Increased amygdala activity in <i>CACNA1C</i> SNP rs1006737 risk allele carriers.

<p>Carriers of the <i>CACNA1C</i> SNP rs1006737 risk allele A have significantly increased activity in the left amygdala in the total sample (x = −24, y = −2, z = −14; FWE P = 0.026) and BD subgroup (x = −24, y = 0, z = −14; FWE P = 0.041), and non-significantly increased activity in the right amygdala in the total sample (x = 26, y = 0, z = −16) and BD subgroup (x = 22, y = 0, z = −20) compared with GG homozygotes during a negative faces paradigm. Abbreviations: BD, bipolar disorder; FWE, family-wise error. Threshold for significance in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056970#pone-0056970-g001" target="_blank">Figure 1</a> is set to Nominal P<0.05 within the ROI.</p

Results for <i>CACNA1C</i> SNP rs1006737 (AA+AG>GG) effect on amygdala activation in a sample of bipolar disorder and schizophrenia cases and healthy controls.

<p>Abbreviations: BD, bipolar disorder; SZ, schizophrenia; CTR, healthy controls; FWE, Family-wise error rate; n.s., non-significant.</p><p>Only nominally significant results (Nominal P = <0.05) are shown.</p