645 research outputs found

    Blockchain for architects:Challenges from the sharing economy

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    Letters: Grey Areas

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    Places to play

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    Interaction design is increasingly about embedding interactive technologies in our built environment; architecture is increasingly about the use of interactive technologies to reimagine and dynamically repurpose our built environment. This forum focuses on this intersection of interaction and architecture. --- Mikael Wiberg, Editor </jats:p

    Interpretative communities as decisive agents: on pervasive digital technologies

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    Enhanced Epithelial Gene Transfer by Modulation of Tight Junctions with Sodium Caprate

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    The airway epithelium is resistant to infection by gene transfer vectors when infected from the luminal surface. One strategy for enhancing airway epithelial gene transfer is to modify paracellular permeability, thereby permitting the diffusion of vectors to the basolateral surface, where uptake receptors are expressed. We investigated the ability of a medium-chain fatty acid known to enhance drug absorption, sodium caprate (C10), to increase airway paracellular permeability in comparison with ethyleneglycol-bis-( β -aminoethyl ether)-N,N′ -tetraacetic acid (EGTA). Apical application of C10 decreased transepithelial resistance by > 90% within minutes, whereas EGTA required an hour or more to produce a similar effect. C10 increased mannitol and dextran permeability by sevenfold, as compared with a twofold increase produced by EGTA. A greater enhancement of adenoviral lacZ gene transfer was mediated by C10 (50-fold over controls) than by EGTA (10-fold over controls). This correlated with a significant enhan..
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