Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.

<p>Abbreviations: BD, bipolar disorder; HC, healthy controls; SD, standard deviation; WASI, Wechsler Abbreviated Scale of Intelligence; IDS, Inventory of Depressive Symptoms; YMRS, Young Mania Rating Scale; PANSS P score, Positive and Negative Syndrome Scale positive subscale; GAF-S, Global Assessment of Functioning–symptom score; GAF-F, Global Assessment of Functioning–function score; BD PGRS, bipolar disorder polygenic risk score; ms, milliseconds.</p><p>BD PGRS values are reported as z-scores (with SD in brackets).</p><p>Complete behavioral data (response times and accuracy rates per condition) were available for 80/85 BD and 119/121 HC. For the remaining individuals (5 BD, 2 HC), an accuracy rate for each session (i.e. a combined rate for negative faces and shapes, and for positive faces and shapes) was available and was used to confirm that the participants paid attention to the task (accuracy rate: 97.4% and 96.0%, respectively).</p><p>^a Mean age at fMRI scanning. Age range was 18 to 63.</p><p>^b IDS score at scanning was available for 60/85 individuals (70.6%).</p><p>^c YMRS score at scanning was available for 69/85 individuals (81.2%).</p><p>^d PANSS P score at scanning was available for 38/85 individuals (44.7%).</p><p>^e Last six months</p><p>Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.</p

Bipolar disorder polygenic risk score is positively correlated with BOLD activation in the right inferior frontal gyrus in the entire sample (N = 206) including bipolar disorder cases and healthy controls for the Negative Faces > Shapes contrast.

<p>Color bar indicates z values. Coordinates are given in MNI space. Y = 18 (coronal view), Z = 12 (transversal view). Abbreviations: R, right; A, anterior.</p

Decreased brain activation in cuneus/precuneus in bipolar disorder cases (N = 85) compared to healthy controls (N = 121) for the Negative Faces > Shapes contrast.

<p>Color bar indicates z values. Coordinates are given in MNI space. X = 4 (sagittal view), Z = 22 (transversal view). Abbreviations: R, right; A, anterior.</p

Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.

<p>*Remains significant after Bonferroni correction (8 independent tests)</p><p>^#P < 0.05 with IQ and education in model</p><p>Abbrevations: Pos, Positive; Neg, Negative; HC, healthy controls; BD, bipolar disorder; PGRS, polygenic risk score; L, left; R, right. ‘+’, positively associated; ‘-’, negatively associated.</p><p>Coordinates are given in MNS space.</p><p>Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.</p