91 research outputs found

    ブンシ ヘンカン カガク ユウキ ゴウセイ カガク トクロン

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    Iridium/N-heterocyclic carbene-catalyzed C–H borylation of arenes by diisopropylaminoborane

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    Catalytic C–H borylation of arenes has been widely used in organic synthesis because it allows the introduction of a versatile boron functionality directly onto simple, unfunctionalized arenes. We report herein the use of diisopropylaminoborane as a boron source in C–H borylation of arenes. An iridium(I) complex with 1,3-dicyclohexylimidazol-2-ylidene is found to efficiently catalyze the borylation of arenes and heteroarenes. The resulting aminoborylated products can be converted to the corresponding boronic acid derivatives simply by treatment with suitable diols or diamines

    Nickel-Catalyzed Direct Alkylation of C–H Bonds in Benzamides and Acrylamides with Functionalized Alkyl Halides via Bidentate-Chelation Assistance

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    The alkylation of the ortho C–H bonds in benzamides and acrylamides containing an 8-aminoquinoline moiety as a bidentate directing group with unactivated alkyl halides using nickel complexes as catalysts is described. The reaction shows high functional group compatibility. In reactions of meta-substituted aromatic amides, the reaction proceeds in a highly selective manner at the less hindered C–H bond

    Rh(I)-catalyzed Addition of the ortho

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    Rhodium(I)-Catalyzed C8-Alkylation of 1‑Naphthylamide Derivatives with Alkenes through a Bidentate Picolinamide Chelation System

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    The rhodium­(I)-catalyzed C–H alkylation of 1-naphthylamide derivatives with alkenes at the C8-position using a picolinamide directing group is reported. Various alkenes including styrene derivatives, α,β-unsaturated carbonyl compounds, and even unactivated alkene could also be used as coupling partners. The reaction mechanism was investigated in kinetic studies, deuterium labeling studies, and control experiments. The reaction appears to proceed through a rhodium carbene intermediate, which is generated from an alkene