State - Federal Relations in the Siting of Nuclear Power Plants: Towards Greater State Authority

The accident at the Three Mile Island (TMI), Pennsylvania nuclear powered electrical generating plant on March 28, 1979 has promoted a great deal of concern and interest in the future of nuclear power in the United States. Such concern is manifested by the unofficial moratorium imposed by the Nuclear Regulatory Commission (NRC) on the granting of new permits for the construction and operation of nuclear plants until the problems presented by the accident at TMI have been addressed. The NRC felt that the accident, at the very least, warranted consideration of a formal moratorium on plant licensing. Although a formal moratorium was never imposed, the NRC did not issue any new licenses until February, 1980, when the Tennessee Valley Authority\u27s Sequoyah Unit No. 1 was granted an interim operating permit

Statement of Walter A. M. Cooper, Chairman of the Committee on Federal Taxation of the American Institute of Accountants, Before the Senate Finance Committee, August 11, 1942

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Statement of Walter A. M. Cooper, Chairman of the Committee on Federal Taxation of the American Institute of Accountants, Before the Senate Finance Committee, August 21, 1941

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Mechanism-based strategies for the management of autoimmunity and immune dysregulation in primary immunodeficiencies

A broad spectrum of autoimmunity is now well described in patients with primary immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID is particularly challenging given the seemingly discordant goals of immune support and immune suppression. Our growing ability to define the molecular underpinnings of immune dysregulation has facilitated novel targeted therapeutics. This review focuses on mechanism-based treatment strategies for the most common autoimmune and inflammatory complications of PID including autoimmune cytopenias, rheumatologic disease, and gastrointestinal disease. We aim to provide guidance regarding the rational use of these agents in the complex PID patient population

Letters Re: Section 126 Problem

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Fracture rate of monolithic zirconia restorations up to 5 years: A dental laboratory survey

AbstractStatement of problemThe demand for ceramic restorations has increased over the past years because of their esthetic properties and the high cost of noble metals. However, the lack of long-term clinical studies and the difficulty of interpreting in vitro studies have placed the durability of ceramic restorations in doubt.PurposeThe purpose of this study was to determine the failure rate of monolithic zirconia restorations due to fracture up to 5 years of clinical performance.Material and methodsData were collected over 5 years from 2 commercial dental laboratories. Restorations that were returned to the laboratory for remake because of catastrophic failure (fracture) were identified and included. Restorations were categorized as anterior or posterior. Each category was further divided into complete-coverage single crowns (SCs) and multiple-unit fixed dental prostheses (FDPs). Fracture rates were compared and analyzed using a chi-square test (α=.05).ResultsA total of 39827 restoration records were reviewed and included 3731 anterior restorations (1952 SC; 1799 FDP) and 36096 posterior restorations (29808 SC; 6288 FDP). The overall fracture rate of up to 5 years for all restorations (anterior and posterior) was 1.09%. Fracture rates were 2.06% for all anterior restorations and 0.99% for all posterior restorations. Fracture rates were 0.97% for anterior SCs and 0.69% for posterior SCs, and the combined fracture rate (anterior and posterior) was 0.71%. For FDPs, 3.26% restorations fractured anteriorly and 2.42% fractured posteriorly, and the combined fracture rate (anterior and posterior) was 2.60%.ConclusionWithin the relative short-term evaluation of 5 years, restorations fabricated from monolithic zirconia material displayed relatively low fracture rates. Anterior restorations fractured at a slightly higher rate than posterior restorations, and FDPs fractured at a rate double that of SCs