Signs and symptoms of Maroteaux-Lamy syndrome (MPS VI).

<p>Signs and symptoms of Maroteaux-Lamy syndrome (MPS VI).</p

Determinates influencing individual health progress (source: authors).

<p>Determinates influencing individual health progress (source: authors).</p

Regression graphs presenting Spearman´s correlation coefficient between Goldmann-correlated intraocular pressure (IOPg) and corneal clouding.

<p>Regression graphs presenting Spearman´s correlation coefficient between Goldmann-correlated intraocular pressure (IOPg) and corneal clouding.</p

Regression graphs presenting Spearman´s correlation coefficient between Perkins applanation tonometer (PAT) and corneal clouding.

<p>Regression graphs presenting Spearman´s correlation coefficient between Perkins applanation tonometer (PAT) and corneal clouding.</p

Clinical details regarding study patients.

<p>*Left eye of the patient no. 3 was excluded from the statistical analysis due to corneal transplantation.</p><p>Grading of corneal clouding according to Couprie et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133586#pone.0133586.ref012" target="_blank">12</a>]; BCVA–best corrected visual acuity (decimal); OD–right eye; OS–left eye.</p

Median, 25% percentile, 75% percentile and ranges of rebound tonometry (RT-IOP), Perkins applanation tonometry (PAT-IOP), corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated intraocular pressure (IOPg), corneal hysteresis (CH) and corneal resistance factor (CRF) for the right (OD) and left eyes (OS).

<p>All IOP values are presented in mmHg.</p><p>Median, 25% percentile, 75% percentile and ranges of rebound tonometry (RT-IOP), Perkins applanation tonometry (PAT-IOP), corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated intraocular pressure (IOPg), corneal hysteresis (CH) and corneal resistance factor (CRF) for the right (OD) and left eyes (OS).</p

Intraclass correlation coefficients (ICCs), 95% confidence intervals and p-values for agreement between: rebound tonometry (RT-IOP), Goldmann-correlated intraocular pressure (ORA-IOPg), corneal-compensated intraocular pressure (ORA-IOPcc) and Perkins applanation tonometry (PAT-IOP) in right (OD) and left (OS) eyes.

<p>Intraclass correlation coefficients (ICCs), 95% confidence intervals and p-values for agreement between: rebound tonometry (RT-IOP), Goldmann-correlated intraocular pressure (ORA-IOPg), corneal-compensated intraocular pressure (ORA-IOPcc) and Perkins applanation tonometry (PAT-IOP) in right (OD) and left (OS) eyes.</p

Bland-Altman plots show the agreement between rebound tonometry (RT-IOP), Goldmann-correlated intraocular pressure (ORA-IOPg), corneal-compensated intraocular pressure (ORA-IOPcc) and Perkins applanation tonometry (PAT-IOP) in right eyes.

<p>Bland-Altman plots show the agreement between rebound tonometry (RT-IOP), Goldmann-correlated intraocular pressure (ORA-IOPg), corneal-compensated intraocular pressure (ORA-IOPcc) and Perkins applanation tonometry (PAT-IOP) in right eyes.</p

Regression graphs presenting Spearman´s correlation coefficient between corneal-compensated intraocular pressure (IOPcc) and corneal clouding.

<p>Regression graphs presenting Spearman´s correlation coefficient between corneal-compensated intraocular pressure (IOPcc) and corneal clouding.</p

DMSO control infiltrations into XopL_Xe-expressing tissue did not rescue MTs.

Confocal microscopy of lower epidermal cells of GFP-TUA6 (labels MTs) stable transgenic N. benthamiana leaves. Leaves were agroinfected (OD600 of 0.4) to express (A-C) XopLXe-mCherry, (D-F) XopLm-mCherry and (K-M) mCherry which was then treated with DMSO at 4 hpi. Samples were harvested for microscopy 2 dpi. The GFP channel is visible in white (labeled MTs), the mCherry channel in magenta. Plastids are visible in cyan. Scale bars are 20 μm. (TIFF)</p