Emerging Trends of Nanotechnology towards Picotechnology: Energy and Biomolecules

In nature, metal oxide particles display their existence at the level of picomolecules in solution state and bioactive states in the body. We present evidence of picomolar behavior of molecules different than nanomolar behavior of particles. These particles can be encapsulated in polymers and can be functionalized with protein, nucleotides, and drugs to develop as smart intracellular targeting pico-devices. The preparation technique and physiological conditions decide the size and functionality of these pico-carrier devices. Their usable success rate, feasibility and potentials are yet to be proven or we do not know. The major difference between nanodevices and pico-devices is their intermolecular and intramolecular thermodynamics in medium and their molecular conformational interaction with molecular assembly in cytoarchitecture of the neurofilament, actin-myosin, microtubule proteins. Pico-carrier devices can be presumed as potential spears without interacting with host signal transduction and immunoprotection. In conclusion, the ultrafine size of newer picotechnology products may be better suited and easier to functionalize for design of particle based picodrugs, picochemicals, and pico-targeting molecules

Yukawa Corrections from Four-Point Functions in Intersecting D6-Brane Models

We discuss corrections to the Yukawa matrices of the Standard Model (SM) fermions in intersecting D-brane models due to four-point interactions. Recently, an intersecting D-brane model has been found where it is possible to obtain correct masses and mixings for all quarks as well as the tau lepton. However, the masses for the first two charged leptons come close to the right values but are not quite correct. Since the electron and muon are quite light, it is likely that there are additional corrections to their masses which cannot be neglected. With this in mind, we consider contributions to the SM fermion mass matrices from four-point interactions. In an explicit model, we show that it is indeed possible to obtain the SM fermion masses and mixings which are a better match to those resulting from experimental data extrapolated at the unification scale when these corrections are included. These corrections may have broader application to other models.Comment: 24 pages, 4 figure

How Reliable Are Reliability-Based Multiple Factor Code Formats?

Hazard

Nonequilibrium spin transport on Au(111) surfaces

The well-known experimentally observed \textit{sp}-derived Au(111) Shockley surface states with Rashba spin splitting are perfectly fit by an effective tight-binding model, considering a two-dimensional hexagonal lattice with $p_{z}$-orbital and nearest neighbor hopping only. The extracted realistic band parameters are then imported to perform the Landauer-Keldysh formalism to calculate nonequilibrium spin transport in a two-terminal setup sandwiching a Au(111) surface channel. Obtained results show strong spin density on the Au(111) surface and demonstrate (i) intrinsic spin-Hall effect, (ii) current-induced spin polarization, and (iii) Rashba spin precession, all of which have been experimentally observed in semiconductor heterostructures, but not in metallic surface states. We therefore urge experiments in the latter for these spin phenomena.Comment: 5 pages, 3 figures, to be published in Phys. Rev.

Spin and charge transport in U-shaped one-dimensional channels with spin-orbit couplings

A general form of the Hamiltonian for electrons confined to a curved one-dimensional (1D) channel with spin-orbit coupling (SOC) linear in momentum is rederived and is applied to a U-shaped channel. Discretizing the derived continuous 1D Hamiltonian to a tight-binding version, the Landauer-Keldysh formalism (LKF) for nonequilibrium transport can be applied. Spin transport through the U-channel based on the LKF is compared with previous quantum mechanical approaches. The role of a curvature-induced geometric potential which was previously neglected in the literature of the ring issue is also revisited. Transport regimes between nonadiabatic, corresponding to weak SOC or sharp turn, and adiabatic, corresponding to strong SOC or smooth turn, is discussed. Based on the LKF, interesting charge and spin transport properties are further revealed. For the charge transport, the interplay between the Rashba and the linear Dresselhaus (001) SOCs leads to an additional modulation to the local charge density in the half-ring part of the U-channel, which is shown to originate from the angle-dependent spin-orbit potential. For the spin transport, theoretically predicted eigenstates of the Rashba rings, Dresselhaus rings, and the persistent spin-helix state are numerically tested by the present quantum transport calculation.Comment: 16 pages, 7 figure

Spin precession due to spin-orbit coupling in a two-dimensional electron gas with spin injection via ideal quantum point contact

We present the analytical result of the expectation value of spin resulting from an injected spin polarized electron into a semi-infinitely extended 2DEG plane with [001] growth geometry via ideal quantum point contact. Both the Rashba and Dresselhaus spin-orbit couplings are taken into account. A pictorial interpretation of the spin precession along certain transport directions is given. The spin precession due to the Rashba term is found to be especially interesting since it behaves simply like a windshield wiper which is very different from the ordinary precession while that due to the Dresselhaus term is shown to be crystallographic-direction-dependent. Some crystallographic directions with interesting and handleable behavior of spin precession are found and may imply certain applicability in spintronic devices.Comment: 5 pages, 2 figures, submitted to Phys. Rev.

Ranking Spaces for Predicting Human Movement in an Urban Environment

A city can be topologically represented as a connectivity graph, consisting of nodes representing individual spaces and links if the corresponding spaces are intersected. It turns out in the space syntax literature that some defined topological metrics can capture human movement rates in individual spaces. In other words, the topological metrics are significantly correlated to human movement rates, and individual spaces can be ranked by the metrics for predicting human movement. However, this correlation has never been well justified. In this paper, we study the same issue by applying the weighted PageRank algorithm to the connectivity graph or space-space topology for ranking the individual spaces, and find surprisingly that (1) the PageRank scores are better correlated to human movement rates than the space syntax metrics, and (2) the underlying space-space topology demonstrates small world and scale free properties. The findings provide a novel justification as to why space syntax, or topological analysis in general, can be used to predict human movement. We further conjecture that this kind of analysis is no more than predicting a drunkard's walking on a small world and scale free network. Keywords: Space syntax, topological analysis of networks, small world, scale free, human movement, and PageRankComment: 11 pages, 5 figures, and 2 tables, English corrections from version 1 to version 2, major changes in the section of introduction from version 2 to

Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities.

Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored. Here we show that integrin-ligand interaction induces membrane blebbing and membrane permeability change. We found that sodium-proton exchanger 1 (NHE1) and sodium-calcium exchanger 1 (NCX1) are located in the membrane blebbing sites and inhibition of NHE1 disrupts membrane blebbing and decreases membrane permeability change. However, inhibition of NCX1 enhances cell blebbing to cause cell swelling which is correlated with an intracellular sodium accumulation induced by NHE17. These data suggest that sodium influx induced by NHE1 is a driving force for membrane blebbing growth, while sodium efflux induced by NCX1 in a reverse mode causes membrane blebbing retraction. Together, these data reveal a novel function of NHE1 and NCX1 in membrane permeability change and blebbing and provide the link for integrin signaling and membrane blebbing