Maximum difference wash-in slope and a delay phase slope are shown during a time course from a single voxel.

The wash-in slope (MWS, red line) and the delay phase slope (DPS, green line).</p

Differences in the MWS and DPS histogram parameters between CTZ and NTZ with different diameters of the ROI.

Differences in the MWS and DPS histogram parameters between CTZ and NTZ with different diameters of the ROI.</p

Summary of clinical and pathologic characteristics.

Summary of clinical and pathologic characteristics.</p

Differences in the MWS and DPS histogram parameters between CPZ and NPZ with different diameters of the ROI.

Differences in the MWS and DPS histogram parameters between CPZ and NPZ with different diameters of the ROI.</p

Comparison of the ROC curves of histogram parameters in the differentiation of tumors with maximum difference wash-in and delay phase slopes.

The parameters of the MWS (red lines) and those of the DPS (blue lines) in (a) the transitional zone and (b) the peripheral zone. Note the AUC of the parameters of the DPS (blue lines) are generally larger than those of the MWS (red lines) in (a), while contrary in (b).</p

The Spearman correlation coefficient for correlation of histogram parameter with Gleason score.

The Spearman correlation coefficient for correlation of histogram parameter with Gleason score.</p

Example of the selected ROI. A 57-year-old patient with elevated PSA levels and previous negative systematic TRUS biopsy.

(a) 3T mp-MRI (from left to right: T2-weighted fast spin-echo imaging, DWI, and ADC map) demonstrates an area suspected to be cancerous (stars), which was confirmed by performing targeted TRUS biopsy. (b) ROI selection was performed on the basis of corresponding DCE-MRI for CTZ (red circle) and NTZ (green circle). (c) The pathological slice at the corresponding level was correlated to confirm the representativeness of the selected ROI (circled by a marker). (d) The histogram at different diameters of the ROI of CTZ and NTZ.</p

The threshold values, AUC, sensitivity, specificity and accuracy of the histogram parameters (10 mm of ROI).

The threshold values, AUC, sensitivity, specificity and accuracy of the histogram parameters (10 mm of ROI).</p

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ‑Opioid Receptor Agonists with Anti-Inflammatory Activity <i>in Vivo</i>

In order to develop novel κ agonists restricted to the periphery, a diastereo- and enantioselective synthesis of (4a<i>R</i>,5<i>S</i>,8a<i>S</i>)-configured decahydroquinoxalines <b>5</b>–<b>8</b> was developed. Physicochemical and pharmacological properties were fine-tuned by structural modifications in the arylacetamide and amine part of the pharmacophore as well as in the amine part outside the pharmacophore. The decahydroquinoxalines <b>5</b>–<b>8</b> show single-digit nanomolar to subnanomolar κ-opioid receptor affinity, full κ agonistic activity in the [³⁵S]­GTPγS assay, and high selectivity over μ, δ, σ₁, and σ₂ receptors as well as the PCP binding site of the NMDA receptor. Several analogues were selective for the periphery. The anti-inflammatory activity of <b>5</b>–<b>8</b> after topical application was investigated in two mouse models of dermatitis. The methanesulfonamide <b>8a</b> containing the (<i>S</i>)-configured hydroxypyrrolidine ring was identified as a potent (<i>K</i>_i = 0.63 nM) and highly selective κ agonist (EC₅₀ = 1.8 nM) selective for the periphery with dose-dependent anti-inflammatory activity in acute and chronic skin inflammation