Access to Densely Functionalized Chalcone Derivatives with a 2‑Pyridone Subunit via Pd/Cu-Catalyzed Oxidative Furan–Yne Cyclization of <i>N</i>‑(2-Furanylmethyl) Alkynamides under Air

A protocol for synthesis of chalcone derivatives with a 2-pyridone subunit from <i>N</i>-(2-furanylmethyl) alkynamides is reported. This synthesis involves Pd/Cu-catalyzed oxidative furan–yne cyclization at room temperature in air and may proceed via nucleopalladation of the alkyne to form a vinylpalladium intermediate, with a furan ring acting as the nucleophile