69 research outputs found
Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa
The Role of Low-Energy (≤ 20 eV) Electrons in Astrochemistry
UV photon-driven condensed phase cosmic ice reactions have been the main focus in understanding the extraterrestrial synthesis of complex organic molecules. Low-energy (≤20 eV) electron-induced reactions, on the other hand, have been largely ignored. In this article, we review studies employing surface science techniques to study low-energy electron-induced condensed phase reactions relevant to astrochemistry. In particular, we show that low-energy electron irradiation of methanol ices leads to the synthesis of many of the same complex molecules formed through UV irradiation. Moreover, our results are qualitatively consistent with the hypothesis that high-energy condensed phase radiolysis is mediated by low-energy electron-induced reactions. In addition, due to the numbers of available low-energy secondary electrons resulting from the interaction of high-energy radiation with matter as well as differences between electron- and photon-induced processes, low-energy electron-induced reactions are perhaps as, or even more, effective than photon-induced reactions in initiating condensed-phase chemical reactions in the interstellar medium. Consequently, we illustrate a need for astrochemical models to include the details of electron-induced reactions in addition to those driven by UV photons. Finally, we show that low-energy electron-induced reactions may lead to the production of unique molecular species that could serve as tracer molecules for electron-induced condensed phase reactions in the interstellar medium
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
Stem-Cell Therapy Following High-Dose Chemotherapy in Advanced Retinoblastoma: A Systematic Review
The Influence of Institutional Ownership, Independent Commissioners, Independent Directors, and Philanthropy on Firm Value
This research aims to examine the effect of institutional ownership, independent commissioners, independent directors and philanthropy on firm value. The population in this study is the IDX classification industry start-up listed on the Indonesia Stock Exchange (IDX) from 2018 to 2020. The type of data used is financial reports and annual reports of 76 companies using the purposive sampling method. Furthermore, the analytical model used in this study is multiple linear regression analysis. Based on the results of the analysis obtained from this study, it is concluded that institutional ownership, independent commissioners and philanthropy have no effect on firm value, but independent directors have a positive effect on firm value</jats:p
"Nobody Seems to Know Where to Even Turn To": Barriers in Accessing and Utilising Dementia Care Services in England and The Netherlands
Background: Accessing post-diagnostic care can be difficult for people with dementia and their informal carers. Little is known, however, about the determinants of barriers to access, and how these might vary between countries. The aim of this study was to explore potential inequalities in access to formal dementia care services between England and the Netherlands, specifically from more disadvantaged areas. Methods: This was a mixed-methods study, involving semi-structured qualitative interviews and a carer questionnaire. People with dementia and informal carers were recruited by clinicians. The postal survey was co-produced with people with dementia, informal carers, and health care professionals. The survey asked carers about their own and their relatives with dementia's, social support service usage and financing; as well as how they were made aware of services and whether they required more support. Qualitative transcripts were analysed by two researchers in each country using thematic analysis. Results: A total of 103 carer questionnaires were received by post and 13 interviews were conducted with people with dementia and family carers between January 2020 and April 2020. Many services were accessed via self-funding. Thematic analysis generated five core themes: Health literacy; Having faith and lack of faith; Service suitability; Structural issues surrounding service provision; and Financing care. One major difference between both country's systems of care were the case manager and network support which people with dementia and carers benefitted from in the Netherlands, which was rarely the case in the UK. Conclusions: People with dementia and informal carers need to be supported better in accessing formal dementia care services in both the UK and the Netherlands, whilst some learning can be taken to improve access
“Nobody Seems to Know Where to Even Turn To”: Barriers in Accessing and Utilising Dementia Care Services in England and The Netherlands
Background: Accessing post-diagnostic care can be difficult for people with dementia and their informal carers. Little is known, however, about the determinants of barriers to access, and how these might vary between countries. The aim of this study was to explore potential inequalities in access to formal dementia care services between England and the Netherlands, specifically from more disadvantaged areas. Methods: This was a mixed-methods study, involving semi-structured qualitative interviews and a carer questionnaire. People with dementia and informal carers were recruited by clinicians. The postal survey was co-produced with people with dementia, informal carers, and health care professionals. The survey asked carers about their own and their relatives with dementia’s, social support service usage and financing; as well as how they were made aware of services and whether they required more support. Qualitative transcripts were analysed by two researchers in each country using thematic analysis. Results: A total of 103 carer questionnaires were received by post and 13 interviews were conducted with people with dementia and family carers between January 2020 and April 2020. Many services were accessed via self-funding. Thematic analysis generated five core themes: Health literacy; Having faith and lack of faith; Service suitability; Structural issues surrounding service provision; and Financing care. One major difference between both country’s systems of care were the case manager and network support which people with dementia and carers benefitted from in the Netherlands, which was rarely the case in the UK. Conclusions: People with dementia and informal carers need to be supported better in accessing formal dementia care services in both the UK and the Netherlands, whilst some learning can be taken to improve access.</jats:p
KONSEP TAX PLANNING PADA RUMAH MAKAN ABC
This study aims to understand the concept of tax planning at ABC Restaurant. Although taxes have an important role in financing the country\u27s development, the level of tax compliance in Indonesia is still low, especially in the Micro, Small and Medium Enterprises (MSME) sector. This study highlights the low level of tax awareness and knowledge among MSME owners and the need for more effective tax socialization. The methods used in this study include interviews and literature analysis. The results show that business owners tend to obtain tax information from informal sources such as the internet and indicate that increased socialization by the Directorate General of Taxes (DGT) can improve tax understanding and compliance in the MSME sector
The Effect of Food Product and Service Quality Towards Customer Satisfaction Towards Online Satisfaction on Grab Online Application
In line with the current advancement of information and communication technology, everything goes to the internet in any part of the world. Following the evolution of information and communication in the business world, such as purchasing and selling goods or services that are now done online (Winda Halimah, Nurdin Hidayat, & Nadya Fadillah Fidhyallah., 2021). The modern digital era has the potential to create numerous options for business success. It is also possible that culinary entrepreneurs who are now thriving in Indonesia may take advantage of this opportunity by developing online dining ordering systems in their culinary businesses. The participants in this study are active users of the Grab web application who have used the online service. Purposive sampling was utilized to identify respondents who have used the food service at least once in the previous three months. In this research we plan to describe the demographic characteristics of the participants, including age, gender, employment, and frequency of app usage. To achieve this, we intend to calculate frequencies, percentages, means, and standard deviations. These statistical measures will help provide a comprehensive understanding of the participant demographics. Frequency refers to the number of occurrences of each category within a variabl
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