and sclerodin