Synthesis and Characterization of Novel Four-Membered Palladacycles

Reaction of zirconophosphacyclobutenes with PdCl2(CH3CN)2 in THF yields the air- and heat-stable four-membered palladacyclic compounds in dimeric structures, which are characterized by X-ray diffraction

Synthesis and Characterization of Novel Four-Membered Palladacycles

Reaction of zirconophosphacyclobutenes with PdCl2(CH3CN)2 in THF yields the air- and heat-stable four-membered palladacyclic compounds in dimeric structures, which are characterized by X-ray diffraction

Synthesis and Characterization of Novel Four-Membered Palladacycles

Reaction of zirconophosphacyclobutenes with PdCl2(CH3CN)2 in THF yields the air- and heat-stable four-membered palladacyclic compounds in dimeric structures, which are characterized by X-ray diffraction

Copper-Promoted Tandem Reaction of Azobenzenes with Allyl Bromides via NN Bond Cleavage for the Regioselective Synthesis of Quinolines

A copper-promoted tandem reaction of a variety of azobenzenes and allyl bromides via NN bond cleavage to regioselectively construct quinoline derivatives has been developed. The azobenzenes act as not only construction units but also an oxidant for quinoline formation

Nickel-Catalyzed Arylative Carboxylation of Alkynes with Arylmagnesium Reagents and Carbon Dioxide Leading to Trisubstituted Acrylic Acids

Nickel-catalyzed arylcarboxylation of alkynes with arylmagnesium reagents and carbon dioxide (CO₂, 1 atm) was realized in one pot. Various trisubstituted acrylic acids within an aryl group at the β-position have been prepared efficiently with good regioselectivity under mild conditions. The resulting products could be further transformed to benzoannelated cycles retaining CO₂ as a one-carbon synthon

Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of <i>N</i>‑(2-Cyanoaryl)indoles

MeOTf-triggered annulation of N-(2-cyanoaryl)­indoles to provide indolo­[1,2-a]­indol-10-imines and the corresponding indolo­[1,2-a]­indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale

Reactivity of Alkynylzirconate toward α,β-Unsaturated Carbonyl Compounds

The reaction of alkynylzirconates with α,β-unsaturated carbonyl compounds has been achieved. Reactions of alkynylzirconates with cinnamates afford ester-functionalized multisubstituted dienes, in which the C3 attacks cinnamates via Michael addition. Reactions of alkynylzirconates with benzylideneacetone give (1E,3Z)-dienes, in which benzylideneacetone acts as an electrophile to afford a proton

Concise and Efficient Synthesis of Indole–Indolone Scaffolds through MeOTf-Induced Annulation of <i>N</i>‑(2-Cyanoaryl)indoles

MeOTf-triggered annulation of N-(2-cyanoaryl)­indoles to provide indolo­[1,2-a]­indol-10-imines and the corresponding indolo­[1,2-a]­indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale

CO₂‑Promoted and Nickel-Catalyzed Direct Hydroallylation of Terminal Alkynes with Allylic Alcohols: Access to 1,4-Dienes

CO2-promoted and Ni-catalyzed direct hydroallylation of terminal alkynes with allylic alcohols has been achieved. Various 1,4-dienes could be synthesized in good yield with excellent Markovnikov selectivity for alkyl- and aryl-substituted terminal alkynes under mild reaction conditions. A gram-scale reaction gives considerable yield. Preliminary mechanistic studies support the reaction pathway through sequential carboxylation/allylnickelation/lithium bicarbonate nickelation/transmetalation in the hydroallylation of alkynes with allylic alcohols in the presence of CO2