Self-Control and Adverse “Drinking” Consequences

Most research on adverse alcohol consequences such as problems with health, work, and relationships focuses only on alcohol use itself as a cause of these outcomes. However, Gottfredson and Hirschi’s (1990) self-control theory holds that alcohol use and these negative outcomes are likely to have a common cause–low self-control. Tests of hypotheses derived from self-control theory show that self-control predicts negative drinking consequences better than combined measures of alcohol dependence and frequency and quantity of drinking. This suggests that various forms of risk–taking behavior and negative outcomes can be conceptualized as indicators of underlying levels of self-control

An Ael allele-specific nucleotide insertion at the blood group ABO locus and its detection using a sequence-specific polymerase chain reaction

Genomic DNA from each of four Acl individuals (genotypes AO1, AO1var, AO2) and one AclB individual was used as a template for amplifying exons 6 and 7 of the ABO genes, which were subsequently sequenced. In all the Ael alleles a single nucleotide insertion, compared to the A consensus sequence, was observed that would alter the amino acid sequence of the glycosyltransferase immediately after its postulated nucleotide sugar binding site and furthermore extend the translated protein by 37 amino acids (16 more than the A2 enzyme). A sequence-specific primer PCR assay was developed to detect the nucleotide insertion. It was possible to differentiate all 20 serologically defined Acl/AclB individuals available from 145 blood donors with normal ABO phenotypes and genotypes and 26 individuals with various A subgroups other than A1, A2 and Acl. This mutation explains the Acl phenotype and forms the basis of a method for detecting the Ael allele

Control Theories of Crime and Delinquency: Advances in Criminological Theory, Volume 12

Book chapter, The Effect of Learning on Crime: Contrasting A General Theory of Crime and Social Learning Theory by Todd A. Armstrong. For the past twenty to thirty years, control theories of crime have been at the center of theoretical development in criminology. Key to the control theory perspective is the notion that crime is an inherently individual act, and its explanation requires that we focus on the characteristics of individuals who commit crimes. Consequently, control theory focuses on such issues as self-control and social control. The contributions to this volume explicate and extend the application of control theory. It is divided into three general areas. Part 1 focuses on key assumptions and components of control theories. Contributors discuss the notion of learning, or socialization, in the context of control theory and the effects that families, peers, and the criminal justice system have on self-control, social ties, and criminal behavior. Part 2 applies control theory to areas typically assumed to be out of the domain of self-control theory and social control theory, such as gender differences in crime, domestic violence, and group crime. Considering control theory\u27s emphasis on explaining individual criminal acts, these chapters suggest an interesting area of development by highlighting the possibility that differences in crime across or within groups may begin with individual characteristics and then making inferences about groups and group processes. Part 3 approaches the explanation of crime cross-nationally and at the macro-level. Although the authors take different approaches, they all illustrate that a theory of crime does not require culture-specific elements in order to be a valid cross-cultural explanation. Contributors to this volume include: Robert Agnew, Todd Armstrong, Leana Allen Bouffard, Augustine Brannigan, Chester Britt, Barbara Costello, Maja Dekovic, Matt DeLisi, Michael Gottfredson, Henriette Haas, Kelly H. Hardwick, Travis Hirschi, Marianne Junger, Martin Killias, Helen Mederer, Kevin Thompson, and Alexander Vazsonyi.https://digitalcommons.unomaha.edu/criminaljusticefacbooks/1001/thumbnail.jp

ABO transcript levels in peripheral blood and erythropoietic culture show different allele-related patterns independent of the CBF/NF-Y enhancer motif and multiple novel allele-specific variations in the 5'- and 3'-noncoding regions.

BACKGROUND: Mechanisms regulating the ABO gene are unclear, especially in the hematopoietic compartment. The number of 43-bp repeats in the CBF/NF-Y-binding enhancer region is considered to have a major influence on transcription. STUDY DESIGN AND METHODS: Transcript levels in peripheral blood and in erythropoietic culture of CD34+ cells from marrow donors were measured with TaqMan assays. The 5'-regulatory region and 3'-downstream sequences were investigated to determine if allelic variations occur. RESULTS: Surprisingly, transcripts from A(1) and A(2) alleles could not be detected in peripheral blood, although transcripts from B/O(1)/O(1v)/O(2) alleles were readily observed. Sequencing of approximately 4 kb upstream and 1.8 kb downstream of the coding region showed multiple novel allele-specific and allele-related motifs. No correlation between these sequence variations and transcript levels was found, however. Contradictory to the results with peripheral blood, in erythropoietic culture of CD34+ cells from healthy marrow donors transcripts from A(1) and A(2) alleles were found at higher levels than transcripts from B/O(1)/O(1v) alleles. CONCLUSION: These data do not support previous suggestions that nonsense-mutated O(1)/O(1v) transcripts are eliminated first. Furthermore, our results contradict the notion that the number of repeats in the upstream CBF/NF-Y-binding enhancer region, which contains four 43-bp repeats in A(2)/B/O(1)/O(1v) but only one 43-bp unit in A(1)/O(2) alleles, determines the transcription rate. The reason for the remarkable discrepancy between blood and marrow remains to be elucidated