Hemiactinomycin, an undescribed intermediate of actinomycin biosynthesis from an actinomycetes strain <i>Streptomyces antibioticus</i> H41-55

Hemiactinomycin (1), an intermediate derivative of actinomycin biosynthesis, together with three known actinomycins (2-4) , were isolated from the ethanolic extract of Streptomyces antibioticus H41-55 fermentation mycelium by using various column chromatography. The structure of the derivative was established by extensive spectroscopic analysis, including HRESIMS, 1D, and 2D NMR spectroscopy. In addition, the anti-inflammatory activities of all the isolates were tested. The derivative (1) showed inhibiting NO release activities in LPS-induced RAW 264.7 macrophages with the IC50 values of 15.41 ± 0.66 μM.</p

Elevated periostin in serum and peritoneal washing fluids as potential biomarkers for endometriosis

<p><i>Background</i>: To identify the level of periostin in serum and peritoneal washing fluids (PWF) from women with and without endometriosis, as well as to explore the potential of periostin as a biomarker of endometriosis.</p> <p><i>Methods</i>: Samples were obtained from 184 women with and without endometriosis. Concentrations of periostin in PWF and blood were measured by enzyme-linked immunosorbent assay.</p> <p><i>Results</i>: Levels of periostin both in serum and PWF were notably elevated in women with endometriosis in both the proliferative and secretory phase. Combined with dysmenorrhea and infertility, two potential covariates, the serum periostin had a sensitivity of 75.00%, specificity of 65.00%, and area under the curve (AUC) of 0.774, whereas the PWF periostin had a sensitivity of 94.23%, specificity of 90.00%, and AUC of 0.967 for the diagnosis of endometriosis.</p> <p><i>Conclusion</i>: Serum and PWF periostin concentrations may be new potential biomarkers for endometriosis, especially when combined with dysmenorrhea and infertility.</p

sj-docx-1-msj-10.1177_13524585221148144 – Supplemental material for Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort

Supplemental material, sj-docx-1-msj-10.1177_13524585221148144 for Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort by Chen Hu, Blake E Dewey, Ellen M Mowry and Kathryn C Fitzgerald in Multiple Sclerosis Journal</p

Synthesis and Investigation of Chiral Poly(2,4-disubstituted-2-oxazoline)-Based Triblock Copolymers, Their Self-Assembly, and Formulation with Chiral and Achiral Drugs

Considering the largely chiral nature of biological systems, there is interest in chiral drug delivery systems. Here, we investigate for the first time polymer micelles based on poly­(2-oxazoline) (POx) ABA-type triblock copolymers with chiral and racemic hydrophobic blocks for the formulation of chiral and achiral drugs. Specifically, poly­(2-ethyl-4-ethyl-2-oxazoline) (pEtEtOx) and poly­(2-propyl-4-methyl-2-oxazoline) (pPrMeOx) were used as hydrophobic block B and poly­(2-methyl-2-oxazoline) (pMeOx) as hydrophilic block A. Using these triblock copolymers, nanoformulations of curcumin (CUR), paclitaxel (PTX), and chiral (R and S) and racemic ibuprofen were prepared. For CUR and PTX, the maximum drug loading was significantly dependent on the structure of the hydrophobic repeat units, but not the chirality. In contrast, the maximum drug loading with chiral/racemic ibuprofen was affected neither by the polymer structure nor by chirality, but minor effects were observed with respect to the size and size distribution of the drug-loaded micelles

<i>Lactobacillus acidophilus</i> attenuated TBI-mediated increase of MLCP.

<p>The interaction of <i>Lactobacillus acidophilus</i> and time on MLCP protein concentrations was not significant. (A) ELISA analysis showed that the concentrations of MLCP in intestinal smooth muscle were significantly increased after TBI, **<i>P</i> < 0.01 compared with control. <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated increase of MLCP, #<i>P</i> < 0.05 compared with TBI. (B) Immunohistochemistry analysis showed that marked increases in MLCP were observed in intestinal smooth muscle after TBI, and treatment with <i>Lactobacillus acidophilus</i> significantly attenuated TBI-mediated increases of MLCP.</p

Lewis Acid-Controlled Regioselective Phosphorylation of 2‑Indolylmethanols with Diarylphosphine Oxides: Synthesis of Highly Substituted Indoles

The Lewis acid-promoted phosphorylation of 2-indolylmethanols with diarylphosphine oxides is described. The regioselectivity of the reaction can be modulated by the choice of rare earth metal Lewis acid, offering a highly selective approach to structurally diverse indole derivatives in up to 97% yield for over 50 examples. This strategy features high selectivity, good functional group tolerance, and easy scalability. The utility of this method is further highlighted by facile modification of the products to access novel indole-based phosphine ligand

(Über-)Fachliche Unterstützung durch TREFFER

The Lewis acid-promoted phosphorylation of 2-indolylmethanols with diarylphosphine oxides is described. The regioselectivity of the reaction can be modulated by the choice of rare earth metal Lewis acid, offering a highly selective approach to structurally diverse indole derivatives in up to 97% yield for over 50 examples. This strategy features high selectivity, good functional group tolerance, and easy scalability. The utility of this method is further highlighted by facile modification of the products to access novel indole-based phosphine ligand

Rapid Self-Recoverable Hydrogels with High Toughness and Excellent Conductivity

Hydrogels as soft and wet materials have attracted much attention in sensing and flexible electronics. However, traditional hydrogels are fragile or have unsatisfactory recovery capability, which largely limit their applications. Here, a novel hydrogen bond based sulfuric acid–poly­(acrylic acid) (PAA)/poly­(vinyl alcohol) physical hydrogel is developed for addressing the above drawbacks. Sulfuric acid serves two functions: one is to inhibit the ionization of carboxyl groups from PAA chains to form more hydrogen bonds and the other is to provide conductive ions to promote conductivity of hydrogel. Consequently, the hydrogel obtains comprehensive mechanical properties, including extremely rapid self-recovery (strain = 1, instantly self-recover; strain = 20, self-recover within 10 min), high fracture strength (3.1 MPa), and high toughness (18.7 MJ m^–3). In addition, we demonstrate this hydrogel as a stretchable ionic cable and pressure sensor to exhibit stable operation after repeated loadings. This work provides a new concept to synthesize physical hydrogels, which will hopefully expand applications of hydrogel in stretchable electronics

Rapid Self-Recoverable Hydrogels with High Toughness and Excellent Conductivity

Hydrogels as soft and wet materials have attracted much attention in sensing and flexible electronics. However, traditional hydrogels are fragile or have unsatisfactory recovery capability, which largely limit their applications. Here, a novel hydrogen bond based sulfuric acid–poly­(acrylic acid) (PAA)/poly­(vinyl alcohol) physical hydrogel is developed for addressing the above drawbacks. Sulfuric acid serves two functions: one is to inhibit the ionization of carboxyl groups from PAA chains to form more hydrogen bonds and the other is to provide conductive ions to promote conductivity of hydrogel. Consequently, the hydrogel obtains comprehensive mechanical properties, including extremely rapid self-recovery (strain = 1, instantly self-recover; strain = 20, self-recover within 10 min), high fracture strength (3.1 MPa), and high toughness (18.7 MJ m^–3). In addition, we demonstrate this hydrogel as a stretchable ionic cable and pressure sensor to exhibit stable operation after repeated loadings. This work provides a new concept to synthesize physical hydrogels, which will hopefully expand applications of hydrogel in stretchable electronics