Nickel-Catalyzed Cascade Reaction of 2‑Vinylanilines with <i>gem</i>-Dichloroalkenes

An efficient nickel-catalyzed cascade reaction of 2-vinylanilines with gem-dichloroalkenes has been developed to deliver diversely substituted quinolines in good to high yields. This protocol enables effective access to quinolines bearing various functional groups in the cascade process from readily available feedstock chemicals. Mechanistic studies suggest that two plausible pathways are involved in the IPr–nickel catalytic system

Synthesis of Indolo[2,1‑<i>a</i>]isoquinolines by Nickel-Catalyzed Mizoroki–Heck/Amination Cascade Reaction

An efficient Mizoroki–Heck/amination cascade reaction of o-dihaloarenes with cyclic imines was realized by combining nickel and a sterically bulky N-heterocyclic carbene ligand. This protocol provides access to a variety of indole[2,1-a]isoquinolines from readily available starting materials. This cascade approach could be applied to produce straightforward synthesis of the natural product cryptowoline

Additional file 1 of NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis

Additional file 1: Methods and supplementary figures S1 to S6