2,832 research outputs found
Telling stories: engaging critical literacy through urban legends in an English secondary school
Non-dominant voices have been further marginalised in the most recent National Curriculum in England (DfE 2014) and those working across the English teaching profession often find the subject framed according to narrow, assessment driven models and prescribed skill sets. This article brings together two perspectives on the importance of literacy education that remains rooted in young people's everyday experiences of place. Katie is a newly qualified secondary English teacher. She will share examples taken from her own classroom practice of the ways in which she has responded to stories told by young people about the places in which they live. Susan is a tutor of Initial Teacher Education (ITE). She suggests that Katie’s approach provides persuasive exemplification of how engagement with alternatives to a dominant view of literacy should remain a key objective for those working with beginning teachers of English. For Katie's students, urban legends are powerful texts which offer the means to explore what we do when we tell stories, both inside and outside the English classroom. As will be shown, such stories are telling examples of the resources young people can bring to critical literacy learning in current classrooms. In the context of the dominance of a narrow, mandated experience of English as a subject, the imperative becomes even greater to recognise stories such as those shared by Katie's students as opportunities for authentic, creative and critical engagement with text
Allied Health Regional Workforce Analysis: Bay Area Region
Analyzes the racial/ethnic composition of workers in twenty-two health occupations and graduates of healthcare education programs in the Bay Area. Examines disparities by race/ethnicity in the types of occupations held, educational attainment, and wages
Allied Health Regional Workforce Analysis: Central California
Analyzes the racial/ethnic compositions of workers in twenty-two health occupations and graduates of healthcare education programs in the Central Valley. Examines disparities by race/ethnicity in occupations held, educational attainment, and wages
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Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy.
PurposeRadiation dose escalation for prostate cancer improves biochemical control but is limited by toxicity. Magnetic resonance spectroscopic imaging (MRSI) can define dominant intraprostatic lesions (DIL). This phase I study evaluated dose escalation to MRSI-defined DIL using high-dose-rate (HDR) brachytherapy.Material and methodsEnrollment was closed early due to low accrual. Ten patients with prostate cancer (T2a-3b, Gleason 6-9, PSA < 20) underwent pre-treatment MRSI, and eight patients had one to three DIL identified. The eight enrolled patients received external beam radiation therapy to 45 Gy and HDR brachytherapy boost to the prostate of 19 Gy in 2 fractions. MRSI images were registered to planning CT images and DIL dose-escalated up to 150% of prescription dose while maintaining normal tissue constraints. The primary endpoint was genitourinary (GU) toxicity.ResultsThe median total DIL volume was 1.31 ml (range, 0.67-6.33 ml). Median DIL boost was 130% of prescription dose (range, 110-150%). Median urethra V120 was 0.15 ml (range, 0-0.4 ml) and median rectum V75 was 0.74 ml (range, 0.1-1.0 ml). Three patients had acute grade 2 GU toxicity, and two patients had late grade 2 GU toxicity. No patients had grade 2 or higher gastrointestinal toxicity, and no grade 3 or higher toxicities were noted. There were no biochemical failures with median follow-up of 4.9 years (range, 2-8.5 years).ConclusionsDose escalation to MRSI-defined DIL is feasible. Toxicity was low but incompletely assessed due to limited patients' enrollment
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Escape the bear and fall to the lion: the impact of avoidance availability on threat acquisition and extinction
Pervasive avoidance behaviour is a core feature of anxiety disorders. However, little is known about how the availability of avoidance modulates learned threat responding. To assess this question, we recorded avoidance behaviour, electrodermal activity and expectancy ratings in 53 healthy participants during an associative learning paradigm with embedded unavoidable and avoidable trials. When avoidance was available, we observed greater avoidance behaviour for threat versus safety cues, as well as reduced differential skin conductance responses for unavoidable threat versus safety cues. When avoidance was unavailable, as during the extinction phase, we observed sustained differential skin conductance responses for threat versus safety cues. For all phases, we found greater expectancy ratings for threat versus safe cues. Furthermore, greater avoidance behaviour predicted larger differential skin conductance responses to threat versus safety cues during extinction. Overall, the results show that the conditioned response is attenuated during situations where avoidance is available, but it recovers when avoidance is unavailable, subsequently prolonging threat extinction
A Racial Impact Analysis of HB 869/SB 274
Virginia is growing. Between 1990 and 2000, Virginia’s population rose by over 14% - the largest population growth experienced by the state in a single decade (Pollard, 2007). And the state continues to grow. It has been estimated that by 2030, Virginia’s total population may exceed 9.8 million people (Pollard, 2007). Along with population growth, land development has increased which in turn affects transportation, housing and job placement across the Commonwealth. In fact, in many parts of the state, development has outpaced population growth. According to Pollard, “If current patterns continue, Virginia will develop more land in the next 40 years than in the previous 400 years (p.8).”
In an effort to curb sprawling development and decrease transportation expenditure, the Virginia General Assembly passed House Bill 3202 in 2007. One major outcome of this multifaceted legislation was the introduction of mandatory Urban Development Areas (UDAs). The goal of UDAs was for localities to concentrate growth and development in order to reduce the cost of transportation and increase opportunities to build multi-use developments and expand affordable housing. In 2012, the General Assembly passed House Bill 869 and Senate Bill 274 which effectively make UDAs no longer mandatory but optional for all localities in the Commonwealth.
In this paper, we analyze the racial impact and explore the political history of HB 869/SB 274 while addressing the larger issue of sprawl across the Commonwealth. Smart Growth policies are known to positively impact the environment but they also positively impact low-income and minority communities by increasing access to housing, transportation and ultimately jobs. The story behind Urban Development Areas in the Commonwealth is one of politics and regulation but issues as critical as housing, transportation and job access should be focused much more on the citizens of the Commonwealth. The friction created by the UDA policy between the localities and the state has the potential to spark a statewide conversation about land use and more importantly - the need for people-centered solutions to a growing problem
The Spitzer Survey of Interstellar Clouds in the Gould Belt. VI. The Auriga-California Molecular Cloud observed with IRAC and MIPS
We present observations of the Auriga-California Molecular Cloud (AMC) at
3.6, 4.5, 5.8, 8.0, 24, 70 and 160 micron observed with the IRAC and MIPS
detectors as part of the Spitzer Gould Belt Legacy Survey. The total mapped
areas are 2.5 sq-deg with IRAC and 10.47 sq-deg with MIPS. This giant molecular
cloud is one of two in the nearby Gould Belt of star-forming regions, the other
being the Orion A Molecular Cloud (OMC). We compare source counts, colors and
magnitudes in our observed region to a subset of the SWIRE data that was
processed through our pipeline. Using color-magnitude and color-color diagrams,
we find evidence for a substantial population of 166 young stellar objects
(YSOs) in the cloud, many of which were previously unknown. Most of this
population is concentrated around the LkHalpha 101 cluster and the filament
extending from it. We present a quantitative description of the degree of
clustering and discuss the fraction of YSOs in the region with disks relative
to an estimate of the diskless YSO population. Although the AMC is similar in
mass, size and distance to the OMC, it is forming about 15 - 20 times fewer
stars.Comment: (30 pages, 17 figures (2 multipage figures), accepted for publication
in ApJ
Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families
BACKGROUND: The overwhelming majority (approximately 80%) of individuals with classic familial adenomatous polyposis (FAP) exhibit mutations in the coding sequence of the adenomatous polyposis coli (APC) tumor suppressor gene. Families without detectable APC mutations are unable to benefit from the use of genetic testing for clinical management of this autosomal dominant syndrome. METHODS: We used exome sequencing and linkage analysis, coupled with second-generation sequencing of the APC locus including non-coding regions to investigate three APC mutation-negative classical FAP families. RESULTS: We identified a novel ~11 kb deletion localized 44 kb upstream of the transcription start site of APC that encompasses the APC 1B promoter and exon. This deletion was present only in affected family members of one kindred with classical FAP. Furthermore, this same deletion with identical breakpoints was found in the probands of two additional APC mutation-negative classical FAP kindreds. Phasing analysis of single nucleotide polymorphisms (SNPs) around the deletion site in the three probands showed evidence of a shared haplotype, suggesting a common founder deletion in the three kindreds. SNP analysis within the coding sequence of APC, revealed that this ~11 kb deletion was accompanied by silencing of one of the APC alleles in blood-derived RNA of affected individuals. CONCLUSIONS: These results support the causal role of a novel promoter deletion in FAP and suggest that non-coding deletions, identifiable using second-generation sequencing methods, may account for a significant fraction of APC mutation-negative classical FAP families
Weight change and ovarian steroid profiles in young women
Objective: To investigate possible short-term effects of voluntary weight loss on ovarian steroid profiles in young women, in light of better established long-term effects in older women.
Design: We tested for an association of voluntary weight change over the course of a menstrual cycle with salivary E2 and P profiles in the same menstrual cycle.
Setting: Students were recruited in a college residence hall, and they provided daily saliva samples to a researcher living nearby.
Patient(s): The 65 women who participated were all college students and ranged in age between 18 and 23 years.
Intervention(s): None.
Main Outcome Measure(s): Weight was assessed in the first week of the menstrual cycle and first week of the following menstrual cycle. Estradiol and P were measured by radioimmunoassay in daily saliva samples.
Result(s): We did not detect a suppressive effect of weight loss on the overall level of either hormone. However, we did find evidence for more distinct follicular and luteal E2 peaks in women who gained weight. Peak luteal P also arrived about 2 days earlier in women who gained weight.
Conclusion(s): This finding adds to evidence that short-term response of ovarian function to weight loss in young women is less pronounced than long-term response in older women.AnthropologyHuman Evolutionary Biolog
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
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