Chest Radiography

<p>Chest radiography shows a large mass in the RLL before gefitinib treatment (A), and marked decrease in tumor size two months after gefitinib was initiated (B). This tumor progressed nine months after gefitinib treatment (C).</p

MOESM3 of Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study

Additional file 3: Table S2. Comparison of surgery responses in patients receiving surgery before and after tyrosine kinase inhibitor usage. *The median overall survival (OS) could not be computed

High Mortality in Severe Sepsis and Septic Shock Patients with Do-Not-Resuscitate Orders in East Asia

<div><p>Background</p><p>Severe sepsis is a potentially deadly illness and always requires intensive care. Do-not-resuscitate (DNR) orders remain a debated issue in critical care and limited data exist about its impact on care of septic patients, particularly in East Asia. We sought to assess outcome of severe sepsis patients with regard to DNR status in Taiwan.</p><p>Methods</p><p>A retrospective cohort study was conducted in intensive care units (ICUs) between 2008 and 2010. All severe sepsis patients were included for analysis. Primary outcome was association between DNR orders and ICU mortality. Volume of interventions was used as proxy indicator to indicate aggressiveness of care.</p><p>Results</p><p>Sixty-seven (9.4%) of 712 patients had DNR orders on ICU admission, and these patients were older and had higher disease severity compared with patients without DNR orders. Notably, DNR patients experienced high ICU mortality (90%). Multivariate analysis revealed that the presence of DNR orders was independently associated with ICU mortality (odds ratio: 6.13; 95% confidence interval: 2.66–14.10). In propensity score-matched cohort, ICU mortality rate (91%) in the DNR group was statistically higher than that (62%) in the non-DNR group (p <0.001). Regarding ICU interventions, arterial and central venous catheterization were more commonly used in DNR patients than in non-DNR patients.</p><p>Conclusions</p><p>From the Asian perspective, septic patients placed on DNR orders on ICU admission had exceptionally high mortality. In contrast to Western reports, DNR patients received more ICU interventions, reflecting more aggressive approach to dealing with this patient population. The findings in some ways reflect differences between East and West cultures and suggest that DNR status is an important confounder in ICU studies involving severely septic patients.</p></div

Interventions and procedures during the intensive care unit (ICU) stay according to the do-not-resuscitate (DNR) status on ICU admission.

(A) Entire cohort (n = 712); (B) Matched cohort (n = 126). #, significant difference between DNR and non-DNR patients.</p

MOESM2 of Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study

Additional file 2: Table S1. Comparison of treatment responses in patients receiving radiotherapy before and after tyrosine kinase inhibitor usage

MOESM1 of Clinical factors associated with treatment outcomes in EGFR mutant non-small cell lung cancer patients with brain metastases: a case-control observational study

Additional file 1: Figure S1. Progression-free survival in patients with different epidermal growth factor receptor gene mutation types

Propensity score matching.

Distribution of propensity scores in (A) the do-not-resuscitate (DNR) and non-DNR groups and (B) the matched DNR and non-DNR groups.</p

Patient characteristics with regard to the do-not-resuscitate status.

<p>Patient characteristics with regard to the do-not-resuscitate status.</p

Characteristics of propensity score-matched cohort.

<p>Characteristics of propensity score-matched cohort.</p

Layout of BluePoint MycoID <i>plus</i> kit for identification of nontuberculous mycobacteria species, <i>M</i>. <i>tuberculosis</i> and resistance-associated mutations.

<p>B, baseline; IC, internal amplification control; M, position marker; NC, negative control; PC, positive control; WT, wild-type; MTBC, <i>M</i>. <i>tuberculosis</i> complex; TB, <i>M</i>. <i>tuberculosis</i>; bov, <i>M</i>. <i>bovis</i>; can, <i>M</i>. <i>canettii</i>; MAC, <i>M</i>. <i>avium</i> complex; abs, <i>M</i>. <i>abscessus</i> complex; avi, <i>M</i>. <i>avium</i>; che, <i>M</i>. <i>chelonae</i>; for, <i>M</i>. <i>fortuitum</i>; gas, <i>M</i>. <i>gastri</i>; gor, <i>M</i>. <i>gordonae</i>; hae, <i>M</i>. <i>haemophilum</i>; int, <i>M</i>. <i>intracellulare</i>; kan, <i>M</i>. <i>kansasii</i>; mal, <i>M</i>. <i>malmoense</i>; mar, <i>M</i>. <i>marinum</i>; non, <i>M</i>. <i>nonchromogenicum</i>; per, <i>M</i>. <i>peregrinum</i>; scr, <i>M</i>. <i>scrofulaceum</i>; sim/le3, <i>M</i>. <i>simiae/M</i>. <i>lentiflavum</i>; sme, <i>M</i>. <i>smegmatis</i> group; szu, <i>M</i>. <i>szulgai</i>; ter, <i>M</i>. <i>terrae</i>; xen, <i>M</i>. <i>xenopi</i>. (<i>M</i>. <i>avium</i> complex includes <i>M</i>. <i>avium</i> subsp. <i>avium</i>, <i>M</i>. <i>avium</i> subsp. <i>paratuberculosis</i>, <i>M</i>. <i>avium</i> subsp. <i>hominissuis</i>, <i>M</i>. <i>avium</i> subsp. <i>silvaticum</i>, <i>M</i>. <i>lepraemurium</i>, <i>M</i>. <i>intracellulare</i>, <i>M</i>. <i>marseillense</i> sp. nov., <i>M</i>. <i>timonense</i> sp. nov., <i>M</i>. <i>bouchedurhonense</i> sp. nov., and <i>M</i>. <i>yongonense</i> sp. nov. <i>M</i>. <i>abscessus</i> complex includes <i>M</i>. <i>abscessus</i>, <i>M</i>. <i>massiliense</i>, and <i>M</i>. <i>bolletii</i>. <i>M</i>. <i>smegmatis</i> group includes <i>M</i>. <i>smegmatis</i> and <i>M</i>. <i>goodie</i>.).</p