Prognostic value of DHEA, DHEAS, basal cortisol, stimulated, delta cortisol, and the ratios cortisol/DHEA and cortisol/DHEAS for functional outcome after 1 year.

*<p>adjusted for gender, age and charlson index.</p

Prognostic value of DHEA, DHEAS, basal cortisol, stimulated cortisol, delta cortisol, and the ratios cortisol/DHEA and cortisol/DHEAS for mortality after 1 year.

*<p>adjusted for gender, age and charlson index.</p

Kaplan Meier Survival Curves.

<p>A. Survival in relation to median cortisol level of 475 nmol/L. p = 0.0014, Hazard Ratio 0.35, 95% CI 0.19–0.67. B. Survival in relation to median stimulated cortisol level of 742 nmol/L. p = 0.015, Hazard Ratio 0.4496, 95% CI 0.24–0.86. C. Survival in relation to median dehydroepiandrosterone level of 15.5 nmol/L. p = 0.0236, Hazard Ratio 2.09, 95% CI 1.104 to 3.955. D. Survival in relation to median dehydroepiandrosterone-sulfate level of 2.4 umol/L. p = 0.1490, Hazard Ratio 1.60, 95% CI 0.85–3.80. E. Survival in relation to median cortisol/DHEA level of 27 nmol/nmol. p = 0.0002, Hazard Ratio 0.32, 95% CI 0.17–0.61. F: Survival in relation to median cortisol/DHEAS level of 203 nmol/micromol. p = 0.0004, Hazard Ratio 0.31, 95% CI 0.17–0.59.</p

Baseline characteristics.

<p>n = 231.</p

ROC of adrenal values.

<p>Dehydroepiandrosterone (DHEA): Area 0.59, Std. Error 0.05, 95% CI 0.49–0.69, p = 0.07 Dehydroepiandrosterone-sulfate (DHEAS): Area 0.60, Std. Error 0.04, 95% CI 0.51–0.69, p = 0.048. Basal cortisol: Area 0.71, Std. Error 0.05, 95% CI 0.61–0.80, p<0.0001. Stimulated cortisol: Area 0.67, Std. Error 0.05, 95% CI 0.57–0.77, p = 0.001. Cortisol/DHEA: Area 0.70, Std. Error 0.05, 95% CI 0.61–0.79, p<0.0001. Cortisol/DHEAS: Area 0.71, Std. Error 0.05, 95% CI 0.63–0.81, p<0.0001.</p

Adrenal hormones by PSI classes.

<p>Hormone levels are shown according to PSI classes; A. Cortisol (p = 0.001); B. DHEA (p = 0.537); C. DHEAS (p = 0.084); D. Cortisol/DHEA (p = 0.010); E. Cortisol/DHEAS (p<0.001); F. DHEA/DHEAS (p = 0.023). P values determined by Kruskal-Wallis test. <i>Definition of abbreviations:</i> DHEA  =  dehydroepiandrosterone; DHEAS  =  dehydroepiandrosterone-sulfate; CAP  =  community acquired pneumonia; PSI  =  pneumonia severity index; class I  =  low risk, class V  =  high risk; IQR =  interquartile range. Data represent median and IQR.</p

Kaplan Meier Survival Curves showing survival rates stratified by upper decile levels.

<p>Values are shown for A. Cortisol (p = 0.005); B. DHEA (p = 0.015); C. Cortisol/DHEAS (p = 0.08). P values determined by log rank test. <i>Definition of abbreviations:</i> DHEA  =  dehydroepiandrosterone; DHEAS  =  dehydroepiandrosterone-sulfate.</p

<b>Baseline Characteristics,n = 179.</b>

<p><b>Baseline Characteristics,n = 179.</b></p